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Women’s blood vessels age faster than men’s: Study

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New research shows for the first time that women’s blood vessels, both large and small arteries, age at a faster rate than men’s.

The findings, published Wednesday in JAMA Cardiology, challenge the long-held belief that vascular disease and cardiovascular risk in women lags behind men by up to 20 years, concluding that certain vascular changes in women actually develop earlier and progress faster in women compared to men.

“We were inspired to take a much closer look at blood pressure trajectories over the life course in women compared to men because, at the end of the day, the vast majority of cardiovascular disease processes tend to start with blood pressure elevation as a major driving risk factor,” said Dr. Susan Cheng, director of public health research at the Smidt Heart Institute at the Cedars-Sinai Medical Center in Los Angeles, and senior author on the study.

The study looked at nearly 145,000 blood pressure measurements from more than 32,000 people, ranging in age from 5 to 98, over the course of four decades.

Researchers found that blood pressure started increasing in women as early as 30, and continued to rise higher than blood pressure in men throughout the women’s life span.

“Our findings suggest that all the ways by which we think about and aim to prevent or treat high blood pressure likely needs to be more tailored, for women,” Cheng said.

One of the reasons Goldberg, who was not involved in the study, cited for patients not taking their blood pressure medications is that people stop taking them if their blood pressure improves. Treating blood pressure is not like treating a pneumonia or cough, patients must continue to take blood pressure medication for them to be effective.

“We need to be more vigilant, because when high blood pressure is treated it is a way of preventing other diseases, like stroke, heart attacks and heart failure,” Goldberg said.

Dr. Manavjeet Sidhu, MD, MBA, is a chief resident physician in emergency medicine and contributor to the ABC News Medical Unit.

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been clinically tested to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

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D’OXYVA® improves dermal microcirculation and promotes wound healing in the diabetic foot

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Published in PRWeb

Prof. Puruhito and colleagues have released the results of three observational trials showing that D’OXYVA® (Circularity Healthcare LLC), a deoxyhemoglobin vasodilator, improves vasodilation in the treatment of diabetic foot ulcers (DFUs), boosts dermal microcirculation, and helps in the healing process of DFUs.

D’OXYVA® is a validated circulatory and nerve stimulant. The system was used by Prof. Puruhito for CO2 transdermal delivery, which has been shown to produce higher oxygen unloading by hemoglobin, thereby increasing oxygen-rich blood flow in the local microcirculatory system1. This improved dermal microcirculation leads, in turn, to enhanced wound healing2.

The American Diabetes Association standards of care for DFUs refer to microvascular complications and their treatment via improvements in microcirculation; therefore, Prof. Puruhito’s team set out to test CO2 transdermal delivery via D’OXYVA® in their patients. They have been gathering data since 2015, which led to the following results.

During the course of a 5-day treatment, O2 saturation increased in patients treated with transdermal CO2 in comparison to controls (15 patients/group)3 over the whole measurement range (up to 120 minutes post application). Moreover, a consistent heart rate decrease was found in patients undergoing transdermal CO2 treatment. Furthermore, the perfusion index (PI) showed an upwards tendency in the treatment group, whereas it remained stable for untreated controls. See figure 1.

diabetic wound

Figure 1: Changes observed after a 5-day transdermal CO2 treatment with D’OXYVA®. H1-H5: pre-treatment, 10, 30, 60, 90, and 120 minutes after; blue trace: control, orange trace: treatment. (A) Changes in O2 saturation (B) Decrease in heart rate due to treatment (C) Masimo® measurements of PI.

In light of these results, Prof. Puruhito’s team performed extra measurements of transcutaneous carbon dioxide (TcPCO2), O2 saturation, and PI in the 15 patients treated with D’OXYVA® for transdermal CO2 delivery3–5. This data show that the oxygen saturation reached almost 100% in some patients, whereas the TcPCO2 remained relatively stable throughout the treatment time (120 minutes). For more detailed information, see figure 2.

Figure 2: Transcutaneous CO2 pressure (TcPCO2), O2 saturation, and PI assessment in the 15 patients subjected to transdermal CO2. (A) SENTEC TcPCO2 measurements for all patients at various time points after D’OXYVA® application (pre-treatment, 5, 60, 90, and 120 minutes after) (B) O2 saturation (C) PI.

Finally, Prof. Puruhito’s team demonstrated the positive effects of transdermal CO2 delivery via D’OXYVA® on the healing of DFUs5 (fig. 3), proving the clinical potential of this intervention to improve the quality of life of people suffering from this common complication of diabetes.

