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New CDC data shows danger of coronavirus for those with diabetes, heart or lung disease, other chronic conditions

Most Frequently Administered Drugs in the U.S. Are Not What You Think

People who have chronic medical conditions, such as diabetes, lung disease and heart disease, face an increased chance of being hospitalized with covid-19 and put into intensive care, according to data released Tuesday by the Centers for Disease Control and Prevention that is consistent with reports from China and Italy.

The new data gives the most sweeping look at the way covid-19 is causing serious illnesses among people in the United States who already face medical challenges.

The report reinforces a critically important lesson: Although the disease is typically more severe among older people, people of any age with underlying medical conditions are at increased risk if they contract the virus, for which there is no vaccine or approved drug treatment. 

The CDC data is an initial description of how the disease appears to be affecting people who are already dealing with health challenges. The study did not break down the disease demographically, for example by age, sex, race or income. The agency also notes that this is essentially a snapshot and can’t capture the ultimate outcome for people who have been infected with the virus and haven’t yet recovered.

The report shows covid-19 is thrusting vulnerable people in the United States into intensive care units and disproportionately taking the lives of people who already face medical challenges.

The CDC analyzed more than 7,000 confirmed covid-19 cases across the country in which health officials had a written record about the presence or absence of any underlying medical condition. The preexisting conditions covered in the records include heart and lung diseases, diabetes, chronic renal disease, chronic liver disease, immunocompromised conditions, neurological disorders, neurodevelopmental or intellectual disability, pregnancy, current or former smoker status, and “other chronic disease.”

The CDC found that, of people requiring admission to an intensive care unit, 78 percent had at least one underlying health condition. Of people hospitalized but not requiring ICU admission, 71 percent had at least one such condition, compared with just 27 percent of people who didn’t need to be hospitalized.

Among all the cases analyzed, 10.9 percent of patients had diabetes mellitus, 9.2 had chronic lung disease and 9 percent had cardiovascular disease.

The report did not reach any conclusion about whether the severity of an underlying condition correlated to a more severe covid-19 illness.

Of the 7,160 patients whose chronic illness status was known through health records, 184 died, and 173 of them had an underlying condition, the CDC said. None of the deaths were among people under age 19.

Covid-19 is a respiratory disease. The virus typically infects the upper respiratory tract, but it can also venture deeper into the lungs and in some patients results in pneumonia-like symptoms, requiring hospitalization and sometimes intubation on a ventilator. People who smoke or have chronic lung conditions are especially vulnerable.

Diabetes and heart disease are similarly worrisome. Someone already suffering from heart problems — whether they had previous heart attack or required a stent installed because of plaque buildup in their vascular system — may have a heart that cannot take as much strain as the average person, said Amesh Adalja, an infectious disease physician at Johns Hopkins Center for Health Security.

When a patient gets infected with something like this coronavirus, the fever causes a spike in the heart rate. Shortness of breath means the patient gets less oxygen. People with limited cardiac capacity can go into arrest.

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Diabetes is a metabolic syndrome that involves blood glucose levels and affects how the immune system works, and makes it less effective, Adalja said.

“This is why patients with diabetes are at risk for many infections not just coronavirus,” Adalja said. “They often struggle with infections on their skin and soft tissues, with pneumonia and even more serious conditions.”

Those in the high risk group need to be extremely careful.

“If they do become infected, the threshold for them seeking medical attention needs to be much lower. They and their clinicians have to keep this in mind,” Adalja said. “These numbers show us just how crucial that is.”

Wilbur Chen, an infectious-disease physician at the University of Maryland, added that while the virus seems to prey on the elderly and sick, “it does not mean it does not cause severe illness in younger adults or in children — in other words, the risk is not zero among the young.”

He said, “We are now documenting a large number of covid-19 infections across the U.S. and we are now observing more and more of these ‘rare’ events of severe illness and even deaths among the young.”

Reference:

https://www.msn.com/en-us/news/medical/new-cdc-data-shows-danger-of-coronavirus-for-those-with-diabetes-heart-or-lung-disease-other-chronic-conditions/ar-BB11YPUv

HOW D’OXYVA CAN HELP?

D’OXYVA works to prevent sepsis, and resulting septic shock, using life-restoring molecule carbon dioxide (CO₂) and gentle vapor dissolved across the skin in a fast, painless, handheld  5-minute application — performed either in a clinical setting or in the comfort and privacy of your own home.

