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The microcirculation is importantly involved in a variety of pathological conditions

The microcirculation is importantly involved in a variety of pathological conditions

Only recently, technology has been sufficient to assess microcirculatory function in intact humans. As a result, it is becoming apparent that the microcirculation is importantly involved in a variety of pathological conditions, and that microvascular dysfunction may herald, either as a marker or as a mechanism, the development of cardiovascular disease (CVD).

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This review will discuss the growing recognition that the microcirculation contributes to the development of atherosclerotic CVD, review regulation of the coronary microcirculation in humans, and discuss potential novel functions of the microcirculation, beyond regulating perfusion that might explain the intimate link to CVD.

Growing recognition that microcirculatory abnormalities contribute to cardiac prognosis supports the need for a more direct and focused understanding of how microvascular function is regulated in humans.

A number of conditions are closely associated with microvascular dysfunction. Diabetes mellitus manifests multiorgan pathology resulting from microvascular dysfunction. Nahser et al17 showed lower CFR and reduced metabolic dilation in diabetes mellitus, signs of impaired microvascular function. Di Carli et al18 expanded this observation by showing normal baseline flow but similarly reduced endothelium-dependent and endothelium-independent (dilation to adenosine) microvascular dilator capacity in young subjects with either type I or type II diabetes mellitus. Reduced dilation to adenosine persisted after controlling for duration of diabetes mellitus, insulin treatment, and autonomic neuropathy.18

Read the full paper:

https://www.ahajournals.org/doi/full/10.1161/circresaha.115.305364

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Why Use D'OXYVA?

Experts say D’OXYVA® can help patients find relief. Preliminary medical data shows people with preexisting conditions, including diabetes may experience serious complications with COVID-19.

D’OXYVA significantly helps people and their pets by gently and quickly spraying a patented and patent-pending ultra-purified, supersaturated solution on the skin surface to achieve major health benefits for well over 90% of users.

Experts call D’OXYVA a game-changer biotech. “Studies with D’OXYVA have shown unmatched results in noninvasive wound care,” Dr. Michael McGlamry. Anyone with an underlying condition should know this option is available.

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Reducing the Impact of COVID-19 Infection

D'OXYVA and the link between Covid-19 and a major long-term disease

More physical issues the Centers for Disease Control and Prevention (CDC) warns about include inflammation of the heart muscle, acute kidney injury, and hair loss. But a growing number of COVID patients seem to also be developing diabetes, which could need managing for the rest of their lives. Diabetes appears to be both a risk factor for COVID and a long-term effect of the illness.

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Mihail Zilbermint, MD, who cares for patients with metabolic disorders at Suburban Hospital in Bethesda, Maryland, recently told The Washington Post that his caseload has nearly doubled with patients recovering from COVID-19. “Before, we used to manage maybe 18 patients per day,” he said. Now, his team cares for as many as 30 daily.

Zilbermint described how many of the patients had no prior history of diabetes. Some developed elevated blood sugar levels while they were in hospital, which returned to normal by the time they were discharged. However, others were diagnosed with full-blown diabetes by the time they went home and some developed the disease in the weeks that followed. “We’ve definitely seen an uptick in patients who are newly diagnosed,” said the doctor.

Covid-19 May Be a Blood Vessel Disease, Which Explains Everything

Many of the infection’s bizarre symptoms have one thing in common

In April of 2020, blood clots emerged as one of the many mysterious symptoms attributed to Covid-19, a disease that had initially been thought to largely affect the lungs in the form of pneumonia. Quickly after came reports of young people dying due to coronavirus-related strokes. Next it was Covid toes — painful red or purple digits.

What do all of these symptoms have in common? An impairment in blood circulation. Add in the fact that 40% of deaths from Covid-19 are related to cardiovascular complications, and the disease starts to look like a vascular infection instead of a purely respiratory one.

NIH Study Uncovers Blood Vessel Damage and Inflammation in COVID-19 Patients’ Brains But No Infection

Results from a study of 19 deceased patients suggests brain damage is a byproduct of a patient’s illness

In an in-depth study of how COVID-19 affects a patient’s brain, National Institutes of Health researchers consistently spotted hallmarks of damage caused by thinning and leaky brain blood vessels in tissue samples from patients who died shortly after contracting the disease. In addition, they saw no signs of SARS-CoV-2 in the tissue samples, suggesting the damage was not caused by a direct viral attack on the brain. The results were published as a correspondence in the New England Journal of Medicine.

“We found that the brains of patients who contract infection from SARS-CoV-2 may be susceptible to microvascular blood vessel damage. Our results suggest that this may be caused by the body’s inflammatory response to the virus,” said Avindra Nath, M.D., clinical director at the NIH’s National Institute of Neurological Disorders and Stroke (NINDS) and the senior author of the study. “We hope these results will help doctors understand the full spectrum of problems patients may suffer so that we can come up with better treatments.”

Reducing the Impact of Comorbidities with COVID-19 Infection

Significant improvements in systemic circulation, especially in the critical microcirculation and microvessels with oxygen-balanced blood flow

In the middle of a global pandemic, like the one we’re living, it is highly relevant to be able to assess risk. This is not only important for seeing indications of infection susceptibility, but also to be better able to look for solutions to diminish the impact of risk factors in the infection rates and progression. We are not all equally vulnerable to the SARS-CoV-2, the virus responsible for the worldwide lock down that started late last year in China. Experience so far has shown that there is a series of factors that correlate with a worse prognosis, even leading to death.

