Tag: wound healing

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Inspiring Story: The Case of C.A., “D’Oxyva is my game changer “

For two years, living has been like trying to survive between a rock and a hard place, as the saying goes. I’ve been on death’s door more than once, from intense chronic hip pain and loss of mobility to oozing leg wounds and infections; surgeons refused to do hip surgery because of my wounds. There were definitely times when I didn’t think I’d make it through.

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One day, my best friend, Mo, called me up very excited and told me to check out DOxyva.com. She said there was evidence online that the application could assist with wound healing. I was living a nightmare of constant pain, stress, and little hope, struggling just to get myself through the next 24 hours. I called D’Oxyva and spoke with John, grilling him with what felt like a thousand questions. I just did not want to get my hopes up just to crash with disappointment. I waited for a sign. Each time my thoughts circled back to D’Oxyva, I started to hear the words “game changer” in my head. When a friend called to check in on me and I described the concept to her, she said outright, “CA, I think this could be your game changer.” My eyes filled with tears.

I ordered a full kit with five boxes and didn’t look back.

I have been so very sick while waiting almost five years for a much-needed hip replacement surgery! I developed a non-diabetic lower leg wound (from a scratch), becoming wheelchair bound and unable to walk. After over 17 months suffering from severe wound complications, neuropathy and extreme lymphedema (from a drug allergy), I am absolutely thrilled to embrace the full force of my healing journey with twice-daily D’Oxyva application! After a few short weeks using D’Oxyva, not only has the swelling in my legs subsided, the skin around my wound has completely healed, and the wound itself continues to shrink from over 1.5 inches to less than ¼ of an inch in depth (see progress photos). I continue to drop inches from swelling throughout my body, and my physical strength improves every single day. Before I began D’Oxyva, I could barely stand for 5 minutes; now, I can manage 30-40 minutes! I sleep more deeply, my anxiety is disappearing and my stamina grows each day. My nurses, health care aides and doctors have observed the tremendous changes in me with excitement, anticipation and support from week to week.

I still have much healing to get through; however, I know that I would not be living this daily miracle if not for MY D’OXYVA! It Is my game changer!

Follow this blog if you like; as my D’OXYVA journey continues, I will be sharing my progress, challenges, fears and joys.

Thanks for taking the time to read this. I hope you find YOUR game changer!

My best to you,

C.A.

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Why Use D'OXYVA?

Increasing demand for painless drug delivery, coupled with rising demand for self-administration of drugs, is anticipated to fuel market growth. D’OXYVA® (deoxyhemoglobin vasodilator) is the only fully non-invasive, non-irritating, non-opioid, and completely painless, over-the-skin delivery nerve stimulant and microcirculatory solution with over seven years of industry-leading research results.

D’OXYVA® has been demonstrating for years that it does not break the skin’s barrier, while it provides exceptional quality of life and health benefits quickly and affordably. In short, based on current leading neurology, immunology, microvascular, and cellular oxygenation science, D’OXYVA® is leading the field by:

✔ Significantly lowering the risk of diabetes and cardiovascular complications.

✔ Providing complete significant improvement of difficult wounds together with major pain relief and improved quality of life.

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How a New Advanced Health Solution Underpinned by Nobel-winning Science Can Protect You by Targeting Underlying Conditions

Covid-19 underlying medical conditions

Patients dealing with underlying health issues, including diabetes and chronic heart conditions, as well as COVID-19, may find fast and painless relief from an advanced solution.

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An easy-to-use , commercially-available device, D’OXYVA (deoxyhemoglobin vasodilator) by Circularity Healthcare, LLC, delivers transdermal ultra-purified medical gas directly to the blood stream and body tissues that are low in oxygen-rich blood flow.

The handheld, lightweight device – which promotes  the rest and digest functions of the autonomic nervous system  and the circulation of the blood in the smallest blood vessels, known as microcirculation – has demonstrated over years of studies and user feedback great efficacy in treating a number of health issues, including treating and closing so-called non-healing diabetic wounds.

“D’OXYVA has shown significant promise for severe cases of diabetic foot ulcers,” says Dr. Michael McGlamry, a podiatrist in Georgia.

He says the device helps increase oxygen-rich blood flow in the local microcirculatory system, leading to better blood perfusion and tissue oxygenation.

“Improved microcirculation leads to better tissue oxygenation and better heart function, as the heart does not need to exert extra force to bring the blood to all the organs of the body,” says Dr. McGlamry.

Wound healing

Foot wounds are a significant concern for diabetics: 15% will develop a foot ulcer, and 14-24% of individuals with a foot ulcer, will need amputation.

Dr. Felix Sigal, a Los Angeles podiatrist, says this device is a game changer.