D’OXYVA is the only fully noninvasive, completely painless over-the-skin microcirculatory and nerve stimulant solution that has been validated to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

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7 Things You Should Know About Diabetic Foot Care

Photomicrography

Diabetes can lead to complications[1] involving the feet, including peripheral neuropathic pain, diabetic foot ulcers, poor circulation, decreased sensation and increased callus formation. This can lead to skin breakdown and the formation of ulcers that can become infected and even lead to amputations. Proper diabetic foot care can decrease the risk of developing these complications. Read on to learn about the case of Chase L., who suffered from severe diabetes with complications involving both feet and who experienced significant pain relief through the application of the non-invasive deoxyhemoglobin vasodilator D’OXYVA[2]

Chase was a 64-year-old male patient with a 7-year history of type 2 diabetes mellitus. He had high blood sugar levels for a 3-year period before his diagnosis, as well as a history of elevated cholesterol and triglycerides and high blood pressure. On laboratory testing, Chase had an A1C level of 8.3% (normal A1C levels are less than 5.7%) and a blood sugar reading of 186 (normal readings are 70-110). 

On physical exam, Chase exhibited ingrown toenails, pallor of the feet, cyanosis of the toes and thick callus formation of the heels. In addition, he had decreased sensation over the dorsum of both feet and diminished pedal pulses bilaterally. After spending thousands of dollars on medications and trying various non-invasive treatments without relief, Chase experienced significant pain relief and a decrease in the cyanosis of his toes after 6 weeks of daily D’OXYVA applications and shared that he saved money by using D’OXYVA and beginning to wean off of other medications. 

1 Check Your Feet Carefully Every Day for Diabetes Induced Changes

Diabetic patients must check their feet carefully every day to look for suspicious areas of skin breakdown, color changes, callus formation and skin infections. Areas that are especially vulnerable to skin breakdown include the big toe, the heel and the areas between the toes. Diabetics are extremely vulnerable to damage to the microcirculation (smallest blood vessels) of the feet. The application of transdermal vasodilators such as D’OXYVA can increase peripheral oxygenation to avoid further nerve damage and other diabetes induced changes while improving wound healing and avoiding amputations.

2 Wear Properly Fitting Shoes

Shoes that are too tight can impair circulation. Care should be taken to ensure a proper fit so that circulation is adequate and there is no inordinate friction or rubbing.

3 Keep Your Feet Dry, Especially in the Winter

Excessive moisture caused by sweating of the feet can lead to increased bacteria growth, which can cause infections. Socks should be changed regularly in the winter especially, if they become wet.

4 Use Moisturizer on Your Feet After Bathing

The nerve damage and vascular changes to the feet caused by diabetes lead to dysfunction of the moisturizing glands and result in increased dryness, which can cause further skin breakdown. Applying a moisturizer to the feet (but not between the toes) after bathing can restore lost moisture and reduce dryness.

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References

1. https://www.diabetes.org/diabetes/complications/foot-complications
2. https://doxyva.com/

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless over-the-skin microcirculatory and nerve stimulant solution that has been validated to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

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Top 10 Myths About Diabetes Treatments: Busted

Myths About Diabetes Treatments

Diabetes affects tens of millions of Americans, with hundreds of thousands of new cases diagnosed every year. And there are many different currently accepted treatments for diabetes. However, there are also many myths about diabetes treatments that can confuse patients. Therefore, debunk the top ten myths about diabetes treatments by reading on to learn more about this underlying condition and about a diabetic patient, Mary. She was confused about her diabetes treatments and struggled to keep her blood sugar levels under control.

Mary is a 25-year-old female who had developed high blood sugar. Since she was slightly obese and had a history of hypertension and high cholesterol, she believed that only diet and exercise could help her lower her blood sugar. However, Mary’s physician recommended using applications of D’OXYVA[1] deoxyhemoglobin transdermal vasodilator that takes 5 minutes a day, 5 times per week for 3 months. At the end of this period, Mary had lowered her blood sugar levels back to normal.

Diabetes Treatments Myth #1

It Is Not Important to Check Blood Sugar as Directed During Diabetic Treatment


This is false.

Many patients erroneously believe that they can “tell” their blood sugar levels simply by how they feel. The fact is that not carefully monitoring for hypoglycemia or hyperglycemia by checking blood sugar as directed by your physician can lead to complications, which can include coma or death.

Diabetes Treatments Myth #2

If You Need Insulin, It Is Because You Failed to Diet and Exercise Properly


This is false.