According to the CDC (Centers for Disease Control and Prevention) and the NHS (National Health Systems) in the United Kingdom, the best known risk factors so far are:

⎯ A weak immune system (immunodeficiency), such as in those that have recently had a transplant, bone marrow recipients, cancer patients, those with poorly controlled HIV or AIDS, and those with prolonged use of corticosteroids or medications that lower immunity.

Old age. People over 65 years of age have been shown to suffer more and more often from coronavirus infection.

⎯ Chronic lung disease, such as chronic obstructive pulmonary disease (COPD) or asthma

⎯ Diabetes

⎯ Cardiovascular disease and/or serious heart conditions

⎯ Severe obesity (body mass index [BMI] of 40 or higher)

⎯ Chronic kidney disease undergoing dialysis

⎯ Liver disease

⎯ Pregnancy

⎯ Smoking

Most of these factors are quite common in the first world. In the United States, for instance, the prevalence of diabetes in the adult population is 10.1%. There is a similar prevalence of cardiovascular disease at 10.6%. Given these statistics, the great extent of at-risk populations in the United States becomes clear. Data from China also confirms the impact of comorbidities, such as respiratory disease, cardiovascular problems, and diabetes, on disease progression and the worsening of health outcomes in these patients.

Among these risk factors, cardiovascular disease and diabetes stands as two of the most dangerous ones. Reports from Chinese authorities and from top American institutions, such as the Harvard Medical School, show that underlying cardiovascular disease is associated with an increased risk of in-hospital death among patients hospitalized with COVID-19. It also seems that underlying cardiovascular disease also increases the probability of suffering from COVID-19 related cardiac problems, such as myocardial injury or arrhythmia. The full extent of the interplay between cardiovascular disease and COVID-19 is not yet known. However, it is clear that any means capable of improving cardiovascular health, both before and after infection, will go a long way in diminishing the deleterious effects of a coronavirus infection.

A recently discovered effect of COVID-19 infection is the development of potentially deadly blood clots. For instance, a Dutch team reported that out of 184 severe COVID-19 patients in intensive health units, about 31% had some sort of thrombotic episode. This is a remarkable proportion, which adds weight to the notion that improving blood perfusion and tissue oxygenation is of the utmost importance in diminishing the virus’ lethality.

So far, acute treatment of serious cases of COVID-19 has involved the use of blood thinners (anticoagulants), such as heparin, and oxygenation. However, there is a new treatment option available: D’OXYVA®.

D’OXYVA® is a groundbreaking completely painless and noninvasive transdermal delivery system shown to produce higher oxygen unloading by hemoglobin, thereby increasing oxygen-rich blood flow in the local microcirculatory system, which in turn leads to better blood perfusion and tissue oxygenation. Several clinical studies have demonstrated its effectiveness while reporting on zero side effects. Even where standard treatments have failed, D’OXYVA® achieves an improvement on health indicators like blood pressure, tissue oxygenation and wound healing. An additional advantage of is how easy it is to use it. There is no need for a clinical setting or additional expertise to use it. It can be applied even while sitting on the sofa watching your favorite show.

The evidence supporting the use of D’OXYVA® is manifold:

⎯ Three dozen human studies in the last eight years have reported zero adverse events associated with D’OXYVA® use. These studies run in collaboration with prestigious universities and hospitals around the world (including Penn State and Airlangga University) and are to be expanded in a recently IRB-approved pivotal trial.

⎯ D’OXYVA® pharmaceutical-grade carbon dioxide is FDA-approved and analogous to that available in hospitals and clinics.

⎯ Transdermal carbon dioxide has shown positive results in wound care in clinical studies. Healing, wound closure, and sepsis prevention and septic shock avoidance have been shown after D’OXYVA® application, even when other treatment modalities have failed.

⎯ Clinical data has also shown a consistent, significant decrease in systolic and diastolic blood pressure for up to 240 minutes after a single treatment with D’OXYVA®.

⎯ The perfusion index (PI) is the ratio of pulsating blood flow to static blood in peripheral tissue and acts as an indirect measure of blood peripheral perfusion, that is, how much blood reaches a particular tissue. This parameter is also greatly improved after D’OXYVA® application, as demonstrated in several clinical trials.

⎯ D’OXYVA® has also been shown to increase O₂ saturation in patients treated with transdermal CO₂ in comparison to controls for up to 2 hours after application.

⎯ Transdermal CO2 can successfully improve organ function (pancreas, liver, brain, and kidneys) and general health status in patients with hypertension.

In light of this evidence, it is clear that D’OXYVA® is a strong treatment option not only for those people already infected by the SARS-CoV-2 virus, with and without concomitant health risks, but also to everyone who wants to improve their health status and, thereby, decrease the potential physiological impact of the coronavirus. Obviously, people with underlying diseases and those at higher risk for COVID-19 will benefit even more from better tissue oxygenation. Improved microcirculation leads to better tissue oxygenation and better heart function, as the heart does not need to exert extra force to bring the blood to all the organs of the body.

Circularity Healthcare, the proprietary of the D’OXYVA® technology, is about to launch a significantly expanded multicenter pivotal human clinical trial to demonstrate that D’OXYVA® is a strong ally in the treatment of coronavirus patients. Initial study sites include the University of Harvard, Yale University, the Massachusetts Institute of Technology, the University of Southern California, and the University of California at Los Angeles. As monitoring can be performed at home, patients do not need to be hospitalized and can join the trial even with mild symptoms, which allows for long-term monitoring (up to four months) and characterization of parameters at various stages after infection.

