For Healthcare Professionals

What is D'OXYVA?​

D’OXYVA® (deoxyhemoglobin vasodilator) is a novel biotechnology that can be used at home and in any practice to address innumerable aspects of patient health, especially the most vulnerable cases.

Underlying many disease states are the conditions of inadequate microcirculation, impaired tissue perfusion, and autonomic nervous system imbalance D’OXYVA can address with an exceptional safety and efficacy profile at a remarkably competitive cost.

benefit D'OXYVA blood flow, circulatory, microcirculatory study for severe diabetes, cardiovascular complications

Over a decade of strong clinical evidence

In over three dozen clinical studies, D’OXYVA® has been demonstrating inducing significant and lasting improvements in peripheral blood flow, cellular oxygenation, heart rate variability, vasomotor activity and other vitals, enabling subsequent tissue healing, vascular structure regrowth (angiogenesis) and other major clinical outcomes to occur. In fact, D’OXYVA is currently undergoing expanded pivotal clinical trials as a treatment for chronic ulcers secondary to diabetes.

In previous studies, patients at risk of amputation from such ulcers saw substantial wound healing even after a few days and, complete resolution, following 4-8 weeks of continued daily D’OXYVA use.

Over 4 hours of improved blood flow with D’OXYVA delivered on the thumb in 5 minutes.

Over 97% of people record 50-300% skin perfusion pressure improvements from absolute baseline in 30-60 minutes that last for over 4 hours.

Over 37 Exceptionally Positive Studies in a Decade


How does D'OXYVA work?

D’OXYVA® delivers supersaturated CO2 + H2O Vapor™ via the skin’s sweat pores by way of a non-invasive, non-electric, non-significant risk (NSR), handheld, light-weight transdermal delivery applicator.

When a specific saturation of molecular CO2 is sensed by the circulatory and nervous systems, a cascade of cellular signaling occurs that leads to increased peripheral blood flow via vasodilation and vasoconstriction.

Tissue oxygenation is also increased via an increase in oxygen unloading in red blood cells (Bohr effect) as well as changes in cellular pathways related to oxygen delivery. With this increase in perfusion comes an increase in macro and micronutrient delivery to the tissue.


What conditions can D'OXYVA address?

D’OXYVA® can eliminate the appearance of spider veins and varicose veins and resolve associated chronic pain. It has also been found to be efficacious in addressing other common circulatory conditions, including diabetic foot ulcers and erectile dysfunction.

Athletic users of D’OXYVA have reported a significant improvement in performance as well as a decrease in the duration of recovery from injuries. Further, D’OXYVA can improve physical status and ambulation in those struggling with various musculoskeletal and neurological conditions. Users have noted enhanced mood and cognition, increased energy and appetite, and improved sleep.

D’OXYVA is appropriate for any acute or chronic state that an improvement in perfusion may benefit. Additionally, D’OXYVA can be used for any condition in which inflammation is at play, as CO2 has been observed to suppress pro-inflammatory cytokines and augment various other elements of inflammatory pathways.

Doctor says improve your circulation

Expanded pivotal trials using D’OXYVA to deliver an already FDA-approved pharmaceutical CO2 are currently underway with the involvement of eighteen of the twenty top-ranked universities in the United States. These trials are aimed at gaining FDA approval for D’OXYVA use in the treatment of severe diabetic and cardiovascular complications .


Is there clinical evidence for D'OXYVA?

An abundance of clinical evidence that reflects the efficacy of D’OXYVA® has been compiled over the past decade. D’OXYVA use has consistently been shown to increase peripheral blood perfusion by a factor of 2-3x besides significant autonomic nervous system, vasomotor, MDA, vascular structure, cellular and tissue oxygen improvements, and a host of other critical mechanisms of actions.

In over three dozen studies conducted at various academic institutions worldwide, nearly every subject has reported experiencing chronic pain relief following 1-2 weeks of D’OXYVA use. Additionally, study participants have consistently shown a decrease in systolic and diastolic arterial pressures.

Expanded pivotal trials using D’OXYVA to deliver an already FDA-approved pharmaceutical CO2 are currently underway with the involvement of eighteen of the twenty top-ranked universities in the United States. These trials are aimed at gaining FDA approval for D’OXYVA use in the treatment of severe diabetic and cardiovascular complications .