Figure 3 Wound healing after 5-day treatment with transdermal CO2 delivery via D’OXYVA® in cases of DFU Wagner-1 and Wagner-2

In conclusion, the use of a D’OXYVA® device for transdermal CO2 delivery improves the outcomes of DFUs by enhancing dermal microcirculation and increasing perfusion rates and tissue oxygenation, therefore assisting in the healing process of the ulcers typical of diabetes neuropathy.

ABOUT PROF. ITO PURUHITO

Ito Puruhito, MD is professor in the Department of Thoracic and Cardiovascular Surgery at Dr. Soetomo General Hospital as well as a senior lecturer in the Faculty of Medicine at Universitas Airlangga (Indonesia). From 2001 to 2016, he was the rector of the aforementioned university. Prof. Puruhito finished his medicine studies at Universitas Airlangga in 1967, and in 1972 he received a doctorate degree, graduating cum laude from Frederich-Alexander University (Erlangen-Nürnberg, Germany). In his native country, he developed the Department of Thoracic-Cardiovascular Surgery at his former university, Universitas Airlangga, Surabaya. In 1978, he co-founded the Indonesian Association of Thoracic, Cardiac and Vascular Surgery. Prof. Puruhito has authored numerous indexed research articles in Scopus, ISI-Thompson or PUBMED, and scientific presentations and written several books in Indonesian, English, and German. He acted as reviewer for peer-reviewed journals such as Medical Tribune, Annals of Thoracic and Cardiovascular Surgery, Asian Annals of Surgery, Medicinus, and many more Indonesian medical-surgical journals. Currently, apart from lecturing, Prof. Puruhito actively researches stem cells, cardiovascular medicine, and surgery at the Institute of Tropical Disease as well as some work in microcirculation. Further, he acts as coordinator of research affairs at the Department of TCV-Surgery at Dr. Soetomo General Hospital Surabaya. Since 2014, he has been the chairman of the Council of Research in the Ministry of Research Technology and Higher Education of the Republic of Indonesia.

ABOUT D’OXYVA

D’OXYVA® (deoxyhemoglobin vasodilator) is a novel, clinically validated blood flow and nerve stimulant for people suffering from neuropathy. In various clinical trials, D’OXYVA® has validated leading independent research results and demonstrated above-average results in improving a host of physiological functions.

Subjects suffering from high blood sugar have reported neuropathy pain relief minutes after D’OXYVA® was administered and long-term blood sugar level improvements after just a few weeks.

Rapid and gentle skin delivery (over-the-skin) with the D’OXYVA® lightweight, handheld device has prompted improvements in blood microcirculation or PI by 33%* on average in all participants. Lasting results have been measured at 5-60 minutes and up to 4 hours after a single 5-minute D’OXYVA® delivery on the skin surface without reduction in PI levels.6

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Fibromyalgia and Microcirculation: What Fibro Patients Need To Know

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If you’ve been diagnosed with fibromyalgia, you know how debilitating the disease’s widespread nerve pain can be to your body. New research shows that microcirculation problems may be among the causes of fibro nerve pain. The concept of microcirculation—the circulation of blood in your body’s smallest blood vessels—may be a key to unlocking the mysteries of fibromyalgia. 

The Latest Research on Microcirculation and Fibromyalgia

As more patients are diagnosed with fibromyalgia each year, research on the disease’s causes and potential treatments are increasing rapidly. A study was done on exactly how blood circulates near tender points in the body in fibromyalgia patients. Circulation was found to be poor near tender points, leading researchers to believe that microcirculation near the surface of the skin is at play when it comes to fibromyalgia pain.

Many people who have been diagnosed with fibromyalgia find that it’s harder to exercise than it was before they began experiencing fibromyalgia symptoms. Studies have shown that microcirculation problems can contribute to exercise intolerance and muscular fatigue in fibromyalgia patients. Although exercise has been shown to help with fibromyalgia symptoms, it can be hard to use movement as an effective treatment when it can also lead to painful flare-ups. This can be disheartening for fibro patients who are trying their best to manage their stress and symptoms through exercise. 