“Transdermal delivery of carbon dioxide has therapeutic effects on both the microcirculation and tissue oxygenation,” he says. “By improving tissue oxygenation and microcirculation, studies have shown greater progress in wound healing with respect to wound size and area of injury.”

The device was evaluated over eight years and three dozen human studies where zero adverse effects were reported. The CO₂ is approved by the FDA for anesthesia and oxygen therapy as a non-toxic, simple molecule under the Medical Gas Safety Act of 2012. It’s in the final phase of getting a combination device-drug approval.

“D’OXYVA has recorded significant results, delivering major outcomes for well over 90% of users,” says Dr. McGlamry.

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Applications for COVID-19 patients

The device may help improved blood flow and tissue oxygenation for people with COVID-19 . Patients most at risk for the novel coronavirus include those over 65 who have heart disease, liver disorders, diabetes or other underlying health issues.

“Because it affects the immune system and compromises the body’s natural defenses fight off infections, it is critical for a person with diabetes to have good blood flow circulation, reducing the chance of infection, ulcers and at worst case amputations,” says Dr. Geoffrey Watson, who specializes in chronic care management in Oakland, California.

He says while the heart is a far distance from the foot, the foot relies on the heart for consistent blood flow, requiring open pathways. Often those pathways are constricted in diabetics, resulting in poor blood circulation

Dr. Watson says vasodilation is essential, “to promote microcirculatory blood flow to supply adequate oxygenation the feet, thereby likely helping to prevent infections, ulcers and wounds.”

Clinical Trial

Circularity Healthcare’s pivotal clinical trial — which involves the use of an FDA-approved drug in addition to IDE device D’OXYVA® (deoxyhemoglobin vasodilator), a non-toxic, non-invasive  transdermal drug delivery device — is poised to help the most at-risk coronavirus patients experiencing complications due to diabetes, poor circulation, hypertension, high blood pressure, and cardiovascular disease.

“Further studies are needed but this device has the potential to prevent symmetrical peripheral gangrene, a limb threatening complication of COVID-19,” says Dr. Sigal, who is helping conduct the D’OXYVA pivotal diabetic foot ulcer clinical trials.

This clinical trial represents the first biotech solution to improve a patient’s overall oxygen-rich blood flow.

Source

https://doxyva.com/covid-19/

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Why Use D'OXYVA?

Experts say D’OXYVA® can help patients find relief. Overwhelming medical data shows people with preexisting conditions, including diabetes may experience serious complications with COVID-19.

D’OXYVA significantly helps people and their pets by gently and quickly spraying a patented and patent-pending ultra-purified, supersaturated solution on the skin surface to achieve major health benefits for well over 90% of users.

Experts call D’OXYVA a game-changer biotech. “Studies with D’OXYVA have shown unmatched results in noninvasive wound care,” Dr. Michael McGlamry. Anyone with an underlying condition should know this option is available.

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Non-Invasive Treatments: What No One Is Talking About

D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.

Sometimes it seems like the best way to guess a person’s age is by how much medicine they take daily. This system is not perfect, as some people start medications early in life, but we all seem to accumulate pills and creams as we age. That is why it can be a relief to discover an application that can be used for multiple health disorders.

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Alexa, a 58-year-old woman from Texas, United States, has suffered from type 2 diabetes for more than 6 years. She has been taking multiple medications and treatments such as inhibitors, metformin, pain relievers and antibiotics for her diabetic foot wound. After discovering D’OXYVA, a non-invasive application that significantly helped with her pain and wound management after 5 weeks of twice-daily application, she shared that she saved so much when she started decreasing the intake of other medications and avoided a possible amputation just by using this non-invasive application.

D’OXYVA, for example, can be applied for a variety of conditions related to poor circulation. This multi-application product helps consumers save money, space, and time while simplifying everyday life.

Here are a few things about non-invasive treatments that people seem unwilling to discuss.

In layman’s terms, non-invasive treatments do not break the skin or enter beyond the surface of body openings. Invasive treatments include surgery and injections. Because the needles actually penetrate the skin, acupuncture is also considered an invasive procedure. Certain procedures may be considered minimally invasive if they do not penetrate deeply into the body or only require a small incision.

Non-invasive procedures include massage and gas delivery systems such as D’OXYVA.

By nature, an invasive procedure can be hazardous. Even under a doctor’s care, for example, minimally invasive surgical procedures carry risks (Mayo Clinic). Patients can experience unforeseen complications related to anesthesia, infections, or bleeding. While these risks are mitigated with less serious regular treatments, any invasive procedure carries the potential for infections or bleeding complications.

