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The Important Role Oxygen Plays in Cancer Treatment

One of the most important things to remember about cancer is it is NOT a chemotherapy disease, it is NOT a radiation disease and it is not a Vitamin C disease. Cancer is actually a metabolic dysfunction tied to genetic mutations, and the first step in fighting it is on the metabolic level. This approach is what has helped our team achieve a unique and successful treatment strategy. Let’s learn how oxygen plays a role in the development and treatment of cancer.

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Every cancer has a trigger: infections, chemical toxins or heavy metal toxins are a few of the main ones. Early changes are seen through metabolic shifts that ultimately cause mutation, continually pushing genetic changes, growth and spread throughout the life of the cancer. Let’s take a look at how changes in oxygen metabolism are some of the first metabolic signs of difficult cancers.

Oxygen’s Important Role In Cell Metabolism and Cancer Growth

Cancer is a very difficult to understand disease and there are many misconceptions associated with it. But one of the main keys of understanding, treating and ultimately winning the raging war against cancer is none other than oxygen. Eighth on the periodic table, oxygen is responsible for the breathing of cells and are essential role in providing energy.[1] However, cancerous, mutated cells thrive in anaerobic, or oxygen-lacking environments.

When growing, cancer cells show a change where they have lower levels of oxygen. This may stem from dysfunctions in the cell’s mitochondria (known as cellular “factories” that play a major role in cell respiration). If these issues go unchecked, it leads to further complications and malfunctions in apoptosis (programmed cell death). You may remember from biology class, mitochondria have two main functions: energy creation and policing uncontrolled division of cells.

Nobel Prize winner Dr. Otto Warburg famously hypothesized “…the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar,” meaning, cancer is caused by a lack of oxygen. Today’s modern cancer cell biology has shown he was on the right track as mitochondrial health and shifting to a more oxygen-rich environment may protect healthy cells and further neuter cancer cells.

Furthermore, malignant, rapidly growing tumor cells typically have glycolytic rates up to 200 times higher than those of their normal tissues of origin. This means cancer has a much higher need for sugar than normal cells; this has been proven by the abnormally high level of insulin receptors found on all cancer cells. Because cancer cells favor the lack of oxygen, they shift to glycolytic pathways; put simply they use glucose as their source of energy. Cancer cells average about 16 times more insulin receptor sites than normal cells.

It’s important to realize that the genetics of a cancer in its early stages and its late stages are completely different. This is what makes late-stage cancer so complex and difficult to treat – you’re essentially trying to overcome these numerous advanced metabolic changes. Let’s look at some of the gene pathways that make this issue even more compounded.

Angiogenesis is a normal, healthy cell process through which new blood vessels form from pre-existing vessels. However, it’s also the fuse which sets off unchecked growth, turning benign tumors into malignant steamrollers. It’s also what transitions the metabolism of the cancer, making it that much harder to kill.

Hypoxia is when a portion of the body doesn’t have adequate oxygen supply. Hypoxia-inducible factor 1-alpha, (HIF-1-alpha,) is a protein that is encoded by the HIF1A gene, playing an essential role in cellular and systemic responses to hypoxia. Cancer cells use this protein to grow their blood supply and spread.

According to a study by the Liver Cancer Institute at Zhongshan Hospital and Shanghai Medical School in Shanghai, “HIF-1alpha in HCC [hepatocellular carcinoma, the most common form of liver cancer] plays an important role in predicting patient outcome. It may influence HCC biological behaviors and affect the tumor inflammation, angiogenesis and act in concert with the oncogene MYC [a gene found in many cancers] . Attaching importance to HIF-1alpha in HCC may improve the prognostic and therapeutic technique.” [2]

Epidermal Growth Factor Receptor (EGFR) is normally used to tell cells to grow. It is found in all cancer cells. However, EGFR over-expression has been linked to numerous cancers, such as lung, prostate, colon, breast, anal and others.

This receptor is also associated with increased chemotherapy resistance, leading to tumors that are untreatable. Additionally, EGFR is linked to insulin, making it the metabolic gasoline that fuels changes and growth in the cell.

This also links back to HIF-1 alpha. According to a study by the Department of Pathology at the VU University Medical Centre in Amsterdam, “In invasive breast cancer, HIF-1alpha is associated with angiogenesis, and expression of growth factors [including] the receptor EGFR. Thus, agents targeting HIF-1 may combine different pathways of inhibiting breast cancer growth, including angiogenesis and growth factors.” 