Improving Microcirculation in Fibromyalgia Patients

If you think some of your fibromyalgia symptoms may be related to microcirculation problems, you’re not alone. Many fibro patients are finding that improving microcirculation relieves some of their fibro symptoms. Let’s take a look at some of the options for improving microcirculation: 

  • Exercise – As stated above, exercise can be a great way to get the blood moving and improve microcirculation. However, many fibro patients find that they need to experience symptom relief before they feel well enough to exercise. 
  • Heat therapy – Spending time in a sauna or hot tub or using a heating pad can get your blood flowing directly beneath the skin. Although this is a short-term solution, it can provide relief to people who need assistance with microcirculation. 
  • D’OXYVA – A fairly new innovation in the world of microcirculation, D’OXYVA is a transdermal delivery application that significantly improve microcirculation, with validated results to give relief from pain to patients who need it most and are unable to get help with microcirculation through exercise. Most fibromyalgia patients find that they achieve significant pain relief after using D’OXYVA for 2-7 days. 

If you suffer from fibromyalgia, you’re not alone. Help is available. Using a combination of exercise, heat therapy, and D’OXYVA may give you the relief you’re looking for. 

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been validated to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

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Improving Microcirculation for Weight Reduction in Obesity

weight loss obesity

Obesity, by definition, is a Body Mass Index (BMI) of 30 kg per square meter or greater. The prevalence of obesity has increased and is now thought to affect more than one third of the adult population.[1] Recent studies have shown that obesity has an adverse effect on microcirculation and is an important risk factor for the development of many health problems, such as metabolic syndrome (insulin resistance, elevated lipid levels, high blood pressure and increased abdominal girth), ischemic heart disease, heart failure, and other cardiovascular diseases.[2] The following case demonstrates how improving microcirculation can help with weight reduction in obese patients.

Brenda V was a 39-year-old white female patient with severe obesity and a BMI of 52.4 kilograms per square meter.

Brenda’s past medical history was significant because it incuded a history of morbid obesity, high cholesterol, high blood pressure, diabetes mellitus, gout, and depression.

She revealed that she could only walk for one block without severe shortness of breath and had to sleep on 2 pillows at night.

On physical examination, her weight was 340 pounds, and her height was 5 feet, 1 inch.

Her blood pressure was 180/105, and her cardiovascular exam revealed severe pitting edema of both legs.

Brenda’s abdomen was distended and morbidly obese with decreased bowel sounds.

Her laboratory exam showed a hemoglobin A1C level of 12.5% (normal is less than 5.7%) and a triglyceride level of 600 mg/dl (normal is less than 150 mg/dl).

Brenda was put on a regimen of diet, increased exercise, and the use of the peripheral deoxyhemoglobin vasodilator D’OXYVA[3] for 5 minutes per day, 5 times a week, for a 3 month period.

After this treatment she had the following improvements:

  • Increased physical activity
  • Decreased blood sugar levels
  • Decreased blood pressure
  • Decreased triglyceride levels
  • Decreased HgbA1C levels
  • Increased cardiac function
  • Increased endurance
  • Increased physical fitness
  • Decreased depression
  • Massively decreased weight
  • Increased mobility

      BUY D’OXYVA

How Does Obesity Affect Microcirculation?

Microcirculation[4] refers to the body’s smallest branching blood vessels (arterioles, venules, and capillaries with internal diameters less than 100 microns) that supply oxygen to and remove wastes products from the body’s tissues.

Microcirculation responds to changes in metabolic demands or sympathetic nervous system activation by either expanding or contracting to increase or decrease perfusion levels.

Early in the course of obesity, dysfunctional changes begin to appear in microcirculatory endothelial lining cells”.

These changes are caused by oxidative stress and inflammation of the microcirculation[5] and are now thought to lead to both insulin resistance and hypertension.

Conclusion

Obesity has been found to lead to microcirculatory dysfunction, which causes severe health problems, such as metabolic syndrome, diabetes mellitus and various cardiovascular diseases. Reducing obesity through a program of strict dietary control, increased exercise and the use of D’OXYVA to enhance microcirculation can significantly improve general health and reduce the risk of potentially lethal health complications.

      BUY D’OXYVA

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been validated to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

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Innovative Collaboration: The Cutting Edge of Medicine Goes “Behind The Scenes”

LOS ANGELES (PRWEB) DECEMBER 11, 2019

Circularity is partnering with Telly Award-Winning “Behind the Scenes” to provide regular, ongoing, high-quality content from leading experts in a variety of fields with an initial focus on microcirculation science, regenerative medicine, and advanced wound healing and related symptoms. The show reaches 60 million households domestically.