When you have type 2 diabetes, it is because your pancreas fails to produce an adequate amount of insulin. This may require taking insulin injections if oral medications fail, but it is not because you did anything wrong.

Diabetes Treatments Myth #3

If You Are Taking Diabetic Medication, Your Diet Doesn’t Matter


This is false.

You still need to follow a healthy diet to ensure the best blood sugar control.

Diabetes Treatments Myth #4

If You Are on Diabetic Medication, You Can’t Lead an Active Lifestyle

This is false.

According to the American Diabetic Association,[2] 30 minutes of brisk walking, swimming or other aerobic exercises at least 5 days per week helps control blood sugar levels.

Diabetes Treatments Myth #5

Using Insulin Means Your Limbs May be Amputated


This is false.

Insulin lowers blood sugar levels, which reduces the risk of a limb amputation.

Diabetes Treatments Myth #6

All Diabetic Patients Should Take the Same Medications


This is false.

Different patients will require different diabetic medications depending on what works best for them.

Diabetes Treatments Myth #7

It is Necessary to Lose Large Amounts of Weight to Lower Blood Sugar Levels


This is false.

If you lose from 5 to 10% of your body weight, it can make a significant difference in your blood sugar level.

Diabetes Treatments Myth #8

Everyone With Diabetes Will End Up With Neuropathy (Nerve Damage)


This is false.

Good blood sugar control and significantly improve your microcirculation can help prevent complications from diabetes. Improved microcirculation acts as a nerve stimulant for people suffering from the damaging effects of moderate to advanced neuropathy

Diabetes Treatments Myth #9

Everyone With Diabetes Will End Up Blind


This is false.

Good blood sugar control and sufficient microcirculation to the eyes can help prevent eye complications from diabetes.

Diabetes Treatments Myth #10

Everyone With Diabetes Will End Up With Kidney Failure


This is false.

Good blood sugar control and significantly improve microcirculation to organs affected can help prevent further organ complications from diabetes.

References

  1. https://doxyva.com/
  2. https://www.diabetesdaily.com/blog/adas-new-physical-activity-and-exercise-guidelines-for-people-with-diabetes-317836/
  3. https://www.drugtopics.com/latest/fda-investigating-ndma-metformin

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless over-the-skin microcirculatory and nerve stimulant solution that has been validated to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

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Always Ready to D’OXYVA, Never Have to Order

Circularity Healthcare’s Autopay-Autoship Program means your D’OXYVA supplies are always on-hand right-here, right-now. You already know that D’OXYVA’s daily continued application for at least 8 weeks has been proven to deliver greater results for your physical restoration and mental renewal for an enhanced overall quality of life.

Now you can skip the website, cart and checkout process and receive a 6-month supply of D’OXYVA Easytwist cartridges delivered directly to your doorstep automatically — plus, enjoy FREE shipping on your order and savings up to $360 off the regular order price.

Circularity Healthcare’s D’OXYVA Autopay-Autoship Program includes 6 months of D’OXYVA supplies for $179 per month, payable with any major banking card or your PayPal account.

This convenient, reliable, and affordable program, now in its second decade of operation, was born of Circularity Healthcare’s unwavering commitment to serving its customers with the utmost care and support.

“We never stop thinking about our customers satisfaction — this program is only one of the many programs we have in place that our customers can choose from that will fit to their needs,” says Jennifer Boadilla-Pelaez, Senior Sales and Marketing Manager, and Creative Director of Circularity Healthcare.

For more information and to start your Circularity Healthcare’s D’OXYVA Autopay-Autoship Program, click the button below.

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless over-the-skin microcirculatory and nerve stimulant solution that has been validated to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

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The Next Big Thing in Diabetic Foot Pain Management

Family measuring D'Oxyva Perfusion Index (peripheral blood circulation), oxygen saturation, heart rate, respiratory rate results with special oximeter

Diabetes Mellitus Type 2 is a severe, chronic medical condition that affects approximately 23.1 million[1] patients in the United States (9.4% of the US population). In addition, each year, 800,000 people will be newly diagnosed with diabetes. Diabetes can lead to the development of blindness, strokes, end stage renal disease, heart disease and diabetic neuropathy. Read on to learn about the case of Leo, who suffered from severe diabetic peripheral neuropathy.

Case of a Patient with Diabetic Foot Pain

Leo was a 64 year old male patient with a long history of diabetes type 2.

Leo had a history of smoking cigarettes for the past 25 years.