M2-PK (also known as PKM2) is an enzyme that is important in tumor metabolism, discovered in 2010 by Harvard Medical School. Tumor M2-PK helps cancer cells shift to greater glycolytic pathways. It is only found in cancer cells and not in normal healthy cells, making M2-PK an excellent marker for monitoring excelled growth or tracking improvement in treatment, depending if levels are high or low.

Chemotherapy and radiation therapy both rely on Reactive Oxygen Species (ROS) to work, augmenting ROS stress. ROS are essential toxic substances like hydrogen peroxide and others that can cause damage to cells in high concentrations. ROS are natural byproducts of the metabolism of oxygen, however, more resistant cancers actually produce their own antioxidants to fight these toxic substances.

Earlier stage cancers do not appear to have the same defense mechanisms that are found in more resistant later stage cancers. This explains why chemotherapy and radiation therapy may not work in late-stage cancers. The answer may involve actually increasing ROS levels so therapy can kill cancer cells once again – this is the therapeutic aim of oxidative medicine, giving high doses of antioxidants and creating ROS instead of destroying it. Therefore, the dosing and delivery change the entire mechanism of action of integrative treatments.

In this form of ROS, oxygen is what actually allows chemotherapy and radiation to work. Several types of DNA damage are caused by ROS-related oxidation. That is the goal of effective cancer treatment, to not only kill cancer cells but their genetics as well. In many cases, when oxidative therapy is combined with correctly-tested chemotherapy you can improve overall treatment for patients.

Everyone’s metabolism is different and therefore, every cancer patient’s tumor’s metabolism is different. By using the oxygen metabolism and other signaling pathways like EGFR and M2-PK, doctors can find the specific metabolism and make the strongest push in their favor. This is one major focus of our group, as we see cancer for what it is: a metabolic dysfunction pushing for constant genetic mutations, which aids its spread.

The best part about these treatments is they are helpful for most, if not all cancers. If you have questions about your specific cancer. Keep in mind, knowing this is only a small part of the battle and only one of several unique and successful strategies we’ve used that gives our patients an important advantage. If you have any questions about your cancer, or would like to know more about how integrative medicine might help, please contact us today.

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Why Use D'OXYVA?

The link between oxygen and cancer is clear. In fact, an underlying cause of cancer is usually low cellular oxygenation levels.

In 1931 Dr. Warburg won his first Nobel Prize for proving cancer is caused by a lack of oxygen respiration in cells. He stated in an article titled “The Prime Cause and Prevention of Cancer… the cause of cancer is no longer a mystery, we know it occurs whenever any cell is denied 60% of its oxygen requirements…”

D’OXYVA® (deoxyhemoglobin vasodilator) is an over-the-counter (OTC) device, which is the first biotech solution of its kind backed by widely-established groundbreaking Nobel Prize-winning science validated to significantly improve macro-, and micro-circulation of blood flow and certain nerve activities in the body such as the autonomic nervous system, which together are widely reported to form an effective solution option for many of the most severe and widespread health conditions.

FDA-approved CO2 drug mixtures manufactured in FDA-audited pharmaceutical factories are approved by the U.S. FDA as oxygen therapies and Circularity markets a prescription drug version via licensed physicians of its successful D’OXYVA OTC/wellness product line.

Reduce unwanted doctor visits, recommended and ranked top by experts!

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Microcirculation: Exploring and understanding the unknown

cancer

Everything is in the microcirculation. According to Dr. Ricardo Quintos II, most medical problems, particularly serious ones like stroke, kidney failure or heart attack, can trace its roots to circulation.

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Medical practitioners need to focus on, and have a better understanding of, the blood flow through the smallest vessels in the circulatory system, or microcirculation, he said. Just like vascular surgery, of which Dr Quintos is a pioneer of in the Philippines, he is now setting his sights on looking at the unseen.

“One of the reasons that made me go into vascular is the realization that all these organs are served by the vascular tree,” Quintos told MIMS in an interview.

The vascular tree is made up of arteries, arterioles, capillaries, venules and veins. All together, these constitute the complex system that is at the heart of circulation – capillary exchange.