“Behind The Scenes with Host Laurence Fishburne” is a public television icon that has won numerous awards and delivers precision idea-telling at its best. Circularity is an innovative healthcare organization that is health-bent on their trademarked slogan: “Improving Lives by Improving Blood Flow.” Their coming together to bring forward the ideas of modern health science on a stellar entertainment platform can only make for riveting content going forward. Viewers will find themselves in a win-win situation.

Watching informative content via this stylized venue will leave viewers feeling quite satisfied with their television watching experience. It is time well spent and information precisely delivered.

A Little More About Circularity

Circularity is concerned with bringing the very best in healthcare innovation to the public. In so doing, they have manufactured a product called D’OXYVA. This product has a two-pronged approach to health. First, it can be quite effective in reducing the debilitative effects of many of the diseases that are affecting the world today, such as COPD, diabetes, and cardiovascular illnesses. Secondly, Circularity’s D’OXYVA can be used in a preventative capacity to improve microcirculation. The concept of microcirculation has far-reaching implications in neurology, oncology, endocrinology, cardiovascular health, respiratory health, dermatology, diabetic wound healing or diabetic wound care and other major fields.

What “Behind The Scenes with Host Laurence Fishburne” Will Bring to the Table

Behind The Scenes has been an innovator in bringing information to the forefront in the public television space. The award-winning series features segments on the newest technologies, as well as fresh takes on existing entities, phenomenon, and natural occurrences. The show’s website boasts that the television series “highlights the evolution of education, medicine, science, technology and industry through inspiring stories.”

Aside from the Emmy-winning and Academy Award nominated actor Lawrence Fishburne as host, the program has an award-winning creative development team. Viewers walk away with a rich knowledge of the subject. Viewers may have known about this subject their whole lives, or it may be about something completely new. Viewers learn an evolving aspect of the topic which keeps the perspective fresh.

The dawning of a new age has appeared with this collaboration. Individuals who want to know more about what the health science field is bringing into our hospitals and doctors’ offices will not be disappointed. In today’s world, it is imperative that we are advocates for our own health.

Coming Soon: Miami ReLife’s Dr. Steven Gelbard

The first series is with Dr. Steven Gelbard, a nationally-famed authority with his ReLife Miami Institute on stem cells. Dr. Gelbard presents D’OXYVA’s Nobel Prize-winning science as a regenerative medicine. Dr. Gelbard is involving his direct contacts with top NFL players and other top sports celebrities in the monthly series, along with 25—40 top neurosurgeons and other experts working under ReLife.

Imagine having the ability to receive D’OXYVA and other innovative treatments and non-invasive procedures for chronic wound care amid the luxury of a five-star hotel. Behind The Scenes guest, Dr. Gelbard, a Tufts School of Medicine educated neurosurgeon, makes it happen right now. Medicine has left the hospital building and has become the proactive choice of the health conscious. We can all look forward to learning more about how to live a healthier and more informed lifestyle from this awe-inspiring episode.

According to Norbert Kiss, President and CEO of Circularity Healthcare, this collaboration is door busting. Mr. Kiss tells us, ”[We] can offer unprecedented access to this amazing Emmy-winning show called Behind the Scenes with very amazing terms due to our strategic involvement. We welcome any expert.”

Laurence Fishburne, host of Behind The Scenes,” beckons, “Join me as we all discover the endless ways to enjoy the skills and imagination.”

Don’t miss the evolution. It’s being televised. Circularity and Behind The Scenes—Stay tuned for a mind-fortifying experience!

Circularity Values:

We, at Circularity believe in a long-sought-after goal in health care; people should have access to one health application that solves most of their short and long term health issues without compromising other aspects of their health while doing this quickly, affordably, and without pain.
Circularity develops, manufactures and markets advanced technologies that significantly improve quality of life by improving some of the most essential physiological functions in the body.

About Behind The Scenes With Laurence Fishburne

Behind The Scenes is an award-winning program that highlights new stories and innovative concepts through groundbreaking short-form and long-form documentary presentation. The program, which is anchored by a veteran production team with decades of industry experience, is able to effectively communicate the most critical stories to a wide and diverse audience.

Behind The Scenes with Laurence Fishburne, has established an impressive and heralded career, amassing over one-hundred credits across the varied platforms of stage, television and film. He’s well known for major for roles in such films as; John Wick 2, Fantastic 4 Rise of the Silver Surfer, Mission Impossible III, Mystic River, Boyz n the Hood, What’s Love Got to Do With It, and Apocalypse Now. On the small screen, the award-winning and versatile actor played compelling roles in shows such as CSI: Crime Scene Investigation, CSI: Miami, CSI: New York and Hannibal. The Behind The Scenes Actor currently stars as Pops on the hit TV comedy Black-ish.

