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Prevention of Amputations in Diabetics

Prevention of Amputations in Diabetics

A major risk of having diabetes is the possibility of requiring an amputation. Most frequently, amputations due to diabetes first involve the great toe with worsening gangrene, which leads to amputation of the foot, amputation of the leg below the knee, and then amputation of the leg above the knee. The following is a case study of Douglas, who was a diabetic patient who required an amputation of his lower leg beneath the knee in order to survive.

Case of a Sixty-Three-Year-Old Man with an Amputation of the Left Lower Leg from Uncontrolled Diabetes

Douglas was a sixty-three-year-old patient with a past medical history that was significant for Type 2 diabetes mellitus and high blood pressure with an inability to walk more than two blocks without shortness of breath. Because his blood sugars were continually out of control even on insulin, Douglas developed damage to the nerves in his feet (peripheral neuropathy). This led to his inability to feel an ulcer forming on the tip of his left great toe. In addition, since his diabetes led to damage to the microcirculation (smallest blood vessels) in his feet, his ability to rapidly improve  from the ulcer was significantly delayed. Within forty-five days of the first occurrence of the blister, it became infected, which led to gangrene and sepsis and admission into the intensive care unit. The gangrene kept spreading, requiring first the amputation of his left great toe, then the amputation of his left foot, and finally the amputation of his entire left leg below the left knee. This case demonstrates how the extreme and potentially deadly risk of leg amputations in diabetics can be reduced through early diagnosis of the problem and aggressive preventative care, including the use of D’OXYVA[1].

D’OXYVA is a peripheral and noninvasive deoxyhemoglobin vasodilator that dilates the microcirculation (D’OXYVA delivers pharmaceutical grade CO2 and water vapor transdermally (through the skin), dilating the smallest veins, arteries, and capillaries while increasing peripheral blood flow to the lower extremities. D’OXYVA is a pain reliever that is given for fast pain relief treatments, which are known to reduce pain and chronic conditions.

Risk Factors for Amputations in Diabetics

In a study published in the Journal of Developing Countries in 2008, it was found that, of 146 diabetic patients studied who had amputations of the foot, 74% had had diabetes for two to forty years.

In addition, forty-seven percent of the patients who were studied had ischemia (reduced blood flow), and forty-four percent had neuropathy (reduced nerve function) of the foot involved.[2]

How to Decrease the Risk of an Amputation Due to Diabetes?

Steps you can take to decrease the risk of an amputation if you are diabetic [3] include:

  • Keep your blood sugars well under control to decrease the risk of peripheral neuropathy and peripheral vascular disease.
  • Check blood sugars as directed by your physician.
  • Check your feet and toes for changes in temperature or feeling every day.
  • Examine your feet daily for cracks, blisters, cuts, redness, white areas, thick calluses, and different changes in color.
  • Stop smoking.
  • Stay on a Diabetic diet.
  • Increase daily exercise levels.
  • Continue to take all prescribed medications.

HOW D’OXYVA CAN HELP?

In an ongoing multi-year, multi-country, multi-center, randomized clinical trial on patients with diabetic foot ulcers, D’OXYVA has demonstrated speeding up diabetic wound improve and ultimately wound closure to an average of 5 weeks**.

In addition, D’OXYVA eliminated pain and improved quality of life such as sleep, appetite and mood in just a week in 100% of subjects. No adverse events of any kind were reported during, and years after the studies.

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The Many Options for Non-Invasive Treatments in Pain Management You Didn’t Know

Many patients suffer from chronic pain, with little or no relief from opioids, physical therapy or even surgical treatments. For example, Ritchie was an athletic 35-year-old man who had been diagnosed with a condition called Osgood-Schlatter’s[1] Disease at the age of 15. This condition, which is a result of rapid lower extremity bone growth in adolescents, resulted in Ritchie’s suffering with bilateral knee pain and swelling below his kneecaps. At the age of 17, Ritchie underwent arthroscopic surgery on his right knee to remove damaged cartilage. Despite this treatment, he remained in chronic pain that was unrelieved by pain medication, anti-inflammatories or physical therapy. After his physician prescribed a 7-week course of daily D’OXYVA[2] treatment, Ritchie became pain free and was able to resume all of his former sports activities, including tennis and golf.