Is D'OXYVA easy to use?

D’OXYVA® use is incredibly straightforward. It can be used in virtually any setting and requires no electricity or batteries. Use requires only the applicator device and less than one fluid ounce of drinking water, which is applied to the inside of the applicator’s liquid capsule. Application typically occurs at the site of the thumb, but D’OXYVA has also shown improved efficacy when delivered elsewhere on the body, near the affected area.

Each D’OXYVA application can be accomplished in five minutes, and users can expect to see substantial measurable results within thirty to sixty minutes that can last for hours afterwards. D’OXYVA is generally intended to be used 1-4 times per day, with the frequency varying depending on individual need and severity of condition.

Is D'OXYVA safe?

D’OXYVA is recognized for its exceptional safety profile. Not a single adverse event has ever been reported over the past decade of research and use.

Family measuring D'Oxyva perfusion index (peripheral blood circulation), oxygen saturation, heart rate, repsiratory rate results with oximeter

How do patients know D'OXYVA is working?

Family measuring D'Oxyva perfusion index (peripheral blood circulation), oxygen saturation, heart rate, repsiratory rate results with oximeter

Results from the use of D'OXYVA can be demonstrated in real-time using a finger pulse oximeter that is capable of measuring the ratio of pulsatile blood flow to non-pulsatile blood flow, otherwise known as “perfusion index” (PI).

D'OXYVA users are encouraged to obtain PI values a few minutes before and 30, 60 and 90 minutes after application, with peak values usually occurring at 60 minutes.

*Free Special Finger Tip Pulse Oximeter that can measure Perfusion Index (PI) for a limited time when you purchase any D'OXYVA product set


How can I learn more?

More information about D’OXYVA® is available upon request, including details about past and ongoing clinical research and trials as well as relevant publications.

Email us directly via the below button and receive the fastest response or visit our contact page to reach out to us via other means and learn about partnering/collaborating with us. Our marketing platform can add significant value to your practice.

Frequently Asked Questions

● 2x daily for the first 2 weeks, then 1x daily for 3-5 weeks for best long-term results with spider/varicose veins and long-term cardiovascular and diabetic complications.

● 1x half hour before your workouts to feel the boost even for hours.

● 2x daily to eliminate chronic pain in 7-10 days.

Measure your blood flow (perfusion index) results with the right fingertip oximeter and adjust regimen accordingly.
D’OXYVA delivers consistent and powerful results based on Nobel Prize-winning scientific advances and groundbreaking evidence being collected at eighteen of the top twenty ranked U.S. universities by world-class medical scientists and doctors. In short, Circularity's state-of-the-art global clinical program involving over two dozen exceptionally positive high-profile pilot and pivotal studies including randomized, placebo-controlled, double-blind studies has been yielding a decade-long record of zero adverse event reports and hundreds of thousands of radically successful applications in over three dozen countries. Stay tuned for major peer-reviewed publications in prestigious journals.
The D’OXYVA® applicator device is a simple, commercially-available device to deliver transdermal carbon dioxide (CO2). It consists of a patented and patent-pending ergonomic polymer shell that is propelled by a patented single-use mini steel pressurized cartridge (45 psi) filled with pharmaceutical-grade (99.5%) liquid, purified CO2. The mini-steel cylinder is cGMP-compliant, and recyclable. D’OXYVA was identified by the Western Institutional Review Board (WIRB) in successful human clinical studies as a non-significant risk (NSR) device.