The primary endpoint of the study is full recovery. Improvement in other health parameters, such as white and red blood cell count, angiogenesis, blood pressure and blood sugar levels, perfusion rates, and tissue and cell regeneration will be monitored.

Results of this trial will add to the mounting evidence supporting D’OXYVA® use as a coadjuvant in the treatment of COVID-19 patients, as it is clear that cardiovascular problems pose one of the biggest risks for coronavirus mortality, whereas proper tissue oxygenation via improved oxygen-rich blood flow counteracts these health risks, diminishing the effects of blood clotting and reducing the physical heart exertion needed to pump blood to organs like the brain, lungs, and others.

Reference(s)

COVID Could Give You This Lifelong Disease

https://elemental.medium.com/coronavirus-may-be-a-blood-vessel-disease-which-explains-everything-2c4032481ab2

https://www.nia.nih.gov/news/nih-study-uncovers-blood-vessel-damage-and-inflammation-covid-19-patients-brains-no-infection

https://www.ahajournals.org/doi/full/10.1161/circresaha.115.305364

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Experts say D’OXYVA® can help patients find relief. Preliminary medical data shows people with preexisting conditions, including diabetes may experience serious complications with COVID-19.D’OXYVA significantly helps people and their pets by gently and quickly spraying a patented and patent-pending ultra-purified, supersaturated solution on the skin surface to achieve major health benefits for well over 90% of users.Experts call D’OXYVA a game-changer biotech. “Studies with D’OXYVA have shown unmatched results in noninvasive wound care,” Dr. Michael McGlamry. Anyone with an underlying condition should know this option is available.

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Circularity Healthcare Announces Expansion with Global CRO of Series of Successful Pivotal Human Clinical Trials to Study Use of D’OXYVA® for Rapid, Economical and Noninvasive Home Treatment of Diabetic Foot Ulcers (DFU)

D'OXYVA | Blood Flow, Cardiovascular, Diabetes Care, Pain Relief in CA

Addressing urgent and increased health issues related to pandemic lockdowns and beyond.

PASADENA, Calif., Feb. 01, 2021 – Circularity Healthcare announced it had successfully executed a contract with the Professional Educational Research Institute (PERI) in 2020 to immediately begin a new clinical trial to study the use of D’OXYVA® to help prevent amputations and treat human diabetic foot ulcers at one-tenth the time and cost, and at least five times the efficacy of competing modalities.

A widely recognized global clinical research organization (CRO), PERI will specifically study at multiple sites at prestigious U.S. universities the use of D’OXYVA® to help address the recent epidemic of DFUs occurring in diabetic patients due to long-term pandemic quarantines and stay-at-home orders.

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Manufactured by Circularity, D’OXYVA® is a painless, noninvasive transdermal delivery system used in minutes to significantly improve blood perfusion, tissue oxygenation, and wound healing even where standard treatments have failed.

“D’OXYVA®‘s pivotal human clinical trial for complete healing of diabetic foot ulcers has been approved by the Western Institutional Review Board (WIRB), the largest in the world, and will include over a dozen high profile research sites at top U.S. universities and clinics,” said Senior Sales and Marketing Manager for Circularity, Jennifer Boadilla-Pelaez, RN. “Thousands of competing products in the past nearly twenty-five years have failed in achieving what D’OXYVA® has obtained in terms of regulatory approvals, clinical safety and efficacy in the past seven years. This is truly a game-changing milestone, not just for the company itself, but the entire medical community and the world and a preliminary report with meaningful results is expected within 6 months from starting the pivotal trial,” said Dr. Charles M. Zelen, PERI’s CEO.

DFUs are a major wound complication arising out of diabetes mellitus and occur in 3–13% of global diabetes patients, affecting millions of people. DFUs are caused by a variety of factors including decreased activity, diminished blood circulation, and people with underlying health conditions like diabetes are at higher risk for complications from COVID-19. Healthcare workers can expect to see far more instances of this persistent problem, especially with quarantine lockdowns, and it represents a significant health and economic risk to both patients and the overall healthcare system. Effective treatments that can reduce DFU recovery time, like D’OXYVA®, are absolutely crucial to combatting this newest wound epidemic.

About Circularity Healthcare LLC

Circularity Healthcare is an emerging world leader in proprietary circulatory health and noninvasive delivery technologies, committed to helping improve quality of life by developing, manufacturing, and marketing medical, pharmaceutical, and consumer health products. Circularity specializes in groundbreaking noninvasive technologies for affordable and portable transdermal delivery systems, and is currently pursuing regulatory approval worldwide as a way of treating cardiovascular and microcirculatory blood flow issues, as well as immune and autonomic nervous system disorders. Learn more at: https://doxyva.com/about-the-company/

About Professional Education and Research Institute, Inc.

PERI was established in 2005 as a premier CRO to manage Phase I – IV clinical trials around the world. PERI conducts clinical trials in both pharmaceutical and orthopedic research and performs specialty research in diabetic wound care, venous leg disease, neuropathy, peripheral vascular disease and gene therapy. One of the most unique advantages of choosing PERI as a partner in clinical trial management is a feature few CRO’s can match, which is our contracted sites throughout the United States, including IBC-certified sites. Learn more at: www.periedu.com

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Why Use D'OXYVA?

Experts say D’OXYVA® can help patients find relief. Preliminary medical data shows people with preexisting conditions, including diabetes may experience serious complications with COVID-19. D’OXYVA significantly helps people and their pets by gently and quickly spraying a patented and patent-pending ultra-purified, supersaturated solution on the skin surface to achieve major health benefits for well over 90% of users. Experts call D’OXYVA a game-changer biotech.