While you should always trust your medical professional’s advice, many non-invasive treatments can be safer. Most doctors will attempt to find the least invasive, most effective treatment.

Although the human body contains many different cells and functional systems, most of them share the same basic processes. For example, every cell in the body depends on a healthy circulation system to receive nutrients and oxygen. Therefore, when a person has circulation problems, it can manifest as a number of issues. Your doctor may be able to recommend one product like D’OXYVA for multiple circulation-related issues.

Examples of Circulation Related Issues

  • Slow-healing wounds, especially those related to diabetes or other cardiovascular issues
  • Septic shock related to a severe infection or a compromised immune system
  • Many forms of chronic pain
  • Varicose veins and other blemishes

Reference(s):

https://www.mayoclinic.org/tests-procedures/minimally-invasive-surgery/about/pac-20384771

HOW D’OXYVA® CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless over-the-skin microcirculatory and nerve stimulant solution that has been validated to significantly improve microcirculation.The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.
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If you suffer from symptoms related to poor circulation, end your suffering in silence now!

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7 Things You Should Know About Diabetic Foot Care

diabetes success story

Diabetes can lead to complications[1] involving the feet, including peripheral neuropathic pain, diabetic foot ulcers, poor circulation, decreased sensation and increased callus formation. This can lead to skin breakdown and the formation of ulcers that can become infected and even lead to amputations. Proper diabetic foot care can decrease the risk of developing these complications. Read on to learn about the case of Chase L., who suffered from severe diabetes with complications involving both feet and who experienced significant pain relief through the application of the non-invasive deoxyhemoglobin vasodilator D’OXYVA[2]

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Chase was a 64-year-old male patient with a 7-year history of type 2 diabetes mellitus. He had high blood sugar levels for a 3-year period before his diagnosis, as well as a history of elevated cholesterol and triglycerides and high blood pressure. On laboratory testing, Chase had an A1C level of 8.3% (normal A1C levels are less than 5.7%) and a blood sugar reading of 186 (normal readings are 70-110).

On physical exam, Chase exhibited ingrown toenails, pallor of the feet, cyanosis of the toes and thick callus formation of the heels. In addition, he had decreased sensation over the dorsum of both feet and diminished pedal pulses bilaterally. After spending thousands of dollars on medications and trying various non-invasive treatments without relief, Chase experienced significant pain relief and a decrease in the cyanosis of his toes after 6 weeks of daily D’OXYVA applications and shared that he saved money by using D’OXYVA and beginning to wean off of other medications.

#1 Check Your Feet Carefully Every Day for Diabetes Induced Changes
Diabetic patients must check their feet carefully every day to look for suspicious areas of skin breakdown, color changes, callus formation and skin infections. Areas that are especially vulnerable to skin breakdown include the big toe, the heel and the areas between the toes. Diabetics are extremely vulnerable to damage to the microcirculation (smallest blood vessels) of the feet. The application of transdermal vasodilators such as D’OXYVA can increase peripheral oxygenation to avoid further nerve damage and other diabetes induced changes while improving wound healing and avoiding amputations.
#2 Wear Properly Fitting Shoes
Shoes that are too tight can impair circulation. Care should be taken to ensure a proper fit so that circulation is adequate and there is no inordinate friction or rubbing.
#3 Keep Your Feet Dry, Especially in the Winter
Excessive moisture caused by sweating of the feet can lead to increased bacteria growth, which can cause infections. Socks should be changed regularly in the winter especially, if they become wet.
#4 Use Moisturizer on Your Feet After Bathing
The nerve damage and vascular changes to the feet caused by diabetes lead to dysfunction of the moisturizing glands and result in increased dryness, which can cause further skin breakdown. Applying a moisturizer to the feet (but not between the toes) after bathing can restore lost moisture and reduce dryness.
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References:

1. https://www.diabetes.org/diabetes/complications/foot-complications
2. https://doxyva.com/

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless over-the-skin microcirculatory and nerve stimulant solution that has been validated to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

LEARN MORE ABOUT D'OXYVA

Experience Significant Pain Relief Now!

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The Next Big Thing in Diabetic Foot Pain Management

foot pain

Diabetes Mellitus Type 2 is a severe, chronic medical condition that affects approximately 23.1 million[1] patients in the United States (9.4% of the US population). In addition, each year, 800,000 people will be newly diagnosed with diabetes. Diabetes can lead to the development of blindness, strokes, end stage renal disease, heart disease and diabetic neuropathy. Read on to learn about the case of Leo, who suffered from severe diabetic peripheral neuropathy.

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Case of a Patient with Diabetic Foot Pain

Leo was a 64 year old male patient with a long history of diabetes type 2.