To illustrate the importance of microcirculation, Quintos used cancer as an example.

One reason there is cancer is because of a disordered growth in the vascular tree supplying cancer cells with too much blood and nutrients, he explained.

Using chemotherapy agents is not the answer to treat the cancer because not only will it kill the cancerous cells, but also the normal ones. The better treatment course is to address the vascular problem. – Dr. Ricardo Quintos

“What you do is just starve the cancer cells. You give antiandrogenic substances so that vascular tree will just shrink. And once that happens, they will have no more blood and will just die.”

A second example is how to treat vascular problems when a patient has a heart attack. Instead of doing a bypass to allow more blood to go to the heart, Quintos recommended making the heart “grow its own arteries.” More specifically, to give androgenic factors to make the arteries grow its own bypasses, which is not only less risky but also more natural.

“And that is what we mean by looking into the microcirculation,” Quintos stressed.

The vascular surgeon said they have put up their own microcirculatory laboratory and undertaken research on microcirculation.

“All of these vascular procedures will not work if your microcirculation is not working,” he explained.

He said a heart attack is not the result of blockage in the arteries of the heart, but rather the microcirculation of the heart is not working very well, because the cells there are poor. The brain, Quintos pointed out, stops working not due to poor circulation but because microcirculation to the brain breaks down.

Having made great inroads in the field of vascular surgery, Quintos now sees microcirculation as the future in medical treatment.

“We have to look into what we cannot see before. And the thing we cannot see in the vascular world is microcirculation,” he said, adding, “Ultimately, it’s all for the patient.”

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Why Use D'OXYVA?

The link between oxygen and cancer is clear. In fact, an underlying cause of cancer is usually low cellular oxygenation levels.

In 1931 Dr. Warburg won his first Nobel Prize for proving cancer is caused by a lack of oxygen respiration in cells. He stated in an article titled “The Prime Cause and Prevention of Cancer… the cause of cancer is no longer a mystery, we know it occurs whenever any cell is denied 60% of its oxygen requirements…”

D’OXYVA® (deoxyhemoglobin vasodilator) is an over-the-counter (OTC) device, which is the first biotech solution of its kind backed by widely-established groundbreaking Nobel Prize-winning science validated to significantly improve macro-, and micro-circulation of blood flow and certain nerve activities in the body such as the autonomic nervous system, which together are widely reported to form an effective solution option for many of the most severe and widespread health conditions.

Reduce unwanted doctor visits, recommended and ranked top by experts!

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Did you know when used in a regimen, D`OXYVA users have reported a number of health and beauty benefits?

doxyva benefits

OPTIMIZE BLOOD CIRCULATION FOR A WIDE VARIETY OF SIGNIFICANT OUTCOMES

D’OXYVA® (deoxyhemoglobin vasodilator) in various clinical trials has validated leading independent research results and demonstrated above-average results in improving a host of physiological functions at the same time.

People using D’OXYVA® have recorded significant improvements in cardiovascular activity leading to much improved physical activity. As part of a healthy lifestyle, D’OXYVA may help significantly reduce the risk of high blood pressure, hypertension, cholesterol, and diabetes in just two or three months, with an average use of 5 minutes a day and 5 times a week.

Poor circulation is a gateway for a litany of ailments: slow healing, depression, poor complexion, sores, slow metabolism, and more.

D’OXYVA significantly improves sustained oxygen-rich microcirculatory blood flow locally and throughout the body. Its patented method of fully non-invasive, painless, and harmless transdermal delivery is unique only to D’OXYVA.

When used daily, D’OXYVA users have reported a number of health and beauty benefits, including but not limited to:

  • Relief from symptoms of microvascular complications
  • Significantly increased cardiac function, physical fitness, endurance and strength, muscle size, body tone, faster recovery from sports injuries and surgical trauma
  • Improved self-esteem via promoting healthy and radiant skin, complexion, dry skin relief, and acne reduction
  • Significant reduction in downtime from other skin treatments and cosmetic procedures when used in combination, reduction in the appearance of scars, cellulite, fat, spider veins and stretch marks
  • Promoting and maintaining a healthy weight, improving general mobility, deeper, more restful sleep
  • Significant improvement of mental acuity; concentration, problem solving, multitasking, eye-hand coordination, heightened stamina, energy, and focus while managing stress
  • Improved vitals across the board during checkups with zero adverse event reports after years of regular use by people with various health, demographic, and ethnic backgrounds

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been clinically tested to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

Reduce unwanted doctor visits, recommended and ranked top by experts!