“Studies with D’OXYVA have shown unmatched results in noninvasive wound care,” Dr. Michael McGlamry. Anyone with an underlying condition should know this option is available.

Reduce unwanted doctor visits, recommended and ranked top by experts!

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This One Thing Makes You Twice as Likely to Die from Coronavirus

D'OXYVA Nurse
One pre-existing condition doubles your chances of death. Since the first cases of COVID-19 were identified in Wuhan, China, in December 2019, health experts have been attempting to determine why exactly, becoming infected with the virus proves deadly for some, while others show mild or even no symptoms. Over the last several months, they have pinpointed a variety of risk factors, ranging from age to heart health.
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Now, according to researchers from the NHS and Imperial College London, there is another preexisting condition that can heavily influence your death risk if infected with the coronavirus. Read on, and to ensure your health and the health of others, don’t miss these Sure Signs You’ve Already Had Coronavirus.

Obese People Are Twice as Likely to Die From COVID-19

One study claims that people who suffer from the coronavirus who have Type 2 diabetes—the most common form of diabetes—are twice as likely to die than those who do not suffer from diabetes. Those with Type 1 diabetes—the autoimmune form of diabetes—fare worse if infected. According to the study they are more than three-and-a-half times more likely to die. In total, researchers found that one-third of all COVID-19 deaths have one thing in common—diabetes.

Furthermore, those who are also severely obese, with a body mass index (BMI) above 40, are twice as likely to die than those who were obese or normal weight.

“This research shows the extent of the risk of coronavirus for people with diabetes and the different risks for those with type 1 and type 2 diabetes,” Prof Jonathan Valabhji, NHS England’s national clinical director for diabetes and obesity and the study’s lead author, said. “Importantly, it also shows that higher blood glucose levels and obesity further increase the risk in both types of diabetes.”

In other words, lifestyle choices can strongly influence your death risk when it comes to the highly infectious virus.

“This can be worrying news but we would like to reassure people that the NHS is here for anyone with concerns about diabetes—and has put extra measures in place to help people and keep them safe, including online sites to support people to care for themselves, digital consultations, and a dedicated new helpline for advice and support for people treated with insulin.

But You Can “Prevent or Delay” It

A previous study conducted by researchers at Wuhan Union Hospital published in the journal Diabetes Metabolism Research and Reviews, established a link between people with diabetes who contract COVID-19, and severe illness. Researchers found that patients who had diabetes but no other serious health problems were “more susceptible to an inflammatory storm eventually leading to rapid deterioration of COVID‐19.” This being at a “higher risk of severe pneumonia, release of tissue injury-related enzymes, excessive uncontrolled inflammation responses, and dysregulation of glucose metabolism” compared to patients without diabetes.

According to the Centers for Disease Control and Prevention, 34.2 million people of all ages—or 10.5% of the US population—have diabetes. The percentage of adults with diabetes increases with age, reaching 26.8% among those aged 65 years or older. The government health agency also points out that you can “prevent or delay” Type 2 diabetes even if you are genetically predisposed and at high risk via “proven, achievable lifestyle changes.” As for yourself: to get through this pandemic at your healthiest, don’t miss these 35 Places You’re Most Likely to Catch COVID.

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Why Use D'OXYVA?

Experts say D’OXYVA® can help patients find relief. Preliminary medical data shows people with preexisting conditions, including diabetes may experience serious complications with COVID-19. D’OXYVA significantly helps people and their pets by gently and quickly spraying a patented and patent-pending ultra-purified, supersaturated solution on the skin surface to achieve major health benefits for well over 90% of users. Experts call D’OXYVA a game-changer biotech.

“Studies with D’OXYVA have shown unmatched results in noninvasive wound care,” Dr. Michael McGlamry. Anyone with an underlying condition should know this option is available.

Reduce unwanted doctor visits, recommended and ranked top by experts!

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Diabetes drug recalled over excess levels of cancer-causing agent

Heads up, consumers: A diabetes drug is facing recall because the medication contains excess levels of a cancer-causing agent, the U.S. Food and Drug Administration (FDA) announced this week.

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Marksans Pharma Limited, a pharmaceutical company in India, announced an expanded recalled of its Metformin hydrochloride extended-release tablets, a drug used to help those who suffer from type 2 diabetes to lower their blood glucose levels. The recall, which was initially announced in June, was expanded on Monday to include an additional 76 unexpired lots of the medication.

An example of the recalled medication. (FDA)

“Marksans performed N-Nitrosodimethylamine (NDMA) testing of unexpired identified marketed lots and observed that NDMA content in some lots is exceeding the acceptable Daily Intake Limit (ADI) of 96ng/day, therefore, out of an abundance of caution, an additional 76 lots are being recalled,” the FDA said when announcing the recall.

NDMA is a “probable human carcinogen,” meaning it’s a substance that can lead to cancer, per the FDA.

“NDMA is a known environmental contaminant found in water and foods, including meats, dairy products and vegetables. Marksans Pharma Limited has not received any reports of adverse events that have been related to this recall,” the FDA said.

The recall impacts metformin tablets between 500 mg and 750 mg. The tablets were sold under the brand name Time-Cap Labs, Inc., according to the announcement.

The following products have been called back:

Metformin Hydrochloride Extended-Release Tablets, USP 500mg:

90 counts: 49483-623-09

100 counts: 49483-623-01

500 counts: 49483-623-50

1000 counts: 49483-623-10

Metformin Hydrochloride Extended-Release Tablets, USP 750mg:

100 counts: 49483-624-01

The 500 mg tablets are debossed with “101” on one side and are plain on the other. The 750 mg tablets, meanwhile, are also debossed with “102” on one side and are plain on the other, per the FDA.

