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Vaginal Microcirculation: Non-Invasive Anatomical Examination of the Micro-Vessel Architecture, Tortuosity and Capillary Density

D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.
Aim
To describe the vaginal microcirculatory architecture and capillary density parameters using side stream dark field imaging (SDFI), and determine feasibility and reliability of this method.
Methods
In nine healthy female volunteers SDFI measurements were performed at two different time points in the luteal phase of the menstrual cycle. Non-invasivetissue micro-angioarchitecture and vaginal capillary density measurements were assessed independently by two observers. Agreement was expressed with mean differences between the measurements of both observers and the limits of agreement. Inter- and intra-observer agreement was quantified with the intra-class  correlation coefficient (ICC).
Results
Vaginal microcirculatory assessment with the SDFI device was easy in use, painless and well accepted by theparticipants. Morphologically, the vaginal microcirculation revealed an array of single hairpin-shaped capillary loopsdistributed homogeneously across an imaged tissue segment. The intra-observer assessment of the capillary densitymeasurements (comparing two measurement time points of one observer) showed good agreement with an ICC ranging from 0.62 to 0.85. The inter-observer assessments of the capillary density measurements (comparing assessments of two observation timepoint)revealed very good agreement, with small differences between observers and an ICC of more than 0.9.
Conclusions
This is the first report on both microcirculatory architecture and quantitative microcirculatory parameters of the vagina with the use of SDFI. Micro-vessels of the vagina show a recognizable pattern in our study population of young, healthy women. SDFI gives a reproducible assessment of the vaginal microcirculation offering the researcher a wide field of applications.

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D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been clinically tested to significantly improve microcirculation.


The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

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Men With Erectile Dysfunction May Also Want To See A Heart Doctor

Heart love

Troubles in the bedroom can be a double whammy for older men: Researchers have found that erectile dysfunction ups the risk for heart disease.

Their four-year study concluded that men whose impotence is vascular-related, not emotional, are twice as likely to suffer a heart attack, stroke or sudden cardiac death.

This was true even without other heart risk factors such as high blood pressure, high cholesterol or a history of smoking.

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“The magnitude of the effect was surprising to me,” said study author Dr. Michael Blaha.

The findings suggest doctors should aggressively manage other risks such as high blood pressure or high cholesterol in men with erectile dysfunction, said Blaha. He is director of clinical research with the Johns Hopkins Center for the Prevention of Heart Disease in Baltimore.

The link between impotence and heart disease appears to be “a two-way street,” Blaha said, given that men who have had a heart attack appear to face a higher risk for ED.

For this study, the investigators tracked the heart health of about 1,900 men, ages 60 to 78, with and without vascular-related impotence.

Vascular impotence “is at its root a cardiovascular problem,” Blaha said. Unlike impotence related to anxiety or other psychological concerns, vascular ED stems from arterial blockage and insufficient blood flow.

“ED may be a sign of subclinical cardiovascular dysfunction,” said Blaha.

Experts have long observed that impotence is associated with poor cardiovascular health, but it was thought that obesity, high blood pressure and diabetes were some of the reasons why.

This study found that impotence on its own is a significant risk factor.

“In addition, this signal for increased risk is independent of depression and medication usage, said Blaha. That appears to negate theories that depression or its treatment might explain any link between impotence and heart disease.

Study participants were enrolled in the Multi-Ethnic Study of Atherosclerosis, conducted in several U.S. cities. Over four years, 115 men had a serious heart problem, such as heart attack, stroke or cardiac arrest.

The investigators determined that just over 6 percent of men with ED experienced such an event, compared with just under 3 percent of sexually healthy men.

So what should an impotent man do?

Blaha suggested a visit to a doctor or a preventive cardiologist. “In some cases, these men need screening for early cardiovascular disease,” he said.