How Common is Chronic Pain?

According to the National Center for Complementary and Integrative Health[3]chronic pain (pain lasting more than 3 months) is extremely common, affecting more than 25 million American adults every day.

In addition, at least 40 million American adults suffer from non-daily but severe chronic pain.

Patients with severe chronic pain were found to generally suffer from more chronic health problems and more disability than patients with less severe pain.

What Causes Chronic Pain?

Chronic pain can result from an injury or from a disease or condition, such as one of the following:

  • Osteoarthritis
  • Rheumatoid Arthritis
  • Fibromyalgia
  • Migraine Headaches
  • Cancer
  • Diabetic Neuropathy
  • Carpal Tunnel Syndrome
  • Post-Surgical Pain

 

Non-Invasive Treatment Options for Chronic Pain

The following have been found to be useful in the treatment of chronic pain:

  • Acupuncture
  • Massage Therapy
  • Comfrey
  • Mindfulness-based Stress Reduction
  • Progressive Relaxation
  • Spinal Manipulation
  • Yoga
  • Herbal Products, such as cayenne pepper, lavender essential oil, white willow bark and devil’s claw
  • Electromagnetic Therapy
  • Biofeedback
  • Hypnotherapy
  • Meditation
  • Tai Chi

 

The Use of D’OXYVA in the Treatment of Chronic Pain

Microcirculation refers to the blood flow in the smallest blood vessels of the body, which are the venules (smallest veins) and the capillaries (connect venules and arterioles). When the microcirculation is compromised or blocked and blood flow to the nerves is reduced, chronic pain can ensue.

D’OXYVA is a commercially available non-invasive deoxyhemoglobin vasodilator that when applied to the thumb delivers a high level of pharmaceutical grade carbon dioxide (CO2) and water vapor.

The CO2 diffuses through the skin and is delivered through the blood stream, travelling to the smallest blood vessels of the body, where it has a vasodilating effect[4] and acts as a nerve stimulant that helps relieve neurogenic pain.

Diabetic patients with uncontrolled blood sugar have reported neuropathy pain relief within minutes of administration of the D’OXYVA device.

In summary, D’OXYVA is an excellent pain reliever for many different types of chronic pain.

HOW D’OXYVA CAN HELP?

D’OXYVA® (deoxyhemoglobin vasodilator) has achieved over 90%* elimination of all sorts of chronic pain in 100% of subjects either the same day or in a few days, such as from a very high 8 to a very low 1 on the Visual Analog Scale (VAS).

Pain-free life is here. Beyond major clinical outcomes for mild to extremely severe conditions, even when strong opioid-based painkillers were ineffective, new and long-term users of D’OXYVA reported relief of persistent long-term chronic pain in 2 – 7 days associated with: Neuropathy, fibromyalgia, chemo-, and radiation therapy, chronic wounds, arthritis, osteoporosis, migraine headaches, and lower back pain.

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My Neuropathy Story: This Is How My Diabetic Neuropathy Disappeared Forever

“I was first diagnosed with diabetes at a young age,” said Bryan, 50 years old. It was in his early 20s that he started to live with devastating pain in his legs from diabetic neuropathy and had deteriorating muscular degeneration. But today, Bryan can go jogging again, and even his vision is somewhat improving.

 

What happened?

“It’s simple, I started to look at my diet, did more research and found a new solution called D’OXYVA,” said Bryan.

 

Before D’OXYVA

Bryan was diagnosed with type 1 diabetes around 30 years ago. “I couldn’t believe when my doctor told me that my blood sugar levels are high,” he said, although he admitted that other risk factors were obvious, such as being overweight and the fact that diabetes runs in his family.

He ignored his diagnosis and paid little attention to diabetes. He was told to start eating healthy, yet he continued eating what he wanted and didn’t watch his weight.

“A few years ago, I started to feel tingling in my right foot, and it got worse day after day,” said Bryan. Soon, both feet felt numb and he began to feel the pain. It was so painful that he had a hard time taking a step.

