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99% of Those Who Died From Virus Had Other Illness, Italy Says

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More than 99% of Italy’s coronavirus fatalities were people who suffered from previous medical conditions, according to a study by the country’s national health authority.

After deaths from the virus reached more than 2,500, with a 150% increase in the past week, health authorities have been combing through data to provide clues to help combat the spread of the disease.

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Prime Minister Giuseppe Conte’s government is evaluating whether to extend a nationwide lockdown beyond the beginning of April, daily La Stampa reported Wednesday. Italy has more than 31,500 confirmed cases of the illness.

 

Italy Coronavirus Deaths

By prior illnesses (%)

Source: ISS Italy National Health Institute, March 17 sample

 

The new study could provide insight into why Italy’s death rate, at about 8% of total infected people, is higher than in other countries.

The Rome-based institute has examined medical records of about 18% of the country’s coronavirus fatalities, finding that just three victims, or 0.8% of the total, had no previous pathology. Almost half of the victims suffered from at least three prior illnesses and about a fourth had either one or two previous conditions.

 

Threat to the Elderly

The median age of the infected is 63 but most of those who die are older
The average age of those who’ve died from the virus in Italy is 79.5. As of March 17, 17 people under 50 had died from the disease. All of Italy’s victims under 40 have been males with serious existing medical conditions.

While data released Tuesday point to a slowdown in the increase of cases, with a 12.6% rise, a separate study shows Italy could be underestimating the real number of cases by testing only patients presenting symptoms.

According to the GIMBE Foundation, about 100,000 Italians have contracted the virus, daily Il Sole 24 Ore reported. That would bring back the country’s death rate closer to the global average of about 2%.

Threat to the Elderly

HOW D’OXYVA CAN HELP?

Circularity is already in Phase 3 human clinical trials with most of the top ten U.S. university research institutions with D’OXYVA for FDA approval for rapidly treating chronic conditions such as diabetic wounds and hypertension, and fighting against COVID-19 with an already FDA-approved simple, non-toxic, and widely used molecule in nearly all hospitals around the world.

D’OXYVA is the only fully noninvasive, completely painless over-the-skin microcirculatory and nerve stimulant solution that has been validated to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

Reduce unwanted doctor visits, recommended and ranked top by experts!

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5 Preexisting Conditions That Can Make It Harder to Fight Coronavirus

D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.

Early data from China, where the new coronavirus COVID-19 first started, shows that some people are at higher risk of serious health complications from the new coronavirus. Per the Centers for Disease Control and Prevention (CDC), this includes people who have serious chronic medical conditions like heart disease, diabetes, lung disease, and mental health conditions such as depression and anxiety. 

That is why it can be a relief to discover an application that can be used for multiple health disorders that will help you save more money and that can be used at the comfort of your home just like with D’OXYVA application.

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Here’s why the following conditions increase the risk for COVID-19 complications—and what you should do if you’re affected. 

People with heart disease tend to have other underlying conditions like high blood pressure, elevated cholesterol, diabetes, and lung disease, which weaken the body’s health defense systems (including the immune system) against a viral infection, William Li, MD, physician scientist and author of Eat To Beat Disease: The New Science of How Your Body Can Heal Itself, tells Health. 

“The fever associated with COVID-19 puts additional strain on the body’s metabolic demands, stressing out the already weakened heart,” explains Dr. Li. “Pneumonia, which is commonly seen with COVID-19, makes it harder for the lungs to oxygenate the blood. This puts further stress on the heart.” Plus, inflammation caused by the infection can damage the lining of blood vessels through which the heart pumps blood. 

In February, the American College of Cardiology issued a bulletin to warn patients about the potential increased risk of COVID-19 that included additional precautions to take. The bulletin recommends that people with cardiovascular disease stay up to date with vaccinations, including for pneumonia, and get a flu shot to prevent another source of fever. 

Dr. Li advises regular exercise (while social distancing, of course) and a healthy diet to help strengthen the heart during the COVID-19 era. 

Chronic respiratory diseases (CRDs), which include asthma and pulmonary hypertension, are diseases of the airways and other parts of the lung. People with CRDs need to be especially vigilant about the coronavirus because one of the possible complications is pneumonia. “Pneumonia compromises the lung, which brings oxygen to the body,” explains Dr. Li. “In patients who already have a chronic respiratory disease, it can be lethal.” 

Besides following the CDC guidelines for handwashing, social distancing, and other coronavirus preventive steps, The COPD Foundation has issued further advice for people with chronic obstructive pulmonary disease (such as chronic bronchitis or emphysema). As reported in Pulmonary Advisor, this includes having at least a 30-day supply of all required medications on hand. If a patient requires an oxygen supply, they should contact their supplier to find out how to prepare for a COVID-19 outbreak in their area. 

Last week, actor Tom Hanks revealed on Instagram that he and his wife, Rita Wilson, tested positive for COVID-19. Hanks previously shared that he has type 2 diabetes, which means he’s at an increased risk of serious illness from the new coronavirus. 