He also had a history of hypertension, which was well controlled with lisinopril.

In addition, Leo had elevated cholesterol levels controlled with the use of a statin.

He denied any history of anxiety or depression.

Leo complained of a burning, very painful feeling in his hands and feet, which kept him up at night.

He also had some problems maintaining his balance and noted attacks of burning pain on the soles of his feet, often when driving his car.

On physical examination, Leo exhibited ataxia, vertigo and decreased vibratory sensations over his lower extremities.

His reflexes and the pedal pulses of the lower extremities were both intact bilaterally.

Leo’s labs revealed a fasting blood sugar of 146 and a hemoglobin A1C level of 7.8% (normal is less than 5.7%).[2]

Leo’s B12, T3, T4 and TSH levels were all within normal levels.

He also had a BMI of 40%.

After application of the over-the-skin deoxyhemoglobin peripheral vasodilator, D’OXYVA, [3] over a 6 week period, all of Leo’s symptoms of diabetic neuropathy, including the burning, itching and painful feeling in his hands and feet stopped completely.

How is the Microcirculation Affected by Diabetes?

The microcirculation consists of the smallest blood vessels in the body, including the arterioles, venules and capillaries.

Consistently elevated blood sugar levels are considered to be the most important risk factor in the development of painful diabetic neuropathy.

Diabetic neuropathy usually begins to develop at the base of the toes and then subsequently affects the higher parts of the lower extremities.

The most common symptoms of diabetic neuropathy include numbness, a feeling of burning, tingling and “pins and needles.”  

Other symptoms of diabetic neuropathy are muscular weakness of the lower extremities, poor coordination and ataxia.

Once the numbness increases, there can then be a loss of pain perception, which can lead to the development of foot ulcers, infections and even eventual amputations.  

How Does D’OXYVA Help Decrease Diabetic Foot Pain?

D’OXYVA is a non-invasive vasodilation applicator, which is placed over the thumb and delivers a vapor of pharmaceutical grade CO2 and water through the skin of the thumb and into the blood stream.

This COis then transported by the microcirculation to the peripheral arterioles, which causes them to dilate, providing increased oxygen to the peripheral tissues.

This increased oxygenation then leads to a decrease of pain resulting from diabetic neuropathy.

Conclusion

Diabetic neuropathy can cause debilitating pain, which can affect sleep patterns and quality of life. Current treatments include the use of tricyclic antidepressants, antiarrhythmics, antiepileptics, opioids and topical creams. The application of the non-invasive, non-painful over-the-skin deoxyhemoglobin vasodilator, D’OXYVA, has been widely reported to significantly lower the levels of pain and discomfort caused by this common complication of diabetes.

References

  1. https://www.cdc.gov/diabetes/data/statistics/statistics-report.html
  2. https://www.webmd.com/diabetes/guide/glycated-hemoglobin-test-hba1c
  3. https://doxyva.com/

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HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless over-the-skin microcirculatory solution that has been validated to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

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Disorders of Microcirculation, Prevention and Treatment

Microcirculation[1] involves the smallest branching blood vessels in the body, which are the arterioles, the venules and the capillaries. These tiny blood vessels provide essential perfusion to the tissues of the body and supply oxygen while carrying away toxic metabolic waste products. Disorders of microcirculation can affect all end organs of the body, such as through the cardiovascular system, the central nervous system, peripheral circulation to the lower extremities and blood flow to the eyes and to the kidneys. The following case study involves a patient with multiple disorders of microcirculation that were all improved by application with D’OXYVA[2]

Arnie F was a 64-year-old white male with a long history of uncontrolled type 2 diabetes mellitus for the last 13 years, hypertension, depression, cardiovascular disease and kidney disease.

Due to his uncontrolled diabetes mellitus, Arnie had developed peripheral neuropathy and 2 large non healing ulcers[3] over the malleolar areas on both feet and over the soles of both feet.

These ulcers had never completely healed over a 9-year period.

Arnie also reported severe pain in his legs and calves most nights, with a self-reported score of 7 out of a possible 10 on the visual pain scale.

On physical exam, Arnie had a blood pressure of 140/95 and a body mass index of 26.

He also had diminished pedal pulses on both feet along with 2+ edema of both lower extremities.

After application with D’OXYVA, which is a deoxyhemoglobin transdermal vasodilator, for 5 minutes twice a day for 25 days, Arnie’s previously non-healing foot ulcers were nearly completely healed and he avoided the need for amputation.