Leo had a history of smoking cigarettes for the past 25 years.

He also had a history of hypertension, which was well controlled with lisinopril.

In addition, Leo had elevated cholesterol levels controlled with the use of a statin.

He denied any history of anxiety or depression.

Leo complained of a burning, very painful feeling in his hands and feet, which kept him up at night.

He also had some problems maintaining his balance and noted attacks of burning pain on the soles of his feet, often when driving his car.

On physical examination, Leo exhibited ataxia, vertigo and decreased vibratory sensations over his lower extremities.

His reflexes and the pedal pulses of the lower extremities were both intact bilaterally.

Leo’s labs revealed a fasting blood sugar of 146 and a hemoglobin A1C level of 7.8% (normal is less than 5.7%).[2]

Leo’s B12, T3, T4 and TSH levels were all within normal levels.

He also had a BMI of 40%.

After application of the over-the-skin deoxyhemoglobin peripheral vasodilator, D’OXYVA, [3] over a 6 week period, all of Leo’s symptoms of diabetic neuropathy, including the burning, itching and painful feeling in his hands and feet stopped completely.

How is the Microcirculation Affected by Diabetes?

The microcirculation consists of the smallest blood vessels in the body, including the arterioles, venules and capillaries.

Consistently elevated blood sugar levels are considered to be the most important risk factor in the development of painful diabetic neuropathy.

Diabetic neuropathy usually begins to develop at the base of the toes and then subsequently affects the higher parts of the lower extremities.

The most common symptoms of diabetic neuropathy include numbness, a feeling of burning, tingling and “pins and needles.”

Other symptoms of diabetic neuropathy are muscular weakness of the lower extremities, poor coordination and ataxia.

Once the numbness increases, there can then be a loss of pain perception, which can lead to the development of foot ulcers, infections and even eventual amputations.

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How Does D’OXYVA Help Decrease Diabetic Foot Pain?

D’OXYVA is a non-invasive vasodilation applicator, which is placed over the thumb and delivers a vapor of pharmaceutical grade CO2 and water through the skin of the thumb and into the blood stream.

This CO2 is then transported by the microcirculation to the peripheral arterioles, which causes them to dilate, providing increased oxygen to the peripheral tissues.

This increased oxygenation then leads to a decrease of pain resulting from diabetic neuropathy.

Conclusion

Diabetic neuropathy can cause debilitating pain, which can affect sleep patterns and quality of life. Current treatments include the use of tricyclic antidepressants, antiarrhythmics, antiepileptics, opioids and topical creams. The application of the non-invasive, non-painful over-the-skin deoxyhemoglobin vasodilator, D’OXYVA, has been widely reported to significantly lower the levels of pain and discomfort caused by this common complication of diabetes.

References

  1. https://www.cdc.gov/diabetes/data/statistics/statistics-report.html
  2. https://www.webmd.com/diabetes/guide/glycated-hemoglobin-test-hba1c
  3. https://doxyva.com/
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HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless over-the-skin microcirculatory solution that has been validated to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

LEARN MORE ABOUT D'OXYVA
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D’OXYVA® improves dermal microcirculation and promotes wound healing in the diabetic foot (clinical trial update)

DOXYVA improves dermal microcirculation for diabetic foot ulcers

Prof. Puruhito and colleagues have released the results of three observational trials showing that D’OXYVA® (Circularity Healthcare LLC), a deoxyhemoglobin vasodilator, improves vasodilation in the treatment of diabetic foot ulcers (DFUs), boosts dermal microcirculation, and helps in the healing process of DFUs.

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D’OXYVA® is a circulatory and nerve stimulant. The system was used by Prof. Puruhito for CO2 transdermal delivery, which has been shown to produce higher oxygen unloading by hemoglobin, thereby increasing oxygen-rich blood flow in the local microcirculatory system1. This improved dermal microcirculation leads, in turn, to enhanced wound healing2.

The American Diabetes Association standards of care for DFUs refer to microvascular complications and their treatment via improvements in microcirculation; therefore, Prof. Puruhito’s team set out to test CO2 transdermal delivery via D’OXYVA® in their patients. They have been gathering data since 2015, which led to the following results.

During the course of a 5-day treatment, O2 saturation increased in patients treated with transdermal CO2 in comparison to controls (15 patients/group)3 over the whole measurement range (up to 120 minutes post application). Moreover, a consistent heart rate decrease was found in patients undergoing transdermal CO2 treatment. Furthermore, the perfusion index (PI) showed an upwards tendency in the treatment group, whereas it remained stable for untreated controls. See figure 1.

diabetic wound

Figure 1: Changes observed after a 5-day transdermal CO2 treatment with D’OXYVA®. H1-H5: pre-treatment, 10, 30, 60, 90, and 120 minutes after; blue trace: control, orange trace: treatment. (A) Changes in O2 saturation (B) Decrease in heart rate due to treatment (C) Masimo® measurements of PI.