“Consumers taking these recalled product lots of Metformin ER Tablets should continue taking it until a doctor or pharmacist gives them a replacement or a different treatment option. It could be dangerous for patients with type 2 diabetes to stop taking their metformin without first talking to their health care professional,” the FDA warned. The consumer “should contact their physician or healthcare provider if they have experienced any problems that may be related to taking or using this drug product.”

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Why Use D'OXYVA?

D’OXYVA® (deoxyhemoglobin vasodilator) is a validated microcirculation and nerve stimulant for people suffering from the damaging effects of moderate to advanced neuropathy.

Subjects suffering from high blood sugar have reported noticeable neuropathy pain relief only minutes after the D’OXYVA solution protocol, including long-term blood sugar level improvements in just a few weeks.

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Diabetic angiopathy: Impaired microcirculation in patients with diabetes mellitus

impared microcirculation in diabetic patients

Diabetes mellitus is a disorder of sugar metabolism.

The blood sugar level is regulated mainly by the hormone insulin. If the amount of insulin produced is insufficient (type 1 diabetes), or if the effect of insulin is reduced (type 2 diabetes), blood sugar levels are chronically elevated. After some time, this results in significant damage to blood vessels. The term used for this is therefore diabetic angiopathy. If larger blood vessels are affected, the risk of heart attack and stroke is increased. The microvascular changes caused by diabetes can also cause serious complications.

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Impaired microcirculation in patients with diabetes mellitus

Among the most feared long-term consequences of diabetic angiopathy are damage to the eyes (diabetic retinopathy), the kidneys (diabetic nephropathy) and the nerves (diabetic neuropathy).

Diabetic retinopathy is the main cause of blindness in middle age in Germany and other industrialized countries. The retina is supplied with nutrients and oxygen through very fine microvessels. Over time, diabetes can damage the microvessels so that this supply is no longer sufficient. Affected persons at first see everything blurred, as though through a veil. In advanced stages, pronounced vision disorders and even blindness may develop. According to estimates by the German Diabetes Society, 20 to 40 percent of diabetics suffer kidney damage in the course of their disease. One of the tasks of the kidneys is to filter toxins and waste products out of the blood so they can be excreted in the urine. This work is done via tiny blood vessels in the renal corpuscles. Persistently high blood sugar levels damage these microvessels.

As a result, the filtering capacity of the kidney is reduced and the body is no longer sufficiently detoxified. If left untreated, this can lead to chronic renal failure so that renal functions must be replaced by dialysis or a kidney transplant. Approximately 30 percent of diabetes patients suffer nerve damage. One cause of this is impaired nerve cell metabolism due to high blood sugar levels. Another factor is reduced oxygen supply to the nerve cells due to the damaged microvessels supplying them. The most evident consequences are abnormal sensations like tingling, burning pain or numbness, especially in the hands and feet. In addition, tactile and temperature sensations, as well as pain perception, may be reduced. This latter factor favours the  development of diabetic foot syndrome since wounds are not noticed in early stages and – also due to impaired microcirculation – heal poorly.

LONG-TERM DAMAGE RESULTING FROM IMPAIRED MICROCIRCULATION IN PATIENTS WITH DIABETES MELLITUS

• Damage to eyes (diabetic retinopathy) with vision impairments

• Damage to renal function (diabetic nephropathy), possibly mandatory dialysis

• Nerve damage (diabetic neuropathy) with abnormal sensations and impaired pain perception

• Impaired wound healing (diabetic foot syndrome)

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How Can D'OXYVA Help?

According to Dr. Michael McGlamry of  Forsyth Foot and Ankle Associates, Cumming, GA, D’OXYVA® (deoxyhemoglobin vasodilator) is a groundbreaking noninvasive, painless transdermal delivery system based on widely established, groundbreaking, Nobel Prize-winning science and is shown to increase oxygen-rich blood flow in the local microcirculatory system, which in turn leads to better blood perfusion and tissue oxygenation. The increased peripheral perfusion plays a significant role in enhancing the wound healing process, which may lead to a reduction in the influence of preexisting conditions in cases of a coronavirus infection.

D’OXYVA has shown significant promise for severe cases of diabetic foot ulcers. Its therapeutic effects have circulatory and neurological benefits as well.

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How D'OXYVA Works?

For example, D’OXYVA® naturally delivers remarkable and fast pain management results without the use of opioids. In high-quality studies, it has demonstrated noticeable efficacy in the reduction and elimination of chronic pain — achieving over 90% elimination of all varieties of chronic pain in nearly all enrolled subjects the same day or in a few days.

D’OXYVA® (deoxyhemoglobin vasodilator) is a handheld applicator that’s the first biotech solution of its kind, underpinned by widely established, groundbreaking, Nobel Prize–winning science.

It’s been studied to significantly improve macro-, and micro-circulation of blood flow and certain nerve activities in the body, which is widely reported to boost fitness and form an effective noninvasive, pain-free solution for several widespread conditions.

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Company shares shocking model of future remote worker as pandemic continues

Millions of American workers became remote employees overnight when the coronavirus pandemic hit earlier this year, and the future isn’t looking too bright for those who fail to maintain healthy habits while working from home in the long-term, new findings claim.

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Job discovery platform DirectlyApply recently unveiled a visual model for what future remote workers might look like in 25 years if they don’t reform bad habits now, in a figure they’ve named Susan.