The D’OXYVA applicator device is manufactured in the United States and other countries. D’OXYVA is an ISO-complaint device, which means that Circularity Healthcare, LLC has received a certification to certify that D’OXYVA fulfills all of the domestic and international requirements for medical device regulations, like risk assessment and maintaining effective processes for safe design, manufacture and distribution.
Simply by reducing the need to spend on expensive modalities that just don’t work at the underlying problem, they only act as an expensive bandaid. However, with the help of D’OXYVA your body gets to the bottom of the problem and starts regulating critical functions to restore order and even generate new and highly beneficial resources such as vessel structure growth, tissue repair, cell production and other hormonal and neural functions. Take D’OXYVA together with your beloved supplements, vitamins and even necessary medications and treatments to boost their efficacy and likely reduce any negative effects you may be experiencing from some of them.
No, it is an ultra-portable solution that is safe for general use. You can use without any special assistance or electricity. D’OXYVA‘s over-the-skin route of administration at home or on the go has demonstrated a much safer and more effective alternative route to inhalation — a routine delivery method in hospitals.
D'OXYVA is highly effective against varicose/spider veins, diabetic ulcers, diabetic neuropathies and other circulatory issues. You may consult with your doctor about the numerous different major benefits you may be experiencing when taking D'OXYVA on a daily or weekly basis.
A medical version of D'OXYVA manufactured under ISO13485 manufacturing standards in FDA-audited facilities in the United States delivering pharmaceutical-grade molecules is FDA approved for oxygen therapy and anesthesia, and is made available through licensed physicians under prescription. The version being sold on is considered a wellness device and application without medical claims for circulatory and neurological health complications along with major quality of life benefits.
Correct. That’s why D’OXYVA’s gentle process demonstrated that it does NOT significantly increase the CO2 content in the blood or tissue and instead reduces the CO2 content per partial pressure of oxygen. This just means D’OXYVA oxygenates the blood and tissue due to inducing the beneficial Bohr effect. In addition, CO2 is a so-called gasotransmitter that signals the autonomic nervous system in the brain to launch protective mechanisms that tend to move a host of critical functions into balance (homeostasis).
Search the terms we use on this site and on the internet to learn more and measure your own results at home or with your doctor with the right pulse oximeter, for one example. Then watch your Perfusion Index (peripheral blood flow) rise quickly in just 30-60 minutes that stays elevated for several hours after a single 5-minute application (cartridge) on a thumb of your hand. Blood oxygen (SpO2) levels will improve slower, but they stay elevated for longer periods, even for 24 hours after a single application. You can measure your and your family members' results with your blood pressure and blood glucose meter as well. For example, take it before your workout to boost performance and after for rapid recovery. Take it to restore healthy blood flow for your foot wounds or back pain or headaches. Reduce the risks of major infections, chronic illnesses and skin damage.
Pronounce D'OXYVA either as DEE-OCS-EEVA or DOCS-EEVA
1. Press the lever button in the middle of the applicator with a finger then push the stop Sliding Door forward with another finger to reveal the transparent Liquid Capsule situated underneath the Sliding Door.

2. Remove the Liquid Capsule and untwist its top cap counterclockwise. Fill it with clean drinking water up to the orange marker at the bottom, twist the cap back on and place the Liquid Capsule back into the applicator with its bottom sliding ridges aligned with the ridges inside the applicator. Make sure the cap of the Liquid Capsule is facing toward the inside middle of the applicator and not toward the open end of the applicator.

3. Slide back the top sliding door until it clicks and engages with the lever button.

4. Place a cartridge inside the Cartridge Cup with its cartridge neck facing the applicator's threaded ending. Slowly turn it until it hits the end of the thread, then with a rapid, but gentle clockwise twist lock it onto the applicator.

5. Hold the applicator in your lap or any other comfortable position with a slight angle pointing the open ending, where you insert a thumb upward in a slight angle of 20-60 degrees. Push the button down in the middle of the applicator and enjoy the nearly imperceptible and pain-free delivery on a thumb or any affected body part.


Wait a few minutes after finishing the full 5-minute delivery before you remove the empty cartridge by unscrewing the Cartridge Cup counterclockwise. This allows easy retrieval and disposal of the single-use cartridges that become cold at the end of each operation. You may dispose them in any recycling bin as they are harmless to the environment.

If some water is dripping during operation that you do not like, either fill a bit less water in the Liquid Capsule or hold the applicator in a lower angle, close to 20-30 degrees.

Use the folding leg at the open ending of the applicator as an indicator for the optimal operating angle when placed on a tabletop.