About Circularity Healthcare, LLC

Circularity Healthcare, LLC, located in Los Angeles, CA is a private biotech and medtech products and services company that designs, makes, markets, sells, distributes and licenses its own patented and patent pending technologies, such as its flagship non-invasive deoxyhemoglobin vasodilator product line, D’OXYVA®. One of the main mechanisms underlying D’OXYVA’s science received the Nobel Prize for Medicine in 2019. Circularity enters into exclusive agreements with manufacturers to launch products and with large and small clinics and hospitals in order to help them enhance their profits and credit profiles with a wide variety of advanced products and services. In addition, Circularity Healthcare assists in the financing of equipment, working capital and also patient financing at industry-leading terms and speed.

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Disorders of Microcirculation – Prevention and Treatment

Microcirculation[1] involves the smallest branching blood vessels in the body, which are the arterioles, the venules and the capillaries. These tiny blood vessels provide essential perfusion to the tissues of the body and supply oxygen while carrying away toxic metabolic waste products. Disorders of microcirculation can affect all end organs of the body, such as through the cardiovascular system, the central nervous system, peripheral circulation to the lower extremities and blood flow to the eyes and to the kidneys. The following case study involves a patient with multiple disorders of microcirculation that were all improved by application with D’OXYVA[2]

Arnie F was a 64-year-old white male with a long history of uncontrolled type 2 diabetes mellitus for the last 13 years, hypertension, depression, cardiovascular disease and kidney disease.

Due to his uncontrolled diabetes mellitus, Arnie had developed peripheral neuropathy and 2 large non healing ulcers[3] over the malleolar areas on both feet and over the soles of both feet.

These ulcers had never completely healed over a 9-year period.

Arnie also reported severe pain in his legs and calves most nights, with a self-reported score of 7 out of a possible 10 on the visual pain scale.

On physical exam, Arnie had a blood pressure of 140/95 and a body mass index of 26.

He also had diminished pedal pulses on both feet along with 2+ edema of both lower extremities.

After application with D’OXYVA, which is a deoxyhemoglobin transdermal vasodilator, for 5 minutes twice a day for 25 days, Arnie’s previously non-healing foot ulcers were nearly completely healed and he avoided the need for amputation.

In addition, Arnie’s leg and foot pain was eliminated after 4 weeks of D’OXYVA, and his depression lifted without additional medications.

Finally, Arnie’s exertional chest pain, which was due to his cardiovascular disease,[4] was also relieved and he was now able to walk 2 blocks without shortness of breath or chest pain.

Common Conditions Caused by Impaired Microcirculation

There are a number of common conditions caused by defects in microcirculation. These include the following:

  • Non-healing diabetic foot ulcers
  • Depression
  • Chronic pain from diabetic neuropathy
  • Chronic pain from fibromyalgia
  • Chronic pain from chronic wounds
  • Chronic pain from degenerative arthritis
  • Chronic pain from rheumatoid arthritis
  • Chronic pain from osteoporosis
  • Chronic pain from migraine headaches
  • Chronic lower back pain
  • Cardiovascular diseases such as ischemic heart disease and hypertension
  • Obesity
  • Insulin resistance
  • Type 2 diabetes mellitus
  • Chronic renal failure
  • Peripheral vascular disease
  • Venous insufficiency
Conclusion

Disorders of microcirculation[5] affect many different organs and systems of the body including the cardiovascular system, the peripheral vascular system and the central nervous system. D’OXYVA has been shown to be an effective application in  many conditions such as nonhealing wounds of the lower extremities and depression and in increasing strength and endurance in patients with cardiovascular diseases.

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been validated to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

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Treating Microcirculation Defects in Cardiovascular Diseases

Defects in microcirculation have been documented as major factors in the development of cardiovascular diseases, especially type 1 diabetes.[1] By treating microcirculation defects, thus increasing blood and oxygen flow to the heart, the risk of recurrent significant cardiovascular events can be reduced significantly, and strength and endurance can improve. 

An example of microcirculation compromise in a patient with severe cardiovascular disease can be seen in the clinical case of Leo B.

Leo was a 64-year-old male with a medical history of diabetes mellitus for 15 years, cigarette smoking, elevated cholesterol, and high LDL (harmful blood fat) levels. 