Suffering from digital eye strain, poor posture, “tech neck,” obesity, increased stress due to lack of human contact and more, Susan dramatically exemplifies the physical repercussions remote workers may suffer if they fail to prioritize their physical and mental health beyond their 9 to 5.

work from home
Suffering from digital eye strain, poor posture, tech neck, obesity, increased stress due to lack of human contact and more, Susan dramatically exemplifies the physical repercussions remote workers may suffer if they neglect to keep healthy habits.

Susan was created in partnership with a team of clinical psychologists and fitness experts to highlight the effects that isolated working can have on the body, according to DirectlyApply.

“With lockdown having forced people across the globe into what has been the world’s largest remote working experiment, our usual interpretation of the perk has been transformed forever,” a spokesperson for the job-searching site said in a statement shared with Fox News. “Whilst your bed-to-desk commute may allow for more free time and independence, will the physical repercussions to your mind and body be worth it in the future?”

With that being said, the London-based job searching site, which also operates in the U.S. and Canada, shared positive tips for improving physical and mental health while working remotely, amid an uncertain future.

To improve health and wellness during this time, remote workers are encouraged to stick to a routine to optimize productivity, nurture (virtual) social connections with colleagues, exercise outside, clearly delineate between working and living spaces to promote a healthy work-life balance and use free time wisely to support emotional health.

HOW D’OXYVA® CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless over-the-skin microcirculatory and nerve stimulant solution that has been validated to significantly improve microcirculation.The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways, including but not limited to weight loss, recover from injury, improved performance, besides diabetes and heart health.

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Scientists just beginning to understand the many health problems caused by COVID-19

CHICAGO – Scientists are only starting to grasp the vast array of health problems caused by the novel coronavirus, some of which may have lingering effects on patients and health systems for years to come, according to doctors and infectious disease experts.

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Besides the respiratory issues that leave patients gasping for breath, the virus that causes COVID-19 attacks many organ systems, in some cases causing catastrophic damage.

“We thought this was only a respiratory virus. Turns out, it goes after the pancreas. It goes after the heart. It goes after the liver, the brain, the kidney and other organs. We didn’t appreciate that in the beginning,” said Dr. Eric Topol, a cardiologist and director of the Scripps Research Translational Institute in La Jolla, California.

In addition to respiratory distress, patients with COVID-19 can experience blood clotting disorders that can lead to strokes, and extreme inflammation that attacks multiple organ systems. The virus can also cause neurological complications that range from headache, dizziness and loss of taste or smell to seizures and confusion.

And recovery can be slow, incomplete and costly, with a huge impact on quality of life.

The broad and diverse manifestations of COVID-19 are somewhat unique, said Dr. Sadiya Khan, a cardiologist at Northwestern Medicine in Chicago.

With influenza, people with underlying heart conditions are also at higher risk of complications, Khan said. What is surprising about this virus is the extent of the complications occurring outside the lungs.

Khan believes there will be a huge healthcare expenditure and burden for individuals who have survived COVID-19.

LENGTHY REHAB FOR MANY

Patients who were in the intensive care unit or on a ventilator for weeks will need to spend extensive time in rehab to regain mobility and strength.

“It can take up to seven days for every one day that you’re hospitalized to recover that type of strength,” Khan said. “It’s harder the older you are, and you may never get back to the same level of function.”

While much of the focus has been on the minority of patients who experience severe disease, doctors increasingly are looking to the needs of patients who were not sick enough to require hospitalization, but are still suffering months after first becoming infected.

Studies are just getting underway to understand the long-term effects of infection, Jay Butler, deputy director of infectious diseases at the U.S. Centers for Disease Control and Prevention, told reporters in a telephone briefing on Thursday.

“We hear anecdotal reports of people who have persistent fatigue, shortness of breath,” Butler said. “How long that will last is hard to say.”

While coronavirus symptoms typically resolve in two or three weeks, an estimated 1 in 10 experience prolonged symptoms, Dr. Helen Salisbury of the University of Oxford wrote in the British Medical Journal on Tuesday.

Salisbury said many of her patients have normal chest X-rays and no sign of inflammation, but they are still not back to normal.

“If you previously ran 5k three times a week and now feel breathless after a single flight of stairs, or if you cough incessantly and are too exhausted to return to work, then the fear that you may never regain your previous health is very real,” she wrote.

Dr. Igor Koralnik, chief of neuro-infectious diseases at Northwestern Medicine, reviewed current scientific literature and found about half of patients hospitalized with COVID-19 had neurological complications, such as dizziness, decreased alertness, difficulty concentrating, disorders of smell and taste, seizures, strokes, weakness and muscle pain.

Koralnik, whose findings were published in the Annals of Neurology, has started an outpatient clinic for COVID-19 patients to study whether these neurological problems are temporary or permanent.

Khan sees parallels with HIV, the virus that causes AIDS. Much of the early focus was on deaths.

“In recent years, we’ve been very focused on the cardiovascular complications of HIV survivorship,” Khan said.

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HOW D'OXYVA CAN HELP?

Expert say D’OXYVA can help COVID-19 patients find relief. Preliminary medical data shows people with pre-existing conditions including diabetes may experience serious complications from COVID-19.

D’OXYVA helps by delivering transdermal ultra-purified medical gas directly to the blood stream delivering major outcomes for well over 90% of users.

Experts call D’OXYVA a gamechanger.

“Studies with D’OXYVA have shown unmatched results in noninvasive woundcare,” Dr. Michael McGlamry.