Seal the open ending of the applicator during operation as much as possible by bending your thumb over it or holding it against the skin without pressing it too hard to avoid any potential mark or bruising.
Healthy skin, hair, and fur growth depends on a proper balance of delivery, waste removal, and oxygenation. D'OXYVA delivers outsized benefits by improving skin microcirculation and oxygenated blood supply delivery. By improving the animal blood flow through the microcirculation, D'OXYVA promotes healthier hair follicle growth and the body’s ability to heal underlying health conditions that diminish the animal’s fur shine. Also, it has the potential to accelerate the skin healing process after surgery and prevent wound dehiscence. Equine (horse) studies have shown that D’OXYVA has managed to deliver CO2 through their skin, and researchers have been able to identify CO2’s natural healing capabilities in the horses’ bodies via 300% blood flow improvements from baseline with a single 5-minute application.
CO2 is the protagonist in D’OXYVA’s revolutionary approach to improving healthcare and patients’ quality of life. D'OXYVA causes controlled ischemia-like stress in a local area of the body to promote central system activity and circulate humoral agents that favor micro-circulation, especially at the organ capillary beds. Adequate blood flow in the capillary bed is essential for tissue survival and optimal organ function. If blood passes too fast or does not pass at all, the tissue cannot extract O2 efficiently and will generate what is known as capillary dysfunction, which is related to chronic pain, poor wound healing, diabetic neuropathy and Alzheimer’s disease, among other conditions.
To be efficient, our body regulates organ blood flow according to its metabolic needs. As we age and develop health conditions such as diabetes, high blood pressure, digestive disorders, pain, stress, and grief, our circulatory network loses its ability to deliver adequate blood flow where it's needed the most. When this occurs, our bodies fail to heal properly, and disease follows, such as pain, acidosis, diabetes, infections, and poisoning, among other conditions.

There is still debate regarding the exact mechanism that governs the process, but there is no discussion regarding the body’s chemicals and protein protagonists that mediate and link vascular blood flow(vasodilatation) to cellular metabolisms, such as nucleotides (DNA building blocks), nitric oxide, pH, and CO2.

The vascular system reacts to metabolism by-product concentration by deciding where to allocate resources and remove waste. Standard organ functions, cell functions, and metabolism rely on our circulatory system for a constant delivery of oxygen, nutrients, hormones, electrolytes, and water and for metabolic byproduct (waste) removal.
The microcirculatory system helps our bodies to have uninterrupted blood flow where it’s needed the most. The microcirculation resides within our organs (liver, kidney, pancreas, brain, skin, etc.) and is responsible for the regional blood flow to each organ.

Our heart is a two-sided pump connected to a complex vascular system (blood vessels) arranged in series and parallel circuits, similar to a home plumbing network. Our bodies have different size arteries in charge of delivering clean, O2 saturated, and nutritive blood to our organs and veins, which are themselves in charge of carrying used blood with poor nutrients and low O2 levels from the organs. Our vascular system works in a way so that the great arteries have little impact on blood pressure, but small ones control almost 70% of the blood flow resistance (blood pressure). For example, a person can have a 50% occlusion of a large artery and be totally asymptomatic.

Each capillary bed is in charge of exchanging small molecules between organ cells and the blood and maintaining a healthy cell microenvironment (homeostasis) within the body. Each capillary bed unit is composed of:

● arteriole (blood from the heart), which is responsible for delivering nutrients and oxygen

● meta-arterial (potential capillary blood bypass route), which shunts blood to other capillary beds

● precapillary sphincter (controls blood flow), which helps to close and open the arteriole’s diameter as a response to chemical and physical stimuli

● venules (blood return to the heart), which is responsible for carrying metabolic waste and poorly oxygenated blood from the organ
Our produce and exhale CO2, and it is capable of absorbing it through the skin. The skin can absorb CO2 hundred times more efficiently than water. Once CO2 enters our system, the following changes occur:

● Dilatation of capillary arteriole sphincter (decreased capillary resistance)

● Increased blood flow through the microcirculation (organs)

● Adaptive modifications in the circulatory and autonomic nervous system that promote improved blood flow

When all these powerful adjustments occur inside the body at the same time, the positive impact of D’OXYVA's novel route of delivery of super-concentrated CO2 vapor via the skin is realized.
Judy M. Delp, Ph.D. in physiology and professor at the Florida State University, described D’OXYVA® as a simple commercially available device used to deliver transdermal CO2 that has shown remote vasodilation, which may be mediated through the release of a circulating humoral agent. CO2 improves general healthcare in several ways:

● It has natural anti-inflammatory characteristics.