Leo had a heart attack (myocardial infarction) several years ago.

He had suffered a myocardial infarction 6 weeks earlier and also suffered from exertional angina (chest pain with exertion).

He was taking lisinopril (20 mg per day) for high blood pressure, insulin for his diabetes, and one baby aspirin a day as a blood thinner to prevent another heart attack.

Leo was put on a cardiac rehabilitation regimen[2] consisting of a low-fat diet, moderate exercise, and stress control. 

He used D’OXYVA[3]as an adjunct application, which helped increase his strength and endurance while decreasing his episodes of exertional chest pain.

What is Microcirculation? 

In general, microcirculation[4] refers to the smallest blood vessels in the body, consisting of the arterioles, venules, and capillaries. 

These tiny blood vessels supply oxygen to the organs of the body and remove waste products produced by the body’s metabolism. 

Smooth muscle cells, which are the lining cells of the arterioles and of some venules, are under the control of the sympathetic and parasympathetic nervous systems and other chemical factors. 

These influences help control the ability of the microcirculatory system to dilate and contract to increase or decrease circulation and oxygenation.

What is Coronary Microcirculation? 

Coronary microcirculation (microvascular network) refers to the smallest arterioles and venules that supply the heart. 

These tiny branching blood vessels play crucial roles in supplying oxygen and removing waste products from the heart muscle. 

When the heart requires more oxygen, the arterioles dilate, increasing blood flow to the heart. 

This is especially important if a patient suffers from cardiovascular conditions such as angina or heart failure. 

What Causes Cardiac Microcirculation Dysfunction? 

Dysfunction of cardiac microcirculation can be caused by many factors, including:

  • Dysfunction of the endothelial (lining) cells of the arterioles, which affects the ability of arterioles to dilate and allow for increased blood flow
  • Increased alpha 2 adrenergic activity, which leads to vasoconstriction and resultant decreased cardiac perfusion
  • Sclerosing of the arterioles, causing reduced blood flow and oxygenation 
Conclusion 

Microcirculation consists of the smallest blood vessels in the body and includes cardiac microcirculation, which plays a crucial role in supplying oxygen and removing waste products from the heart. The transdermal deoxyhemoglobin vasodilator D’OXYVA plays an important role in increasing blood flow (perfusion) and resultant oxygenation to the cardiovascular system. This increase in oxygenation has been found to help increase endurance and strength and is an important adjunct solution to consider as part of cardiac rehabilitation.

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been clinically tested to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

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Signs You’re at Risk for Spider Veins

spider vein

Spider veins are dilated superficial blood vessels that often appear on the surface of the lower extremities or on the face. They are usually caused by damage to the small valves in veins, which causes backflow, increased pressure and venous dilation.

An example of a patient with spider veins is Helen R., a 38-year-old white female with a history of spider veins behind both knees and thighs bilaterally that developed after pregnancy.

Helen had a medical history of deep venous thromboses in both legs at the age of 35. She also had a history of smoking one pack of cigarettes per day for the past 25 years. Helen had gained 40 pounds during her pregnancy.

To treat her spider veins, Helen was placed on a treatment regimen with D’OXYVA,[1]  a transdermal deoxyhemoglobin microcirculation vasodilator. She was given 5-minute applications 5 times per week for 2 weeks, which eliminated all of her spider veins.

How Does D’OXYVA Eliminate Spider Veins?

D’OXYVA works to eliminate spider veins by delivering a mixture of water vapor and pharmaceutical grade CO2 under pressure through the surface of the skin to the microcirculation (the smallest blood vessels in the body), which improves and normalizes circulation and oxygenation.

D’OXYVA also works by balancing the effects of the autonomic nervous system (the sympathetic and parasympathetic nervous systems) to achieve a state of homeostasis.