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Did you know that Low Oxygen Levels Breed Cancer Increasing Cellular Oxygen Levels Kills Cancerous Cells?

D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.

The link between oxygen and cancer is clear. In fact, an underlying cause of cancer is usually low cellular oxygenation levels.

In newly formed cells, low levels of oxygen damage respiration enzymes so that the cells cannot produce energy using oxygen. These cells can then turn cancerous because they don’t make enough energy to function normally in the body.

In 1931 Dr. Warburg won his first Nobel Prize for proving cancer is caused by a lack of oxygen respiration in cells. He stated in an article titled “The Prime Cause and Prevention of Cancer… the cause of cancer is no longer a mystery, we know it occurs whenever any cell is denied 60% of its oxygen requirements…”

“Cancer, above all other diseases, has countless secondary causes. But, even for cancer, there is only one primary cause. Summarized in a few words, the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar. All normal body cells meet their energy needs by respiration of oxygen, whereas cancer cells meet their energy needs in great part by fermentation. All normal body cells are thus obligate aerobes, whereas all cancer cells are partial anaerobes.”

Poor oxygenation comes from a buildup of carcinogens and other toxins within and around cells, which blocks and then damages the cellular oxygen respiration mechanism. Clumping up of red blood cells slows down the bloodstream, and restricts flow into capillaries. This also causes poor oxygenation. Even lack of the proper building blocks for cell walls, Omega 3 essential fatty acids, restricts oxygen exchange.

Warburg and other scientists found that the respiratory enzymes in cells, which make energy aerobically using oxygen, die when cellular oxygen levels drop below 65%.

When the mitochondrial enzymes get destroyed, they’re host cell can no longer produce all its energy using oxygen. So, if the cell is to live, it must, to some degree, ferment sugar to produce energy. For a short period of time, like when running a race, this anaerobic fermentation of sugar is okay. Your legs build up lactic acid from this fermentation process and burn, and you stop running. Then your cells recover and produce energy using oxygen. However the problem comes when your cells cannot produce energy using oxygen because of this damage to the respiratory enzymes. Then they must produce energy primarily by fermentation most of the time. This is what can cause a cell to turn cancerous.

According to Warburg, cells that produce energy by fermenting sugars may turn cancerous. Warburg’s contention is this…

The cells that cannot produce energy aerobically, cannot produce enough energy to maintain their ability to function properly. So they lose their ability to do whatever they need to do in the body.

Fermentation allows these cells to survive, but they can no longer perform any functions in the body or communicate effectively with the body. Consequently, these cells can only multiply and grow. And may become cancerous. Or perhaps it would be more accurate to say, they degrade into cancer cells that no longer serve your body, but live to survive…

Decades ago, two researchers at the National Cancer Institute, Dean Burn and Mark Woods, (Dean translated some of Warburg’s speeches) conducted a series of experiments where they measured the fermentation rate of cancers that grew at different speeds. What they found supported Dr. Warburg’s theory.

The cancers with the highest growth rates had the highest fermentation rates. The slower a cancer grew, the less it used fermentation to produce energy.

Naturally Warburg’s contention about oxygen and cancer was challenged and tested by other scientists.

Some researchers claimed his theory was not valid after they had measured a particularly slow growing cancer, and found no fermentation at all. And if cancer could grow with no fermentation, then fermentation, or lack of oxygen respiration, was not the cause of cancer. Dean Burn and Mark Woods checked those results.

Using more sophisticated equipment, they determined that the equipment these researchers used to measure fermentation levels was not accurate enough to detect fermentation at low levels. Their testing, using newer and more accurate equipment, showed that even in those very slow growing cancer cells, fermentation was still taking place, at very low levels.

Pietro Gullino, also at the National Cancer Institute, devised a test which showed that this slow growing cancer always produced fermentation lactic acid. Silvio Fiala, a biochemist from the University of Southern California, also confirmed that this slow growing cancer produced lactic acid, and that it’s oxygen respiration was reduced.

Further research into Warburg’s theory showed that when oxygen levels were turned down, cells began to produce energy anaerobically. They ultimately became cancerous when levels went low enough. It took a reduction of 35% in oxygen levels for this to happen.