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In light of these results, Prof. Puruhito’s team performed extra measurements of transcutaneous carbon dioxide (TcPCO2), O2 saturation, and PI in the 15 patients treated with D’OXYVA® for transdermal CO2 delivery3–5. This data show that the oxygen saturation reached almost 100% in some patients, whereas the TcPCO2 remained relatively stable throughout the treatment time (120 minutes). For more detailed information, see figure 2.

Figure 2: Transcutaneous CO2 pressure (TcPCO2), O2 saturation, and PI assessment in the 15 patients subjected to transdermal CO2. (A) SENTEC TcPCO2 measurements for all patients at various time points after D’OXYVA® application (pre-treatment, 5, 60, 90, and 120 minutes after) (B) O2 saturation (C) PI.

Finally, Prof. Puruhito’s team demonstrated the positive effects of transdermal CO2 delivery via D’OXYVA® on the healing of DFUs5 (fig. 3), proving the clinical potential of this intervention to improve the quality of life of people suffering from this common complication of diabetes.

Figure 3 Wound healing after 5-day treatment with transdermal CO2 delivery via D’OXYVA® in cases of DFU Wagner-1 and Wagner-2

In conclusion, the use of a D’OXYVA® device for transdermal CO2 delivery improves the outcomes of DFUs by enhancing dermal microcirculation and increasing perfusion rates and tissue oxygenation, therefore assisting in the healing process of the ulcers typical of diabetes neuropathy.

About Prof. Ito Puruhito

Ito Puruhito, MD is professor in the Department of Thoracic and Cardiovascular Surgery at Dr. Soetomo General Hospital as well as a senior lecturer in the Faculty of Medicine at Universitas Airlangga (Indonesia). From 2001 to 2016, he was the rector of the aforementioned university. Prof. Puruhito finished his medicine studies at Universitas Airlangga in 1967, and in 1972 he received a doctorate degree, graduating cum laude from Frederich-Alexander University (Erlangen-Nürnberg, Germany). In his native country, he developed the Department of Thoracic-Cardiovascular Surgery at his former university, Universitas Airlangga, Surabaya. In 1978, he co-founded the Indonesian Association of Thoracic, Cardiac and Vascular Surgery. Prof. Puruhito has authored numerous indexed research articles in Scopus, ISI-Thompson or PUBMED, and scientific presentations and written several books in Indonesian, English, and German. He acted as reviewer for peer-reviewed journals such as Medical Tribune, Annals of Thoracic and Cardiovascular Surgery, Asian Annals of Surgery, Medicinus, and many more Indonesian medical-surgical journals. Currently, apart from lecturing, Prof. Puruhito actively researches stem cells, cardiovascular medicine, and surgery at the Institute of Tropical Disease as well as some work in microcirculation. Further, he acts as coordinator of research affairs at the Department of TCV-Surgery at Dr. Soetomo General Hospital Surabaya. Since 2014, he has been the chairman of the Council of Research in the Ministry of Research Technology and Higher Education of the Republic of Indonesia.

Source

https://www.prweb.com/releases/doxyva_improves_dermal_microcirculation_and_promotes_wound_healing_in_the_diabetic_foot/prweb16824221.htm

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Blog Posts

physician-recommended, easy to use daily

Why Use D'OXYVA?

Experts say D’OXYVA® can help patients find relief. Overwhelming medical data shows people with preexisting conditions, including diabetes may experience serious complications with COVID-19.

D’OXYVA significantly helps people and their pets by gently and quickly spraying a patented and patent-pending ultra-purified, supersaturated solution on the skin surface to achieve major health benefits for well over 90% of users.

Experts call D’OXYVA a game-changer biotech. “Studies with D’OXYVA have shown unmatched results in noninvasive wound care,” Dr. Michael McGlamry. Anyone with an underlying condition should know this option is available.

READ EXPERT INTERVIEWS

Reduce unwanted doctor visits, recommended and ranked top by experts!

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Disorders of Microcirculation – Prevention and Treatment

D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.

Microcirculation[1] involves the smallest branching blood vessels in the body, which are the arterioles, the venules and the capillaries. These tiny blood vessels provide essential perfusion to the tissues of the body and supply oxygen while carrying away toxic metabolic waste products. Disorders of microcirculation can affect all end organs of the body, such as through the cardiovascular system, the central nervous system, peripheral circulation to the lower extremities and blood flow to the eyes and to the kidneys. The following case study involves a patient with multiple disorders of microcirculation that were all improved by application with D’OXYVA. [2]

Arnie F was a 64-year-old white male with a long history of uncontrolled type 2 diabetes mellitus for the last 13 years, hypertension, depression, cardiovascular disease and kidney disease.