In addition, Arnie’s leg and foot pain was eliminated after 4 weeks of D’OXYVA, and his depression lifted without additional medications.

Finally, Arnie’s exertional chest pain, which was due to his cardiovascular disease,[4] was also relieved and he was now able to walk 2 blocks without shortness of breath or chest pain.

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Common Conditions Caused by Impaired Microcirculation

There are a number of common conditions caused by defects in microcirculation. These include the following:

  • Non-healing diabetic foot ulcers
  • Depression
  • Chronic pain from diabetic neuropathy
  • Chronic pain from fibromyalgia
  • Chronic pain from chronic wounds
  • Chronic pain from degenerative arthritis
  • Chronic pain from rheumatoid arthritis
  • Chronic pain from osteoporosis
  • Chronic pain from migraine headaches
  • Chronic lower back pain
  • Cardiovascular diseases such as ischemic heart disease and hypertension
  • Obesity
  • Insulin resistance
  • Type 2 diabetes mellitus
  • Chronic renal failure
  • Peripheral vascular disease
  • Venous insufficiency

Conclusion

Disorders of microcirculation[5] affect many different organs and systems of the body including the cardiovascular system, the peripheral vascular system and the central nervous system. D’OXYVA has been shown to be an effective application in  many conditions such as nonhealing wounds of the lower extremities and depression and in increasing strength and endurance in patients with cardiovascular diseases.

References

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471451/
  2. https://doxyva.com/
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338469/
  4. https://spectrum.diabetesjournals.org/content/21/3/160
  5. https://www.jvascsurg.org/article/S0741-5214(05)00879-7/abstract

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless over-the-skin microcirculatory solution that has been validated to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

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Signs You’re at Risk for Spider Veins

Major risk factors for spider veins, varicose veins

Spider veins are dilated superficial blood vessels that often appear on the surface of the lower extremities or on the face. They are usually caused by damage to the small valves in veins, which causes back-flow, increased pressure and venous dilation.

An example of a patient with spider veins is Helen R., a 38-year-old white female with a history of spider veins behind both knees and thighs bilaterally that developed after pregnancy.

Helen had a medical history of deep venous thromboses in both legs at the age of 35. She also had a history of smoking one pack of cigarettes per day for the past 25 years. Helen had gained 40 pounds during her pregnancy.

To take care of her spider veins, Helen was placed on a regimen with D’OXYVA®,[1]  a transdermal deoxyhemoglobin microcirculation vasodilator. She was given 5-minute applications 5 times per week for 2 weeks, which eliminated all of her spider veins.

How Does D’OXYVA® Eliminate the Appearance of Spider Veins?

D’OXYVA® works to eliminate spider veins by gently delivering a supersaturated mixture of water vapor and ultra-purified carbon dioxide (CO2) with no pressure or force through the surface of the skin. Studies with D’OXYVA have shown that this approach elicits a response from the microcirculation (the smallest blood vessels in the body), which improves and normalizes circulation and oxygenation.

D’OXYVA also works by balancing the effects of the autonomic nervous system (the sympathetic and parasympathetic nervous systems) to achieve a state of homeostasis. Furthermore, it so-called hypoxia inducible factors play a critical role in the exceptional safety and efficacy profile of D’OXYVA.

Major Risk Factors for the Development of Spider Veins

There are a number of risk factors for the development of spider/varicose veins. These include:

  • Gender—Female patients have a much higher risk of developing spider veins[2]than male patients.
  • Genetic history—The majority of patients with spider veins have a close relative with spider veins.
  • Pregnancy—Pregnancy increases the downward pressure on veins in the lower extremities, leading to an increase in spider veins.
  • Weight—Obese patients have an increased body mass index, which puts added strain on the veins of the lower extremities, causing spider veins.
  • Age—With increasing age, the valves in the veins can become weaker, leading to backflow and pooling of blood in the veins, which increases venous pressure and causes spider veins.
  • Birth Control Pills—Patients on birth control pills have a higher risk of developing spider veins than women who are not on birth control pills.
  • Sitting/Standing for Long Periods of Time – Extended periods of sitting or standing without changing positions can lead to pooling of blood in the lower extremities, leading to the development of spider veins.
  • A History of Lower Extremity Blood Clots—Deep venous thromboses (DVTs), which are blood clots in the deep veins of the legs, can lead to damaged valves and resultant spider veins.
  • Hormonal Therapy—Patients on hormone replacement therapy for menopausal symptoms are also at increased risk for developing spider veins.