● It increases blood flow through microcirculation, by arteriolar/venous dilatation.

● It produces a rightward shift in the O2 dissociation curve.

● It enhances oxygen delivery at the cellular level in the muscles, organs, brain, skin and other parts of the body.

● It is a fat-dissolving compound.

● It naturally sedates and calms the central nervous system.

● It can be used to reconstruct functionally closed capillaries.

● It can improve venous response.
The SENTEC digital monitor system has confirmed successful and constant CO2 transdermal delivery to the skin capillary bed after a 5-minute period of exposure to highly concentrated CO2 vapor produced by D’OXYVA. The perceived healthcare benefits occur almost instantly, with local microcirculation improvements followed by an increment of SPO2 that last up to 240 minutes. Nonetheless, adherence to a D’OXYVA regiment has demonstrated benefits to individuals suffering from difficult-to-heal skin wounds like diabetic ulcers, who demonstrated significant clinical improvements after two weeks of 2x daily D’OXYVA. Patients who achieved D’OXYVA adherence for over a month have shown wellness that persists in clinical trials.
Transdermal (over-the-skin) delivery of CO2 has proved to improve local microcirculation (capillary beds) blood flow and tissue perfusion, but it also positively improves systemic blood pressure and TcpO2 (most likely due to the Bohr effect). As mentioned before, therapeutic medical-grade CO2 is used for vasodilatation in the medical field for several conditions and procedures.

Locally, CO2 delivery with D'OXYVA has shown great success rates to improve the healthcare of people through:

● Treatment for varicose veins and diabetic foot

● Increased microcirculation blood flow and dissociated O2 in healthy and diabetic individuals

● Treatment for arterial stenosis obliterans

● Chronic wound healing

● Adipose tissue treatment

Systemically, CO2 delivery with D'OXYVA has shown great success to significantly:

● Reduce the risks of healthcare complications of patients with high blood pressure

● Improve general vital organ function, like that of the:

- Pancreas - Liver - Brain - Kidneys
● It is a key player in regulating extracellular hydrogen concentrations and pH through various systems, like the respiratory system, kidneys and various buffers.

● Biochemistry: An increase or decrease in 1 mmHg pCO2 will cause a decrease or increase in pH of 0.08 units in acute patients. In chronic patients, a pCO2 change of 1 mmHg will cause a pH change of 0.03 units.

● The Bohr and Haldane effects determine the interaction of O2 and CO2. At the cellular level, pCO2 concentration causes Hb-O2 dissociation.

● It is attained by our body through inhalation.

What do we usually forget about pCO2?

● Increased pCO2 promotes arteriolar dilatation in various tissues, while a modest effect has been shown in skeletal muscle tissues.

● CO2 can be delivered into our body through the skin (transdermal).

It is used in the medical industry to:

● Rapidly increase depth of anesthesia when volatile agents are being administered it increases the depth of respiration and helps to overcome breath holding and bronchial spasm

● Facilitate blind intubation in anesthetic practice

● Facilitate vasodilation and thus lessen the degree of metabolic acidosisduring the induction of hypothermia

● Increase cerebral blood flow in arteriosclerotic patients undergoing surgery

● Stimulate respiration after a period of apnea

● Prevent hypocapnia during hyperventilation

It is also used in:

● Clinical and physiological investigations

● Gynecological investigations for insufflation into the fallopian tubes and abdominal cavities

● Tissue-freezing techniques (as dry ice) and to destroy warts by freezing

What Our Customers Say

Read More
"I could not believe how my big, bulging spider veins on my leg had faded in a couple of weeks then nearly disappeared in about a couple of months. No more pain either! Thank you, D'OXYVA!"
Read More
"This gadget is amazing! It really helped reduce my back pain and my Covid-19 symptoms in a few days. Absolutely love it!"
Read More
"Love my D'OXYVA. Everyone needs this to stay fit and healthy and above all, stay in shape with a healthy weight. It only takes a few minutes a day. Must try!"