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Defects in Microcirculation and the Effect on Wound Healing: New Non-Invasive Treatments

The effects of defects in and poor functioning of the microcirculation on wound healing, especially in diabetic patients, can be devastating and life changing. As one particular example, Joseph L was a 63-year-old White male with a 24-year history of diabetes mellitus, hypertension, elevated cholesterol and arthritis. Joseph had been taking insulin for the past 12 years but his blood sugar levels were still poorly controlled.

On physical exam, Joseph had several very large, oozing and foul smelling deep ulcers located on the dorsum (top) of the left foot. After 8 weeks of intensive therapy utilizing the non-invasive D’OXYVA transdermal deoxyhemoglobin vasodilator, Joseph’s ulcers healed entirely and he avoided amputation of his left foot. Read on to learn more about this new non-invasive wound treatment that helps in wound healing.

 

What is the microcirculation?

The microcirculation refers to the smallest blood vessels in the body that supply oxygen to the tissues and remove waste products. This includes the arterioles, the venules and the capillaries. When the vessels of the microcirculation become damaged, it leads to decreased blood flow with lower oxygen blood levels and resultant damage to the skin resulting in a wound or ulcer.

Risk Factors for the Creation of Chronic Wounds

Patients with the following risk factors are at greater risk for non-healing wounds or ulcers (ulcers are the most common type of chronic wounds):

  • A history of decreased blood flow to a specific area (ischemia)
  • A history of uncontrolled diabetes (which leads to poor circulation, nerve damage and breakage of the skin)
  • A history of uncontrolled hypertension (high blood pressure)
  • A history of high cholesterol and atherosclerosis (cholesterol plaques in the arteries)
  • A history of blood clots (thrombosis)

 

Diabetic Foot Ulcers

Diabetic foot ulcers are a common complication of uncontrolled diabetes mellitus.1 Chronically elevated blood sugar levels damage the microcirculation of the lower extremities, which leads to ischemia and neuropathy (damage to the nerves). Diabetic patients often lose feeling in the feet and so are not aware of friction and pressure, which leads to breaks in the skin. This subsequently leads to open wounds that often do not heal over a 30 day period. These wounds can then become infected, leading to gangrene and eventual amputation.

 

An Example of a New Non-Invasive Treatment to Enhance Wound Healing

D’OXYVA is a non-invasive transdermal deoxyhemoglobin vasodilator that delivers FDA-approved ultra-purified CO2 molecules which diffuse through the skin leading to increased skin perfusion. In studies of the treatment of diabetic foot ulcers with D’OXYVA, increased diabetic wound healing was observed with wound closure often observed within 5 weeks.

 

Conclusion

Chronic conditions like uncontrolled diabetes and hypertension can cause damage to the microcirculation, which leads to delayed wound healing. New treatment methods like D’OXYVA deliver transdermal CO2-enhanced oxygen and nutrients to wound areas through the microcirculation. This speeds up wound healing and wound closure and helps avoid devastating complications such as amputations.

HOW D’OXYVA CAN HELP?

In an ongoing multi-year, multi-country, multi-center, randomized clinical trial on patients with diabetic foot ulcers, D’OXYVA has demonstrated speeding up diabetic wound healing and ultimately wound closure to an average of 5 weeks**.

In addition, D’OXYVA eliminated pain and improved quality of life such as sleep, appetite and mood in just a week in 100% of subjects. No adverse events of any kind were reported during, and years after the studies.

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A Success Story: Enjoying the stage again after years of chronic pain

chronic pain success story

Rachel shares how her healthcare professionals, along with the use of D’OXYVA, have helped her every step of the way.

My story started 2 years ago when I severely injured my ankle. At that time, I was working hard preparing for a dance presentation. I am a professional ballet dancer; my injury happened after a grand jeté, when I landed badly on my right foot. I needed to undergo surgery and rehab.

It was so painful that I had a hard time sleeping. Luckily, I got some pain meds so I could fall asleep. The nights were rough. I would wake up every two hours to call the nurses and ask for more medicine.

According to the doctors, this fracture could leave me limping for life. When I heard those words, my world just fell apart. I didn’t know how to accept my situation. I wouldn’t be able to dance again? I wouldn’t be able to walk again? I started to view life differently; I was hopeless.

I had to undergo months of rehab and physical therapy. Luckily, I had my friends and family to support me all the way. I slowly noticed I was feeling better; I could slowly stand up and take a few steps.

A few weeks before Christmas, due to my eagerness to recover so I could dance again, I once again aggravated my ankle after forcing it. The pain was excruciating; it felt like the first time I fractured it. That time I thought, “I’m done. I’m giving up; I will never really be able to dance again.” I had to undergo surgery and rehab for the second time, but this time, I didn’t feel like doing it; I thought it was useless, much more so after the doctor told me that the chances I could dance again were small.

One month later, I met Janina, my co-ballet dancer, at the rehab center undergoing the same physical therapy as I was. She told me she had just fractured her ankle about 4 weeks earlier; I was amazed at how fast she seemed to be recovering. I couldn’t help but ask what she had been doing or what medications she had been taking.

She then pulled a device from her bag and said, “This is D’OXYVA. This helped me with my recovery really well.” I was intrigued. Janina told me that her mother, who is diabetic, had been using D’OXYVA to manage her neuropathy and her diabetic wound, so she thought it might help her, too. Indeed, it helped her recover quickly, and she barely felt any pain from her injured ankle.

When I arrived home, I turned on my computer and did my research on D’OXYVA. Their customer support was very helpful with all the questions I had.

After almost 4 weeks of twice daily D’OXYVA therapy with the help of my orthopedic doctor and therapist, I was walking; after 5 weeks, the pain was almost gone. Now, it’s been almost 8 weeks, my D’OXYVA therapy has been reduced to 4 times a week, and I’m back at the rehearsal studio. It was an unexpected turn of events. I went from hopeless to hopeful!

I am still continuing my D’OXYVA therapy at least 3 times a week and working my way to becoming fully recovered. I’d like to thank Janina for introducing me to D’OXYVA. It gave me hope and positive vibes during my recovery stage. As for the D’OXYVA support staff, my orthopedic doctor, and my physical therapist, I couldn’t ask for a more professional, caring, and extremely helpful group. They are just plain AMAZING, all of them!

HOW D’OXYVA CAN HELP?

D’OXYVA improves blood oxygenation. Oxygen is one of the body’s natural healers. If you have ever taken deep breaths to help reduce your stress or pain, you know that increasing oxygen flow throughout your body can help with healing and minimizing pain.

In various clinical studies, D’OXYVA® (deoxyhemoglobin vasodilator) has achieved over 90%* elimination of all sorts of chronic pain in 100% of subjects either the same day or in a few days, such as from a very high 8 to a very low 1 on the Visual Analog Scale (VAS).