Ways to Decrease the Risks of Developing Spider Veins

To decrease the risk of developing spider veins,[3] here are some helpful suggestions:

  • Maintain a healthy diet and exercise program to establish a healthy weight.
  • Avoid sitting or standing for more than 30 minutes at a time.
  • Avoid crossing your legs when sitting for long periods of time, as this can decrease circulation.
  • Avoid wearing high heels for long periods of time, as this can reduce blood circulation in the calf muscles.
  • Elevate your feet whenever possible when taking a break from work or extended sitting or standing.

Reference(s)

  1. https://doxyva.com/spider-varicose-veins/
  2. https://www.womenshealth.gov/a-z-topics/varicose-veins-and-spider-veins
  3. https://www.healthline.com/health/how-to-prevent-varicose-veins#outlook
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Defects in Microcirculation and the Effect on Wound Healing: New Non-Invasive Treatments

Defects in Microcirculation and the Effect on Wound Healing: New Non-Invasive Treatments

The effects of defects in and poor functioning of the microcirculation on wound healing, especially in diabetic patients, can be devastating and life changing. As one particular example, Joseph L., a 63-year-old male with a 24-year history of diabetes mellitus, hypertension, elevated cholesterol and arthritis. Joseph had been taking insulin for the past 12 years but his blood sugar levels were still poorly controlled.

On physical exam, Joseph had several very large, oozing and foul smelling deep ulcers located on the dorsum (top) of the left foot. After 8 weeks of intensive therapy utilizing the non-invasive D’OXYVA transdermal deoxyhemoglobin vasodilator, Joseph’s ulcers healed entirely and he avoided amputation of his left foot. Read on to learn more about this new non-invasive wound treatment that helps in wound healing.

What is the microcirculation?

The microcirculation refers to the smallest blood vessels in the body that supply oxygen to the tissues and remove waste products. This includes the arterioles, the venules and the capillaries. When the vessels of the microcirculation become damaged, it leads to decreased blood flow with lower oxygen blood levels and resultant damage to the skin resulting in a wound or ulcer.

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Risk Factors for the Creation of Chronic Wounds

Patients with the following risk factors are at greater risk for non-healing wounds or ulcers (ulcers are the most common type of chronic wounds):

  • A history of decreased blood flow to a specific area (ischemia)
  • A history of uncontrolled diabetes (which leads to poor circulation, nerve damage and breakage of the skin)
  • A history of uncontrolled hypertension (high blood pressure)
  • A history of high cholesterol and atherosclerosis (cholesterol plaques in the arteries)
  • A history of blood clots (thrombosis)

Diabetic Foot Ulcers

Diabetic foot ulcers are a common complication of uncontrolled diabetes mellitus.1 Chronically elevated blood sugar levels damage the microcirculation of the lower extremities, which leads to ischemia and neuropathy (damage to the nerves). Diabetic patients often lose feeling in the feet and so are not aware of friction and pressure, which leads to breaks in the skin. This subsequently leads to open wounds that often do not heal over a 30 day period. These wounds can then become infected, leading to gangrene and eventual amputation.

An Example of a New Non-Invasive Treatment to Enhance Wound Healing

D’OXYVA is a non-invasive transdermal deoxyhemoglobin vasodilator that delivers FDA-approved ultra-purified CO2 molecules which diffuse through the skin leading to increased skin perfusion. In studies of the treatment of diabetic foot ulcers with D’OXYVA, increased diabetic wound healing was observed with wound closure often observed within 5 weeks.

Conclusion

Chronic conditions like uncontrolled diabetes and hypertension can cause damage to the microcirculation, which leads to delayed wound healing. New treatment methods like D’OXYVA deliver transdermal CO2-enhanced oxygen and nutrients to wound areas through the microcirculation. This speeds up wound healing and wound closure and helps avoid devastating complications such as amputations.

Reference(s):

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317316/

HOW D’OXYVA CAN HELP?

In an ongoing multi-year, multi-country, multi-center, randomized clinical trial on patients with diabetic foot ulcers, D’OXYVA has demonstrated speeding up diabetic wound healing and ultimately wound closure to an average of 5 weeks**.

In addition, D’OXYVA eliminated pain and improved quality of life such as sleep, appetite and mood in just a week in 100% of subjects. No adverse events of any kind were reported during, and years after the studies.