Due to his uncontrolled diabetes mellitus, Arnie had developed peripheral neuropathy and 2 large non healing ulcers[3] over the malleolar areas on both feet and over the soles of both feet.

These ulcers had never completely healed over a 9-year period.

Arnie also reported severe pain in his legs and calves most nights, with a self-reported score of 7 out of a possible 10 on the visual pain scale.

On physical exam, Arnie had a blood pressure of 140/95 and a body mass index of 26.

He also had diminished pedal pulses on both feet along with 2+ edema of both lower extremities.

After application with D’OXYVA, which is a deoxyhemoglobin transdermal vasodilator, for 5 minutes twice a day for 25 days, Arnie’s previously non-healing foot ulcers were nearly completely healed and he avoided the need for amputation.

In addition, Arnie’s leg and foot pain was eliminated after 4 weeks of D’OXYVA, and his depression lifted without additional medications.

Finally, Arnie’s exertional chest pain, which was due to his cardiovascular disease,[4] was also relieved and he was now able to walk 2 blocks without shortness of breath or chest pain.

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Common Conditions Caused by Impaired Microcirculation

There are a number of common conditions caused by defects in microcirculation. These include the following:

  • Non-healing diabetic foot ulcers
  • Depression
  • Chronic pain from diabetic neuropathy
  • Chronic pain from fibromyalgia
  • Chronic pain from chronic wounds
  • Chronic pain from degenerative arthritis
  • Chronic pain from rheumatoid arthritis
  • Chronic pain from osteoporosis
  • Chronic pain from migraine headaches
  • Chronic lower back pain
  • Cardiovascular diseases such as ischemic heart disease and hypertension
  • Obesity
  • Insulin resistance
  • Type 2 diabetes mellitus
  • Chronic renal failure
  • Peripheral vascular disease
  • Venous insufficiency
Conclusion

Disorders of microcirculation[5] affect many different organs and systems of the body including the cardiovascular system, the peripheral vascular system and the central nervous system. D’OXYVA has been shown to be an effective application in  many conditions such as nonhealing wounds of the lower extremities and depression and in increasing strength and endurance in patients with cardiovascular diseases.

References

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471451/
  2. https://doxyva.com/
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338469/
  4. https://spectrum.diabetesjournals.org/content/21/3/160
  5. https://www.jvascsurg.org/article/S0741-5214(05)00879-7/abstract

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HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless over-the-skin microcirculatory solution that has been validated to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

LEARN MORE ABOUT D'OXYVA
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What You Need to Know About Non-Healing Wounds

D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.
Chronic wounds are wounds that do not heal in a normal amount of time. This delay in healing can be due to a number of factors. Read on to learn about the case of a 63-year-old female patient with a large chronic wound on her lower, left extremity that was resistant to healing.Lena was a 63-year-old, White female who had developed a large, non-healing wound on her lower, right leg. She could not remember what had caused the lesion other than having dropped a heavy mirror on her right shin several weeks earlier. Lena had a past medical history of high blood pressure, diabetes, heart failure, liver failure, and blood clots in her legs. She had been a cigarette smoker for the last 50 years.Lena’s physical examination showed a large, deep, non-healing wound on her right shin. Surgical treatment and debridement, along with antibiotic treatment, had failed to result in significant treatment. After 8 weeks of adjunctive application with deoxyhemoglobin vasodilator D’OXYVA[1], the chronic wound improved without any further complications.
Main Reasons Chronic Wounds Do Not Heal
Chronic wounds normally do not heal for a number of reasons, including[2]:
  • Increased age of the patient leading to slower healing time
  • Decreased functioning of the immune system due to illnesses or chronic disease processes
  • Decreased circulation due to diabetes affecting the peripheral vascular system
  • Decreased circulation due to peripheral vascular disease
  • Peripheral neuropathy leading to loss of sensation and the inability to feel wound and ulcer formation
  • Insufficiency of the venous system leading to pooling of blood in the extremities and resultant poor perfusion
  • Poor nutrition leading to decreased ability to heal wounds normally
  • Impaired mobility leading to impaired limb perfusion
  • Increased general stress levels leading to decreased wound healing
  • Decreased general health causing general debilitation and loss of normal healing ability
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Variations of Chronic Wounds

There are several different variations of chronic wounds, including pressure ulcers, arterial and venous ulcers, and diabetic ulcers.