Anyone with an underlying condition should know this option is available.

physician-recommended easy to use daily

HOW D'OXYVA CAN HELP?

Expert say D’OXYVA can help COVID-19 patients find relief. Preliminary medical data shows people with pre-existing conditions including diabetes may experience serious complications from COVID-19.

D’OXYVA helps by delivering transdermal ultra-purified medical gas directly to the blood stream delivering major outcomes for well over 90% of users.

Experts call D’OXYVA a gamechanger.

“Studies with D’OXYVA have shown unmatched results in noninvasive woundcare,” Dr. Michael McGlamry.

Anyone with an underlying condition should know this option is available.

Reduce unwanted doctor visits, recommended and ranked top by experts!

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An exclusive interview with Dr. Geoffrey Watson, MD: Diabetic patients and Covid-19

Dr. Watson interview D'OXYVA

About Dr. Geoffrey Watson

Watson Wellness Center in Oakland, CA

A native and resident of Oakland, California, Geoffrey Watson obtained a Bachelor of Science in Health Care Administration from the University of California at Davis and a medical degree from Vanderbilt University in Nashville, Tennessee. Dr. Watson completed two years of his medical residency at the Vanderbilt Medical Center with his final year of medical residency completed at the University of California Medical Center in San Francisco. In 1985, Dr. Watson started his medical career in Oakland as a specialist in the art of Internal Medicine working as a staff physician at the Arlington Medical Center alongside his father, Dr. James A. Watson.

Dr. Watson has a special interest in education and has earned the position of Director of Continuing Medical Education at Fairmont Hospital in San Leandro and Alameda County Medical Center of the East Bay. In 1992, as a Board Certified Internist, his love for teaching and medical education has earned him a position as Assistant Clinical Professor of Medicine at the U.C.S.F. Medical Center. Also in 1992, as the Co-Medical Director of the Arlington Medical Center, Dr. Watson became a key player in the Oakland community as a leader in managed care and positioned himself as a Founding Member of the Alta Bates Medical Associates. He developed medical groups, leading the way in managed care, and helped to organize a merger of prominent physicians resulting in a powerful African American Primary Care Group geared towards serving the needs of African Americans in the East Bay, including the development of preventive care programs focused in the areas of hypertension, asthma, diabetes, heart disease, substance abuse and weight control.

Dr. Watson has served as the Secretary for the Sinkler Miller Medical and the Golden State Medical Associations during 1994. In May, 1997, he was inaugurated into office as President of the Golden State Medical Association and served through 1998. From 1996 through 1997 he has been honored with serving as the President of the Sinkler Miller Medical Association of the East Bay. On March 1, 1997, Dr. Watson established a new medical facility, The James A. Watson Wellness Center, a legacy of his father, moving his practice to Pill Hill and continuing to provide high quality and sensitive care to patients by treating the physical, socioeconomic, spiritual and psychological ailments and employing medical and practical solutions with hopes of resulting in complete wellness.

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1. What should patients with diabetes know about COVID-19 and how it may affect them?

Those people who are at the highest risks of contracting COVID-19, are those over the age 65, have heart disease, liver disorders, diabetes and other underlying health issues. Because it effects the immune system and compromises the bodies natural defenses fight off infections, it is critical for a person with diabetes to have good blood flow circulation, reducing the chance of infection, ulcers and at worse case amputations.

2. How does Circularity’s D’OXYVA help patients with foot issues, potentially including COVID-19?

D’OXYVA®  (deoxyhemoglobin vasodilator) is validated to significantly improve macro-, and micro-circulation of blood flow and certain nerve activities in the body, which together are widely reported to form an effective non-invasive, pain-free solution option for many conditions. It provides accelerated and comprehensive wound care — plus infection protection — in a painless, affordable non-prescription solution available in a clinical setting, or in the comfort and privacy of your own home.

D’OXYVA has shown significant promise for severe cases of diabetic foot ulcers. Its therapeutic effects have circulatory and neurological benefits as well.

3. Tell us about CO2, microcirculation, and its effects on the body.

D’OXYVA uses ultra-purified carbon dioxide, which has been shown to produce higher oxygen unloading by hemoglobin, thereby increasing oxygen-rich blood flow in the local microcirculatory system. This improved dermal microcirculation leads, in turn, to enhanced wound healing.

Good blood circulation has many important health benefits. Among the most prominent is the optimal oxygenation of bodily tissues and organs, which allows for efficient functioning of the heart, lungs and muscles. Active blood circulation also improves the immune response against disease by allowing the better transportation of white blood cells throughout the body. Furthermore, proper blood circulation improves cellular detoxification, while waste removal becomes more efficient. Among its other health benefits, D’OXYVA has been also studied as a successful means of improving the autonomic nervous system.

4. What have clinical trials shown about how D’OXYVA helps patients, especially diabetics with foot problems?

Studies with D’OXYVA have shown increased oxygen concentration and lower carbon dioxide concentration in the blood just 30 minutes after treatment that can last over 60 minutes. Over two dozen studies demonstrated convincing results at clinics and at home with no adverse events.

Many treatments make bold online claims to help cure various conditions and restore you to health — pills, shots, creams, procedures, and devices. But only science-backed, one-of-a-kind D’OXYVA stands alone, delivering the remarkable physical, mental, and emotionally rejuvenating results.