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How does transdermal non-invasive CO2 infusion at the thumb cause improved blood circulation and cellular O2 levels in the foot?

"The D’OXYVA device is safe and can be administered at home." - Prof. Judy M. Delp, Professor of Biomedical Sciences, Florida State University (microcirculation)

ABOUT THE AUTHOR

Judy M. Delp Ph.D.

Job Description

Professor of Biomedical Sciences

Education

B.S. Rockhurst University, Kansas City, Missouri

Ph.D. University of Missouri

Memberships

American Physiological Society

American Microcirculatory Society

American Heart Association

Toriyama et al.17 studied the effect of CO2 bathing in 83 limbs with critical ischemia and achieved limb salvage in 83% without surgery. They concluded that peripheral vasodilation from CO2 bathing resulted from an increased parasympathetic and decreased sympathetic activity. In the current study, treatment with transdermal CO2 in a localized area produced a sustained, remote vasodilation, and a lowering of systemic blood pressure.

These findings share some similarity with the hemodynamic changes that occur following an acute bout of exercise, in which both neural and vascular components contribute to a sustained decrease in vascular resistance and blood pressure that persists after cessation of exercise18. In the current study, the period of sustained vasodilation seen in response to transdermal CO2 was heightened in diabetic patients.

Interestingly, in hypertensive individuals, the period of post-exercise hypotension is of greater magnitude and duration as compared to that of normotensive individuals 18, 19. Paradoxically, the current findings in diabetic patients exposed to transdermal CO2 as well as previous findings in hypertensive patients post-exercise, imply that sensitivity to signals that mediate these cardiovascular responses increases in patients with pre-existing cardiovascular dysfunction19.

A sustained decrease in systolic blood pressure occurs post-exercise and here, following application of transdermal CO2, suggesting that neural mechanisms contribute to the observed reduction in systemic vascular resistance. The roles of efferent sympathetic nerve activity18-20, afferent nerve activity from muscle 21-24, and the baroreceptor reflex20, 23 in mediating post-exercise hypotension remain controversial.

Neural mechanism(s) could contribute to changes in skin SPP and systolic blood pressure induced by exposure to transdermal CO2Future studies will need to monitor heart rate, heart rate variability, and sympathetic nerve activity during and after transdermal CO2 in order to more fully assess the role of the autonomic nervous system in mediating the sustained increases in SPP and systolic blood pressure reported in this initial study.

Vascular conductance increases in both active muscle and inactive vascular beds following a bout of dynamic exercise 25, 26, suggesting that circulating factors contribute to this period of sustained systemic vasodilation. Vasodilation occurring independently of neural regulation constitutes more than 50% of the increase in systemic vascular conductance that occurs post-exercise; however, the mechanisms that underlie the post-exercise vasodilation have remained elusive.

Studies that have employed blockade of nitric oxide or evaluation of circulating nitric oxide metabolites have shown that the post-exercise vasodilatory response does not rely on circulating nitric oxide availability27, 28. A recent study by New and colleagues28 indicates that the nadir of post-exercise hypotension coincides with the peak of appearance of lipid hydroperoxides in venous blood, suggesting that reactive oxygen species with known vasodilatory properties29-32 contribute to the exercise-induced decrease in systemic vascular resistance. In the current study, transdermal CO2 was applied to the thumb, and a significant increase in SPP was measured at the toe.

Thus, a similar circulating vasodilatory stimulus may contribute to the remote, sustained vasodilation created by local transdermal application of CO2Further investigations will need to focus on the identification of the mechanisms involved in both the local and remote factors that contribute to the sustained hemodynamic changes produced by exposure of the skin to CO2.

Recently, studies have documented that episodes of brief, non-damaging ischemia occurring in a tissue can induce systemic protection against ischemia-reperfusion injury in a remote organ. This phenomenon, termed remote ischemic conditioning, has been demonstrated to confer protection against ischemic events in the myocardium33-35, brain36, and kidney37, 38.

Although shown to be effective in various clinical and pre-clinical models 34, 35, 38-40, the mechanism(s) of remote protection have not been clearly identified. Both neural and humoral mechanisms have been proposed to contribute to the protection against ischemic damage afforded by remote ischemic conditioning38, 39, 41-43.

Basalay et al.41 have shown that when remote ischemic conditioning is applied before induction of myocardial ischemia, sensory nerves and recruitment of a parasympathetic neural pathway are involved in reduction of infarct size. In contrast, application of remote ischemic conditioning after myocardial ischemia also afforded protection against infarction, but was not altered by vagotomy or peripheral denervation41.