Pressure ulcers[3], such as “bed sores,” occur when an area of the skin is under constant pressure, often when a patient is confined to a bed or wheelchair.

This causes the skin to break down in areas such as the coccyx, heel, ankles, and dorsum of the foot.

Arterial ulcers[4] form when there is a blockage in an artery causing reduction in blood flow to the lower extremities and subsequent reduction in the supply of oxygen to the affected area.

Venous ulcers[5] occur when the valves within veins become damaged leading to pooling of blood in the veins and reduced blow flow and oxygenation to the extremities.

Diabetic ulcers occur when high blood sugar levels cause damage to the nerves, especially in the lower extremities.

This leads to numbness, causing the patient to ignore cuts or ulcers until they enlarge, often becoming infected.

Diabetes also depresses the immune system, leading to slowed healing.

Treatments for Chronic Non-Healing Wounds

There are a number of treatments for non-healing wounds [7]. These include:

  • Antibiotics to treat bacterial infections
  • Antifungals to treat fungal infections
  • Hyperbaric oxygen treatments to improve chronic wound healing
  • Surgical debridement to remove necrotic tissue
  • Specialty wrapping of chronic wounds
  • Skin grafting to close chronic wounds
  • D’OXYVA[8]skin delivery deoxyhemoglobin vasodilator as a wound solution to improve blood flow and oxygenation to chronic wound areas

References

  1. https://doxyva.com/category/wound-healing/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903966/
  3. http://ccn.aacnjournals.org/content/33/6/57.full
  4. https://www.woundsource.com/patientcondition/arterial-ulcers
  5. https://www.upmc.com/services/heart-vascular/conditions-treatments/venous-ulcers
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317316/
  7. https://www.vitals.com/education/careguides/non-healing-wounds/diagnosis-and-treatment
  8. https://doxyva.com/

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HOW D’OXYVA CAN HELP?

D’OXYVA® (deoxyhemoglobin vasodilator) provides advanced, painless, complete and fast wound care solution. It has demonstrated speeding up diabetic wound improvement to an average of 5 weeks**.

In addition, D’OXYVA  improved quality of life such as sleep, appetite and mood in just a week in 100% of subjects. No adverse events of any kind were reported during, and years after the studies.

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Prevention of Amputations in Diabetics

Prevention of Amputations in Diabetics

A major risk of having diabetes is the possibility of requiring an amputation. Most frequently, amputations due to diabetes first involve the great toe with worsening gangrene, which leads to amputation of the foot, amputation of the leg below the knee, and then amputation of the leg above the knee. The following is a case study of Douglas, who was a diabetic patient who required an amputation of his lower leg beneath the knee in order to survive.

Case of a Sixty-Three-Year-Old Man with an Amputation of the Left Lower Leg from Uncontrolled Diabetes

Douglas was a sixty-three-year-old patient with a past medical history that was significant for Type 2 diabetes mellitus and high blood pressure with an inability to walk more than two blocks without shortness of breath. Because his blood sugars were continually out of control even on insulin, Douglas developed damage to the nerves in his feet (peripheral neuropathy). This led to his inability to feel an ulcer forming on the tip of his left great toe. In addition, since his diabetes led to damage to the microcirculation (smallest blood vessels) in his feet, his ability to rapidly improve  from the ulcer was significantly delayed. Within forty-five days of the first occurrence of the blister, it became infected, which led to gangrene and sepsis and admission into the intensive care unit. The gangrene kept spreading, requiring first the amputation of his left great toe, then the amputation of his left foot, and finally the amputation of his entire left leg below the left knee. This case demonstrates how the extreme and potentially deadly risk of leg amputations in diabetics can be reduced through early diagnosis of the problem and aggressive preventative care, including the use of D’OXYVA[1].

D’OXYVA is a peripheral and noninvasive deoxyhemoglobin vasodilator that dilates the microcirculation (D’OXYVA delivers pharmaceutical grade CO2 and water vapor transdermally (through the skin), dilating the smallest veins, arteries, and capillaries while increasing peripheral blood flow to the lower extremities. D’OXYVA is a pain reliever that is given for fast pain relief treatments, which are known to reduce pain and chronic conditions.

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Risk Factors for Amputations in Diabetics

In a study published in the Journal of Developing Countries in 2008, it was found that, of 146 diabetic patients studied who had amputations of the foot, 74% had had diabetes for two to forty years.

In addition, forty-seven percent of the patients who were studied had ischemia (reduced blood flow), and forty-four percent had neuropathy (reduced nerve function) of the foot involved.[2]

How to Decrease the Risk of an Amputation Due to Diabetes?