“Many men at risk for cardiovascular disease seek medical care not for management of risk factors, but for their ED. Our study is an alert that such patients need a thorough cardiovascular evaluation in addition to their treatment for ED,” Blaha said

Dr. Richard Becker, an American Heart Association spokesman, said the study results need confirmation. Still, the strength of the findings were “striking,” he said.

“Health care providers should consider including ED as a component of assessing cardiovascular risk among middle-aged men,” said Becker, a professor of medicine at the University of Cincinnati who was not involved with the study.

“While there are effective treatments for ED, one must never overlook an opportunity to ask a simple question: ‘Why?’ In addition, men should be aware of the potential implications of ED and inform their provider,” Becker said.

The findings were published June 11 in Circulation.

Source(s): https://www.cbsnews.com/news/men-with-erectile-dysfunction-may-also-want-to-see-a-heart-doctor/

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Why Use D'OXYVA?

Increasing demand for painless drug delivery, coupled with rising demand for self-administration of drugs, is anticipated to fuel market growth. D’OXYVA® (deoxyhemoglobin vasodilator) is the only fully non-invasive, non-irritating, non-opioid, and completely painless, over-the-skin delivery nerve stimulant and microcirculatory solution with over seven years of industry-leading research results.

D’OXYVA® has been demonstrating for years that it does not break the skin’s barrier, while it provides exceptional quality of life and health benefits quickly and affordably.

In short, based on current leading neurology, immunology, microvascular, and cellular oxygenation science, D’OXYVA® is leading the field by: Significantly lowering the risk of diabetes and cardiovascular complications. Providing complete significant improvement of difficult wounds together with major pain relief and improved quality of life.

Reduce unwanted doctor visits, recommended and ranked top by experts!

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4 things you should know about erectile dysfunction

Erectile dysfunction

Erectile dysfunction (ED), once shrouded in secrecy, is now in the spotlight, thanks to high-profile advertisements for drugs like Cialis, Viagra, Levitra, and Stendra. But despite this greater awareness of ED, many men — and women — don’t really know much about this condition. Here are four things to know about ED.

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1. ED is often the result of diseases or conditions that become more common with age. It can also be a side effect of the medications used to treat them. Other possible causes of ED include prostate surgery, stress, relationship problems, and depression.

2. Other age-related factors besides disease can also affect a man’s ability to have an erection — for example, with age, tissues become less elastic and nerve communication slows. But even these factors don’t explain many cases of ED.

3. Cardiovascular disease is a common cause of ED. Clogged arteries (atherosclerosis) affect not only the blood vessels of the heart, but those throughout the body as well. In fact, in up to 30% of men who see their doctors about ED, the condition is the first hint that they have cardiovascular disease.

4. Intriguing findings from the Massachusetts Male Aging Study suggest there may be a natural ebb and flow to ED — that is, for some men, trouble with erections may occur, last for a significant amount of time, and then partly or fully disappear without treatment.

Regardless of the cause, ED often can be effectively addressed. For some men, simply losing weight and exercising more may help.

Others may need medications, and there are other options available as well. Given the variety of therapies available, the possibility of finding the right solution is greater than ever.

physician-recommended, easy to use daily

Why Use D'OXYVA?

Increasing demand for painless drug delivery, coupled with rising demand for self-administration of drugs, is anticipated to fuel market growth. D’OXYVA® (deoxyhemoglobin vasodilator) is the only fully non-invasive, non-irritating, non-opioid, and completely painless, over-the-skin delivery nerve stimulant and microcirculatory solution with over seven years of industry-leading research results.

D’OXYVA® has been demonstrating for years that it does not break the skin’s barrier, while it provides exceptional quality of life and health benefits quickly and affordably. In short, based on current leading neurology, immunology, microvascular, and cellular oxygenation science, D’OXYVA® is leading the field by:

Significantly lowering the risk of diabetes and cardiovascular complications.

Providing complete significant improvement of difficult wounds together with major pain relief and improved quality of life.

Reduce unwanted doctor visits, recommended and ranked top by experts!