J. B. Kizer, a biochemist and physicist at Gungnir Research in Portsmith, Ohio explains, “Since Warburg’s discovery, this difference in respiration has remained the most fundamental (and some say, only) physiological difference consistently found between normal and cancer cells. Using cell culture studies, I decided to examine the differential responses of normal and cancer cells to changes in the oxygen environment.

“The results that I found were rather remarkable. I found that… “High 02 tensions were lethal to cancer tissue, 95 percent being very toxic, whereas in general, normal tissues were not harmed by high oxygen tensions. Indeed, some normal tissues were found to require high 02 tensions. It does seem to demonstrate the possibility that if the 02 tensions in cancer tissues can be elevated, then the cancer tissue may be able to be killed selectively, as it seems that the cancer cells are incapable of handling the 02 in a high 02 environment.”

Low oxygen levels in cells may be a fundamental cause of cancer. There are several reasons cells become poorly oxygenated. An overload of toxins clogging up the cells, poor quality cell walls that don’t allow nutrients into the cells, the lack of nutrients needed for respiration, poor circulation and perhaps even low levels of oxygen in the air we breathe.

Cancer cells produce excess lactic acid as they ferment energy. Lactic acid is toxic, and tends to prevent the transport of oxygen into neighboring normal cells. Over time as these cells replicate, the cancer may spread if not destroyed by the immune system.

There is more to this picture than Otto Warburg understood. It turns out that approximately 85% of cancer cells use this glucose fermentation. Other cancer cells do burn oxygen for fuel. And these cells have a very interesting interaction with the cells using glucose fermentation.

Over the last few years researchers have identified a more sophisticated and accurate description of cancer cell metabolism. It is true that a majority of cells fit into this model of burning glucose to produce energy.

The Latest Research Shows…

that many cancer cells could be burning oxygen for energy, which is vastly more efficient at producing energy, but they aren’t. Researchers pieced together the key to this puzzle. It is very interesting.

Cancer cells don’t need a lot of energy to function, and there is plenty of energy sources available to them. What they do need is a large supply of nutrients necessary to grow and proliferate. Burning oxygen produces a lot of energy, and not much in the way of nutrients to fuel growth. Burning glucose produces little energy, but a lot of nutrients to fuel growth and proliferation.

So it may be that the fastest growing cancer cells utilize glucose fermentation to produce energy because it produces so much more of what they need, nutrients that enable them to grow fast and proliferate more rapidly.

This makes sense. Decades ago, Dean Burns and Mark Woods found that the fastest growing cancer cells had the most glucose fermentation, and the slowest growing cancer cells had the least amount of glucose fermentation.

In addition, over the past few years researchers have noted that some cancer cells burn lactase (lactic acid) and even fat ketones as additional energy sources. Lactic acid is readily available in tumors as most of the cancer cells are burning glucose for energy and producing lactic acid as a byproduct of that process.

They pump out the lactic acid to get rid of it so that it doesn’t overwhelm and destroy them. Other cancer cells in the tumor that are producing energy primarily with oxygen and less with glucose, uptake this lactase, according to researchers, and metabolize it for energy. By doing so, they use less glucose which enables glucose dependent cancer cells to have more to consume.

In order to create more nutrients as a byproduct of cell metabolism, cancer cells also metabolize glutamine. It is also not an efficient source of energy to run the cell, but it supplies valuable nutrients needed by the cancer cells to grow and proliferate.

Shutting Down Cancer Cell Metabolism

Clearly, the key to fighting cancer is shut down as much of the metabolic processes as possible in cancer cells. Stopping both their production of energy, and the more limiting factor, their processing and production of nutrients needed to support the growth of cancer cells and their rapid replication.

Two elixirs mentioned elsewhere in this report help with this. The Pentose Phosphate Pathway Elixir, mentioned in the Foundations of Cancer section, shuts down the primary glucose metabolizing pathways in cancer cells. Glutam, mentioned in the pH and Cancer section reduces the amount of glutamine getting into cancer cells, and inhibits its metabolism.

But more can be done to inhibit the various pathways in cancer cells that produce energy and nutrients. To shut down these pathways, use the…

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HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been clinically tested to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

Reduce unwanted doctor visits, recommended and ranked top by experts!