At a routine checkup, his doctor wasn’t very happy with him ignoring his diabetes. His doctor told him that his blood glucose was dangerously erratic. From that time on, he became meticulous with managing his diabetes. He started using an insulin pump and other expensive technologies that he thought could help him. But despite all his efforts, Bryan’s health continued to decline, and the pain became more devastating. Despite his eye doctor’s best efforts, Bryan’s macular degeneration was not improving.

 

A solution called D’OXYVA

Bryan decided to do some research on his own. He remembered a patient he was sitting beside in the clinic talking about a product he had had success with. The product was called D’OXYVA.

From his research, he found out that microcirculatory dysfunction renders the diabetic foot unable to mount a vasodilatory response under conditions of stress, such as injury, and makes it functionally ischemic, even in the presence of satisfactory blood flow under normal conditions. Therefore, improving microcirculation to his feet would help with pain management and avoid further nerve damage.

 

D’OXYVA is noninvasive and uses an FDA-approved pharmaceutical-grade CO2. Additionally, it is a clinically validated blood flow and nerve stimulant for people suffering from neuropathy. In various clinical trials, D’OXYVA has been validated and demonstrated above-average results in improving a host of physiological functions at the same time.

 

It’s never too late to start a new journey

“I started off with their pro health set, and strictly followed twice a day D’OXYVA therapy as advised by their therapy expert after requesting for a customized treatment plan. They were very accommodating and professional. After 6 weeks, not only did the product help ease the pain, it got rid of the numbness. Plus, it didn’t cause side effects. My eye doctor also said he sees improvement in my vision,” said Bryan.

Now, Bryan and his wife are both in continuous D’OXYVA therapy as they found out that D’OXYVA, due to its microcirculatory enhancement capability, can help her with her varicose veins.

“I can’t wait to see how I will improve more after a few more months of using D’OXYVA,” Bryan said. He feels a new sense of vitality. He is now back on his feet, living free from the pain of diabetic neuropathy, and has better control of his blood sugar than he has ever had. He and his wife are looking forward to enjoying an active retirement full of exciting adventures and activities, including spending more time with their children and grandchildren.

“I see a new life and a new hope out there for you and for everyone who is experiencing the same,” said Bryan.

HOW D’OXYVA CAN HELP?

D’OXYVA® (deoxyhemoglobin vasodilator) is a novel, clinically validated blood flow and nerve stimulant for people suffering from neuropathy. In various clinical trials, D’OXYVA has validated leading independent research results and demonstrated above-average results in improving a host of physiological functions at the same time.

Subjects suffering from high blood sugar have reported neuropathy pain relief minutes after D’OXYVA was administered and long-term blood sugar level improvements in just a few weeks.

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Did you know when used in a regimen, D`OXYVA users have reported a number of health and beauty benefits?

doxyva benefits

OPTIMIZE BLOOD CIRCULATION FOR A WIDE VARIETY OF SIGNIFICANT OUTCOMES

D’OXYVA® (deoxyhemoglobin vasodilator) in various clinical trials has validated leading independent research results and demonstrated above-average results in improving a host of physiological functions at the same time.

People using D’OXYVA® have recorded significant improvements in cardiovascular activity leading to much improved physical activity. As part of a healthy lifestyle, D’OXYVA may help significantly reduce the risk of high blood pressure, hypertension, cholesterol, and diabetes in just two or three months, with an average use of 5 minutes a day and 5 times a week.

Poor circulation is a gateway for a litany of ailments: slow healing, depression, poor complexion, sores, slow metabolism, and more.

D’OXYVA significantly improves sustained oxygen-rich microcirculatory blood flow locally and throughout the body. Its patented method of fully non-invasive, painless, and harmless transdermal delivery is unique only to D’OXYVA.