Steps you can take to decrease the risk of an amputation if you are diabetic [3] include:

  • Keep your blood sugars well under control to decrease the risk of peripheral neuropathy and peripheral vascular disease.
  • Check blood sugars as directed by your physician.
  • Check your feet and toes for changes in temperature or feeling every day.
  • Examine your feet daily for cracks, blisters, cuts, redness, white areas, thick calluses, and different changes in color.
  • Stop smoking.
  • Stay on a Diabetic diet.
  • Increase daily exercise levels.
  • Continue to take all prescribed medications.

References:

https://doxyva.com/category/wound-healing/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772008/

https://www.webmd.com/diabetes/amputation-diabetes#1

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HOW D’OXYVA CAN HELP?

In an ongoing multi-year, multi-country, multi-center, randomized clinical trial on patients with diabetic foot ulcers, D’OXYVA has demonstrated speeding up diabetic wound improve and ultimately wound closure to an average of 5 weeks**.

In addition, D’OXYVA eliminated pain and improved quality of life such as sleep, appetite and mood in just a week in 100% of subjects. No adverse events of any kind were reported during, and years after the studies.

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Why Good Blood Circulation Is Important for Overall Health

D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.

Proper blood circulation is the most important function of the human body, and it can play a very big role in one’s overall health. One of the vital components of the body, which is involved in this function, is the heart.

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People often underestimate the important role of lifestyle choices on blood circulation, which can be significantly hindered by those choices. The following can negatively affect blood circulation:

  • Smoking
  • Not doing regular physical exercise
  • Leaving blood clots untreated
  • Having certain illnesses like heart diseases or diabetes

Patients suffering from poor blood circulation issues must consult Circularity Healthcare for advice and treatment.

The following are ways that blood circulation can impact a person’s health:

Benefits of good blood circulation

The following are a few benefits of good blood circulation:

  1. The body can maintain healthy oxygen and blood flow, which will allow the heart, lungs and muscles to function properly and efficiently.
  2. The body can avoid and fight diseases and sicknesses. In addition, white blood cells in the immune system can be transported around the body as needed.
  3. The organs will remain in proper working order and help remove waste from the body.
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Risks of poor blood circulation

The following are a few effects of having poor blood circulation:

  1. One may feel a lack of energy, inability to concentrate and excessive tiredness.
  2. Limited oxygen flow to the brain can cause memory glitches.
  3. Women may suffer from hair loss or alopecia.
  4. Men may suffer from erectile dysfunction.
  5. Sores and cuts may take much longer to heal.
  6. Poor blood circulation may cause amputation of the affected limb.

How can one improve circulation?

To improve blood circulation, a person needs to make a few lifestyle changes. The following tips can help:

  1. Doing yoga involves the stretching and bending of the body to different postures for a certain duration. In the beginning, it may be little difficult, but soon with regular practice, one can achieve the desired results.
  2. Massages can be another great way of relaxing and unwinding. This can also help in bonding well with a partner.
  3. Engaging in certain cardiovascular exercises can help one maintain a healthy weight and can improve blood circulation.
  4. It is also important to keep the body well hydrated by drinking enough liquids, including water, to flush out all the toxins present in the blood.
  5. Many people are not aware that eating seafood can also improve blood circulation because of the omega-3 fatty acids it contains. A few of the healthiest choices are salmon, tuna, mackerel and sardines.

People suffering from poor blood circulation always risk getting blood clots and must contact a physician or healthcare professional for proper advice on improving blood circulation.

Reference(s):

http://gccexchange.com/blog/what-is-blood-circulation-and-why-its-so-important/

https://niveinclinic.com/why-good-blood-circulation-is-vital-to-your-health/

https://www.livestrong.com/article/323211-benefits-of-increased-blood-circulation/

https://www.livestrong.com/article/323211-benefits-of-increased-blood-circulation/

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physician-recommended, easy to use daily

Why Use D'OXYVA?

Increasing demand for painless drug delivery, coupled with rising demand for self-administration of drugs, is anticipated to fuel market growth. D’OXYVA® (deoxyhemoglobin vasodilator) is the only fully non-invasive, non-irritating, non-opioid, and completely painless, over-the-skin delivery nerve stimulant and microcirculatory solution with over seven years of industry-leading research results.

D’OXYVA® has been demonstrating for years that it does not break the skin’s barrier, while it provides exceptional quality of life and health benefits quickly and affordably. In short, based on current leading neurology, immunology, microvascular, and cellular oxygenation science, D’OXYVA® is leading the field by:

✔ Significantly lowering the risk of diabetes and cardiovascular complications.

✔ Providing complete significant improvement of difficult wounds together with major pain relief and improved quality of life.

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