Major Risk Factors for the Development of Spider Veins

There are a number of risk factors for the development of spider/varicose veins. These include:

  • Gender—Female patients have a much higher risk of developing spider veins[2]than male patients.
  • Genetic history—The majority of patients with spider veins have a close relative with spider veins.
  • Pregnancy—Pregnancy increases the downward pressure on veins in the lower extremities, leading to an increase in spider veins.
  • Weight—Obese patients have an increased body mass index, which puts added strain on the veins of the lower extremities, causing spider veins.
  • Age—With increasing age, the valves in the veins can become weaker, leading to backflow and pooling of blood in the veins, which increases venous pressure and causes spider veins.
  • Birth Control Pills—Patients on birth control pills have a higher risk of developing spider veins than women who are not on birth control pills.
  • Sitting/Standing for Long Periods of Time – Extended periods of sitting or standing without changing positions can lead to pooling of blood in the lower extremities, leading to the development of spider veins.
  • A History of Lower Extremity Blood Clots—Deep venous thromboses (DVTs), which are blood clots in the deep veins of the legs, can lead to damaged valves and resultant spider veins.
  • Hormonal Therapy—Patients on hormone replacement therapy for menopausal symptoms are also at increased risk for developing spider veins.
Ways to Decrease the Risks of Developing Spider Veins

To decrease the risk of developing spider veins,[3] here are some helpful suggestions:

  • Maintain a healthy diet and exercise program to establish a healthy weight.
  • Avoid sitting or standing for more than 30 minutes at a time.
  • Avoid crossing your legs when sitting for long periods of time, as this can decrease circulation.
  • Avoid wearing high heels for long periods of time, as this can reduce blood circulation in the calf muscles.
  • Elevate your feet whenever possible when taking a break from work or extended sitting or standing.

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been clinically tested to significantly improve microcirculation.

D’OXYVA® (deoxyhemoglobin vasodilator) has eliminated 97%* of all mild to severe so-called spider and varicose veins for both men and women users. Doing so while eliminating associated long-term pain within 2 to 4 weeks** by taking a single 5-minute application 5 times per week.

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5 Ways to Improve Your Mental Health

Improve Your Mental Health

By Dr. Steven Gelbard, MD, Medical Director of ReLife Miami Institute

Sometimes, a mental health issue manifests as emotional outbursts rather than chronic anxiousness or periods of depression. You may notice you’re overeating or not eating enough, so you had a recent change in your weight. You could be suffering from insomnia, frequently waking up through the night, or oversleeping. It’s possible to improve your mental state of health and improve your overall quality of life, though.

1. Change Your Diet

A mineral or vitamin deficiency may be the root of your anxiousness or depression. For instance, zinc has an impact on your mood. It’s possible to feel depressed if you have a zinc deficiency. Studies have shown a link with low zinc levels in their blood and depression. Moreover, it appears there’s a correlation between zinc levels and the severity of a person’s depression. Zinc is necessary for the release of certain hormones, including stress hormones. A zinc deficiency can also lead to aggravation. Zinc isn’t the only nutrient that can interfere with your happiness and mental health; so can B-complex vitamins, iron, and vitamin D, among others. Try to consume a diet rich in nutrients. If you can’t, consider supplementing.

2. Go for Regular Walks

It’s important to keep yourself active, even if you’re at your ideal weight. A walk can help reduce your stress and boost your energy levels. It’s also hindering you from using your electronic devices. Walking has the potential to boost your energy levels and help you to refocus your mind. After you begin walking regularly, you may notice your symptoms of depression are decreasing.

3. Take Time Each Day Without Electronic Devices

If it’s possible, spend time at some point during your day partaking in an activity besides playing on the tablet, using your cell phone, or watching television. The excessive use of electronic devices has been linked to depression and anxiety. The calls and emails can become overwhelmingly stressful. Plus, electronic devices emit blue light, which interferes with your body’s sleep schedule. Therefore, it’s particularly important to avoid devices immediately before bed.

4. Improve Your Sleep Habits

Your body requires sleep to revitalize itself and for your body to function normally the following day. If you’re not sleeping enough, it affects your neurotransmitter levels as well as your stress hormones. Ultimately, this takes a toll on your mental health. You may have difficulty regulating your emotions. This could lead to emotional outbursts, depression, and anxiety. Some ways to improve your sleep include avoid caffeine too close to bedtime and avoiding smoking before bed.

5. Consider Using D’OXYVA

D’OXYVA is a unique non-invasive device that releases a transdermal, medical-grade, supersaturated carbon dioxide vapor. As it penetrates through your skin, it optimizes your circulation even down to your small blood vessels. The blood flow through your smallest blood vessels is known as microcirculation, and it’s particularly important for your nerve function as well as the production of certain hormones. For instance, microcirculation plays a role in your adrenal gland. An insufficiency in the amount of adrenaline your body secretes can lead to changes in your personality and mood.

This therapy affects the autonomic nervous system, which is responsible for the tasks your body regulates on its own, such as your digestion, breathing, and heart rate. Issues within your autonomic nervous system can lead to issues like erectile dysfunction and blood pressure problems.