5. As a Internist ­focused on prevention, what do you want diabetics to know about making their foot health a priority?

The heart is the engine that makes the body function. The foot though a far distance from the heart requires consistent blood flow. It requires open pathways. If those pathways are constricted, which is fairly normal occurrence with diabetic patients, those areas have a tendency to die off, because of the poor blood circulation. That is why it is key to some type of vasodilation to promote microcirculatory blood flow to supply adequate oxygenation the the feet. There by likely helping to prevent infections, ulcers and wounds.

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Why Use D'OXYVA?

Increasing demand for painless drug delivery, coupled with rising demand for self-administration of drugs, is anticipated to fuel market growth. D’OXYVA® (deoxyhemoglobin vasodilator) is the only fully non-invasive, non-irritating, non-opioid, and completely painless, over-the-skin delivery nerve stimulant and microcirculatory solution with over seven years of industry-leading research results.

D’OXYVA® has been demonstrating for years that it does not break the skin’s barrier, while it provides exceptional quality of life and health benefits quickly and affordably. In short, based on current leading neurology, immunology, microvascular, and cellular oxygenation science, D’OXYVA® is leading the field by:

Significantly lowering the risk of diabetes and cardiovascular complications.

Providing complete significant improvement of difficult wounds together with major pain relief and improved quality of life.

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How a New Advanced Health Solution Underpinned by Nobel-winning Science Can Protect You by Targeting Underlying Conditions

Covid-19 underlying medical conditions

Patients dealing with underlying health issues, including diabetes and chronic heart conditions, as well as COVID-19, may find fast and painless relief from an advanced solution.

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An easy-to-use , commercially-available device, D’OXYVA (deoxyhemoglobin vasodilator) by Circularity Healthcare, LLC, delivers transdermal ultra-purified medical gas directly to the blood stream and body tissues that are low in oxygen-rich blood flow.

The handheld, lightweight device – which promotes  the rest and digest functions of the autonomic nervous system  and the circulation of the blood in the smallest blood vessels, known as microcirculation – has demonstrated over years of studies and user feedback great efficacy in treating a number of health issues, including treating and closing so-called non-healing diabetic wounds.

D’OXYVA has shown significant promise for severe cases of diabetic foot ulcers,” says Dr. Michael McGlamry, a podiatrist in Georgia.

He says the device helps increase oxygen-rich blood flow in the local microcirculatory system, leading to better blood perfusion and tissue oxygenation.

“Improved microcirculation leads to better tissue oxygenation and better heart function, as the heart does not need to exert extra force to bring the blood to all the organs of the body,” says Dr. McGlamry.

Wound healing

Foot wounds are a significant concern for diabetics: 15% will develop a foot ulcer, and 14-24% of individuals with a foot ulcer, will need amputation.

Dr. Felix Sigal, a Los Angeles podiatrist, says this device is a game changer.

“Transdermal delivery of carbon dioxide has therapeutic effects on both the microcirculation and tissue oxygenation,” he says. “By improving tissue oxygenation and microcirculation, studies have shown greater progress in wound healing with respect to wound size and area of injury.”

The device was evaluated over eight years and three dozen human studies where zero adverse effects were reported. The CO₂ is approved by the FDA for anesthesia and oxygen therapy as a non-toxic, simple molecule under the Medical Gas Safety Act of 2012. It’s in the final phase of getting a combination device-drug approval.

“D’OXYVA has recorded significant results, delivering major outcomes for well over 90% of users,” says Dr. McGlamry.

Applications for COVID-19 patients

The device may help improved blood flow and tissue oxygenation for people with COVID-19 . Patients most at risk for the novel coronavirus include those over 65 who have heart disease, liver disorders, diabetes or other underlying health issues.

“Because it affects the immune system and compromises the body’s natural defenses fight off infections, it is critical for a person with diabetes to have good blood flow circulation, reducing the chance of infection, ulcers and at worst case amputations,” says Dr. Geoffrey Watson, who specializes in chronic care management in Oakland, California.

He says while the heart is a far distance from the foot, the foot relies on the heart for consistent blood flow, requiring open pathways. Often those pathways are constricted in diabetics, resulting in poor blood circulation

Dr. Watson says vasodilation is essential, “to promote microcirculatory blood flow to supply adequate oxygenation the feet, thereby likely helping to prevent infections, ulcers and wounds.”

Clinical Trial

Circularity Healthcare’s pivotal clinical trial — which involves the use of an FDA-approved drug in addition to IDE device D’OXYVA® (deoxyhemoglobin vasodilator), a non-toxic, non-invasive  transdermal drug delivery device — is poised to help the most at-risk coronavirus patients experiencing complications due to diabetes, poor circulation, hypertension, high blood pressure, and cardiovascular disease.

“Further studies are needed but this device has the potential to prevent symmetrical peripheral gangrene, a limb threatening complication of COVID-19,” says Dr. Sigal, who is helping conduct the D’OXYVA pivotal diabetic foot ulcer clinical trials.

This clinical trial represents the first biotech solution to improve a patient’s overall oxygen-rich blood flow.

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physician-recommended, easy to use daily

Why Use D'OXYVA?

Experts say D’OXYVA® can help patients find relief. Overwhelming medical data shows people with preexisting conditions, including diabetes may experience serious complications with COVID-19.

D’OXYVA significantly helps people and their pets by gently and quickly spraying a patented and patent-pending ultra-purified, supersaturated solution on the skin surface to achieve major health benefits for well over 90% of users.

Experts call D’OXYVA a game-changer biotech. “Studies with D’OXYVA have shown unmatched results in noninvasive wound care,” Dr. Michael McGlamry. Anyone with an underlying condition should know this option is available.

Reduce unwanted doctor visits, recommended and ranked top by experts!