Remote ischemic conditioning has also been demonstrated to improve perfusion of transplanted kidneys, suggesting that remote conditioning confers protection that does not rely on intact neural circuitry38. Recently, Michelsen and colleagues42 have demonstrated that dialysate of human plasma from subjects who underwent either ischemic preconditioning or exercise preconditioning reduced infarct size in rabbit hearts, indicating that release of a humoral factor, possibly acting on opioid receptors, contributes to the cardioprotective effects of ischemic and exercise preconditioning.

Other reports in the literature have also shown evidence of a humoral substances that mediate protection against ischemia when remote ischemic conditioning is applied; however, these substance(s) remain to be identified. Application of transdermal CO2 produces a remote vasodilation that may be mediated through release of a circulating humoral agent.

Future investigations will need to focus on assessment of plasma samples during and following transdermal CO2 application.

This pilot study demonstrated an increase in measures of remote skin microvascular function with D’OXYVA, a simple commercially-available device to deliver transdermal CO2. The effects of the treatment were evident at all periods up to and including the last test period, 240 minutes post-exposure.

Click below to access Prof. Judy Delp’s Presentation on Transdermal Delivery of Carbon Dioxide Boosts Microcirculation.

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HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been clinically tested to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

LEARN MORE ABOUT D’OXYVA

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Men With Erectile Dysfunction May Also Want To See A Heart Doctor

Men With Erectile Dysfunction May Also Want To See A Heart Doctor

Troubles in the bedroom can be a double whammy for older men: Researchers have found that erectile dysfunction ups the risk for heart disease.

Their four-year study concluded that men whose impotence is vascular-related, not emotional, are twice as likely to suffer a heart attack, stroke or sudden cardiac death.

This was true even without other heart risk factors such as high blood pressure, high cholesterol or a history of smoking.

“The magnitude of the effect was surprising to me,” said study author Dr. Michael Blaha.

The findings suggest doctors should aggressively manage other risks such as high blood pressure or high cholesterol in men with erectile dysfunction, said Blaha. He is director of clinical research with the Johns Hopkins Center for the Prevention of Heart Disease in Baltimore.

The link between impotence and heart disease appears to be “a two-way street,” Blaha said, given that men who have had a heart attack appear to face a higher risk for ED.

For this study, the investigators tracked the heart health of about 1,900 men, ages 60 to 78, with and without vascular-related impotence.

Vascular impotence “is at its root a cardiovascular problem,” Blaha said. Unlike impotence related to anxiety or other psychological concerns, vascular ED stems from arterial blockage and insufficient blood flow.

“ED may be a sign of subclinical cardiovascular dysfunction,” said Blaha.

Experts have long observed that impotence is associated with poor cardiovascular health, but it was thought that obesity, high blood pressure and diabetes were some of the reasons why.

This study found that impotence on its own is a significant risk factor.

“In addition, this signal for increased risk is independent of depression and medication usage, said Blaha. That appears to negate theories that depression or its treatment might explain any link between impotence and heart disease.

Study participants were enrolled in the Multi-Ethnic Study of Atherosclerosis, conducted in several U.S. cities. Over four years, 115 men had a serious heart problem, such as heart attack, stroke or cardiac arrest.

The investigators determined that just over 6 percent of men with ED experienced such an event, compared with just under 3 percent of sexually healthy men.

So what should an impotent man do?

Blaha suggested a visit to a doctor or a preventive cardiologist. “In some cases, these men need screening for early cardiovascular disease,” he said.

“Many men at risk for cardiovascular disease seek medical care not for management of risk factors, but for their ED. Our study is an alert that such patients need a thorough cardiovascular evaluation in addition to their treatment for ED,” Blaha said

Dr. Richard Becker, an American Heart Association spokesman, said the study results need confirmation. Still, the strength of the findings were “striking,” he said.

“Health care providers should consider including ED as a component of assessing cardiovascular risk among middle-aged men,” said Becker, a professor of medicine at the University of Cincinnati who was not involved with the study.

“While there are effective treatments for ED, one must never overlook an opportunity to ask a simple question: ‘Why?’ In addition, men should be aware of the potential implications of ED and inform their provider,” Becker said.

The findings were published June 11 in Circulation.

Source(s): https://www.cbsnews.com/news/men-with-erectile-dysfunction-may-also-want-to-see-a-heart-doctor/