When used daily, D’OXYVA users have reported a number of health and beauty benefits, including but not limited to:

  • Relief from symptoms of microvascular complications
  • Significantly increased cardiac function, physical fitness, endurance and strength, muscle size, body tone, faster recovery from sports injuries and surgical trauma
  • Improved self-esteem via promoting healthy and radiant skin, complexion, dry skin relief, and acne reduction
  • Significant reduction in downtime from other skin treatments and cosmetic procedures when used in combination, reduction in the appearance of scars, cellulite, fat, spider veins and stretch marks
  • Promoting and maintaining a healthy weight, improving general mobility, deeper, more restful sleep
  • Significant improvement of mental acuity; concentration, problem solving, multitasking, eye-hand coordination, heightened stamina, energy, and focus while managing stress
  • Improved vitals across the board during checkups with zero adverse event reports after years of regular use by people with various health, demographic, and ethnic backgrounds

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been clinically tested to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

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Diabetic neuropathy and microcirculation

Abstract

The microcirculation in diabetic and neuropathic feet is subject to the same changes found in other end organs of diabetic patients, such as the retina or the kidney. Complications such as foot ulceration lead to further morbidity and hospitalizations. Research into the causes of microcirculatory dysfunction has revealed an interplay of numerous factors. The most prominent findings are impaired endothelium-dependent and -independent vasodilation and reduced or absent nerve-axon reflex-related vasodilation. This renders the diabetic foot unable to mount a vasodilatory response under conditions of stress, such as injury, and makes it functionally ischemic even in the presence of satisfactory blood flow under normal conditions.

Introduction

Diabetic foot problems are major contributors to health care costs and hospitalizations. Fifteen percent of diabetic patients will suffer foot ulceration, a clear risk factor for limb loss, during their lifetimes. The main causes of ulceration are diabetic neuropathy and vascular disease of both the macro- and microcirculation. A complete understanding of how the disease process works is essential in learning how to best prevent and treat these complications. Abnormalities of the microcirculation occur early in the course of diabetes [1–4]. Eventual manifestations of altered microcirculation, such as retinopathy, nephropathy, and neuropathy, are related to the duration and severity of diabetes [5,6]. In the DCCT (Diabetes Control and Complications Trial), intensive glycemic control was found to significantly delay the development and progression of these microvascular complications in type 1 diabetic patients, with similar results reported in type 2 diabetic patients [6–9]. The capillary microcirculation to foot skin undergoes changes that are similar to that of the retina, nerves, and kidneys, and has shown signs of significant impairment in diabetic patients, especially when metabolic control is poor [10].

‘Small-vessel Disease’: An Outdated Term For the purpose of clarity in discussing microcirculation, the concept of “small-vessel disease” must be eliminated. Early retrospective pathologic studies in diabetic patients who underwent amputation led to the misconception that abnormalities in the microcirculation are occlusive in nature, socalled “small-vessel disease.” It was postulated that such occlusions occur even in the absence of any macrovascular occlusive problem and cause ischemic lesions and impairment of wound healing. This idea originated from the histologic existence of periodic acid-Schiff-positive material occluding the medium-sized or small arteries in amputated limb specimens [11]. However, subsequent physiologic studies [12] and other prospective staining and arterial casting studies [13,14] have demonstrated the absence of such occlusive lesions. Furthermore, the term “small-vessel disease” initially referred to medium or small size arteries, not to the microcirculation. Therefore, as it stands, the phrase creates confusion and should no longer be used.

Read full article, here.

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been clinically tested to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

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Did you know that poor microcirculation can lead to chronic venous insufficiency?

Chronic venous insufficiency is a widespread disease of great socio-economic relevance. It is characterized by accompanying venous hypertension due to valvular dysfunction or valvular insufficiency. The high pressure in the calf veins is transmitted to small venules and skin capillaries. Characteristic symptoms are skin edema, trophic skin changes, lipodermatosclerosis, and finally venous ulcers.

These in essence microcirculation phenomena have attracted the interest of the researchers in the field of basic and clinical microcirculation. Functional and morphological changes in the microvasculature,microymphatics and the venous draining systems have been described, whose conjugated action might explain the development of chornic venous insufficiency, i.e. venous ulcers. Chronic venous insuffieciency has been particularly resistant to treatments. To counteract the high venous pressure, compression therapy has been used for many years. New develpoment includes vaso-active drugs with a preferential effect on the tone of veneous vessels and microvascular permeability. It appears that some of these drugs can restore the microvasculas and diminish leukocyte/endothelium interaction as well as micromolecular leakage.

Read whole book, here

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been clinically tested to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.