Your mental health has a profound impact on your quality of life. Fortunately, you can take steps to proactively improve your mental health through lifestyle changes. Additionally, you may want to consider trying D’OXYVA to optimize your mental and overall health and well-being.

About Dr. Steven Gelbard

Dr. Steven Gelbard, MD is a Neurosurgeon that has been in practice in Florida for almost 30 years. He graduated from Tufts University School Of Medicine and then did additional training at NYU, Brown University and Harvard Medical School affiliated Hospitals, as well as other prestigious institutions. He holds several US patents for medical inventions and has worked with professional sports teams including the NHL Florida Panthers hockey team, the NFL Miami Dolphins football team, and the ABA Florida Pitbulls basketball team. He is currently the Medical Director of the ReLife Miami Institute.

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What You Need to Know About Non-Healing Wounds

Chronic wounds are wounds that do not heal in a normal amount of time. This delay in healing can be due to a number of factors. Read on to learn about the case of a 63-year-old female patient with a large chronic wound on her lower, left extremity that was resistant to healing.Lena was a 63-year-old, White female who had developed a large, non-healing wound on her lower, right leg. She could not remember what had caused the lesion other than having dropped a heavy mirror on her right shin several weeks earlier. Lena had a past medical history of high blood pressure, diabetes, heart failure, liver failure, and blood clots in her legs. She had been a cigarette smoker for the last 50 years.Lena’s physical examination showed a large, deep, non-healing wound on her right shin. Surgical treatment and debridement, along with antibiotic treatment, had failed to result in significant treatment. After 8 weeks of adjunctive application with deoxyhemoglobin vasodilator D’OXYVA[1], the chronic wound improved without any further complications.
Main Reasons Chronic Wounds Do Not Heal
Chronic wounds normally do not heal for a number of reasons, including[2]:
  • Increased age of the patient leading to slower healing time
  • Decreased functioning of the immune system due to illnesses or chronic disease processes
  • Decreased circulation due to diabetes affecting the peripheral vascular system
  • Decreased circulation due to peripheral vascular disease
  • Peripheral neuropathy leading to loss of sensation and the inability to feel wound and ulcer formation
  • Insufficiency of the venous system leading to pooling of blood in the extremities and resultant poor perfusion
  • Poor nutrition leading to decreased ability to heal wounds normally
  • Impaired mobility leading to impaired limb perfusion
  • Increased general stress levels leading to decreased wound healing
  • Decreased general health causing general debilitation and loss of normal healing ability
Variations of Chronic Wounds

There are several different variations of chronic wounds, including pressure ulcers, arterial and venous ulcers, and diabetic ulcers.

Pressure ulcers[3], such as “bed sores,” occur when an area of the skin is under constant pressure, often when a patient is confined to a bed or wheelchair.

This causes the skin to break down in areas such as the coccyx, heel, ankles, and dorsum of the foot.

Arterial ulcers[4] form when there is a blockage in an artery causing reduction in blood flow to the lower extremities and subsequent reduction in the supply of oxygen to the affected area.

Venous ulcers[5] occur when the valves within veins become damaged leading to pooling of blood in the veins and reduced blow flow and oxygenation to the extremities.

Diabetic ulcers occur when high blood sugar levels cause damage to the nerves, especially in the lower extremities.

This leads to numbness, causing the patient to ignore cuts or ulcers until they enlarge, often becoming infected.

Diabetes also depresses the immune system, leading to slowed healing.

Treatments for Chronic Non-Healing Wounds

There are a number of treatments for non-healing wounds [7]. These include:

  • Antibiotics to treat bacterial infections
  • Antifungals to treat fungal infections
  • Hyperbaric oxygen treatments to improve chronic wound healing
  • Surgical debridement to remove necrotic tissue
  • Specialty wrapping of chronic wounds
  • Skin grafting to close chronic wounds
  • D’OXYVA[8]skin delivery deoxyhemoglobin vasodilator as a wound solution to improve blood flow and oxygenation to chronic wound areas

HOW D’OXYVA CAN HELP?

D’OXYVA® (deoxyhemoglobin vasodilator) provides advanced, painless, complete and fast wound care solution. It has demonstrated speeding up diabetic wound improvement to an average of 5 weeks**.

In addition, D’OXYVA  improved quality of life such as sleep, appetite and mood in just a week in 100% of subjects. No adverse events of any kind were reported during, and years after the studies.