What makes the coronavirus so dangerous for people with diabetes? First, because the immune system is compromised, it’s harder for the body to fight off the coronavirus, states the International Diabetes Foundation (IDF). Viruses also may thrive when blood glucose levels are high. 

People with diabetes have heightened levels of inflammation throughout their bodies, which is another risk factor. “If you have a viral infection, that can turn into pneumonia easier, because diabetes itself is an inflammatory disease,” Maria Pena, MD, director of endocrine services at Mount Sinai Doctors Forest Hills, previously told Health. “It’s also important to note that when a person has diabetes, episodes of stress, like a viral infection, can increase blood sugar levels, which can also lead to complications.”

Everyone should be taking precautionary measures during the COVID-19 outbreak (whether they have preexisting health conditions or not), and the IDF says it’s even more crucial for those living with diabetes. That means washing your hands thoroughly and frequently, avoiding touching your face as much as possible, cleaning and disinfecting frequently touched surfaces, and avoiding close contact with those showing symptoms of a respiratory illness.

The IDF also recommends additional precautionary steps for those with diabetes. Monitoring blood glucose levels should be a priority, because any kind of infection can raise blood sugar levels. This increases the need for water, so it’s important to have an adequate supply. To prepare for a quarantine, make sure you have enough medication, testing supplies, and food to last for at least a month. 

People with diabetes should be particularly careful about social contact. “As a diabetic, I would avoid supermarkets or other public gatherings,” Dr. Pena said. 

COVID-19 doesn’t only affect people with pre-existing physical conditions—it can have a serious impact on those with mental health issues, like anxiety and depression, even if you are not infected with the coronavirus.

“Fear of the virus and all the changes it’s causing are driving anxiety levels up for everyone, but for people who have an anxiety disorder it’s so much worse,” Gail Saltz, MD, associate professor of psychiatry at the NY Presbyterian Hospital Weill-Cornell School of medicine and host of the upcoming Personology podcast from iHeartRadio, tells Health. Dr. Saltz warns that people who have managed their disorder may relapse, and those actively struggling may be much more symptomatic. 

“Anxiety also worsens depression, particularly those whose depression is of the ‘agitated’ variety, a subtype of the illness characterized by jittery, anxious, irritable behavior,” she adds. 

People with anxiety or depression who are at home with someone who has COVID-19 may find the burden of caregiving to cause their mental health to deteriorate further. “Caregiving is very stressful,” says Dr. Saltz. “In many cases it’s a 24/7 role and for those already struggling, it can be overwhelming.” She adds that social distancing, quarantining, and losing the structure of work or school can also increase symptoms of both anxiety and depression by increasing feelings of loneliness. 

By actively focusing on mental health, however, those symptoms can be reduced. Dr. Saltz recommends exercising for 30 minutes each day and trying relaxation techniques like deep breathing and mindfulness to help keep anxiety at bay.

It’s also important to have structure in your day, even if you’re self-isolating or in quarantine, she says. This means getting up at the same time as you normally would, taking a shower, getting dressed, creating and sticking to a schedule, and maintaining normal sleep. If you work from home, make a dedicated workstation. 

If you need professional help, it’s still there for you even if you can’t get to the doctor’s office. “Most therapists are moving to online sessions to accommodate their patients,” says Dr. Saltz. If you take medication for your mental health, make sure you have a 30-day supply. 

Loneliness is an issue for people in all age groups, and even if you don’t have mental health issues yourself, you probably know someone who does. “Check in with those you know who are also self-isolating,” says Dr. Saltz says. “Talking to and supporting others is likely to make you feel better as well.” 

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless over-the-skin microcirculatory and nerve stimulant solution that has been validated to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

Doesn’t Your Health Deserve D’OXYVA?

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Non-Invasive Treatments: What No One Is Talking About

D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.

Sometimes it seems like the best way to guess a person’s age is by how much medicine they take daily. This system is not perfect, as some people start medications early in life, but we all seem to accumulate pills and creams as we age. That is why it can be a relief to discover an application that can be used for multiple health disorders. 

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Alexa, a 58-year-old woman from Texas, United States, has suffered from type 2 diabetes for more than 6 years. She has been taking multiple medications and treatments such as inhibitors, metformin, pain relievers and antibiotics for her diabetic foot wound. After discovering D’OXYVA, a non-invasive application that significantly helped with her pain and wound management after 5 weeks of twice-daily application, she shared that she saved so much when she started decreasing the intake of other medications and avoided a possible amputation just by using this non-invasive application.

D’OXYVA, for example, can be applied for a variety of conditions related to poor circulation. This multi-application product helps consumers save money, space, and time while simplifying everyday life.

Here are a few things about non-invasive treatments that people seem unwilling to discuss.

In layman’s terms, non-invasive treatments do not break the skin or enter beyond the surface of body openings. Invasive treatments include surgery and injections. Because the needles actually penetrate the skin, acupuncture is also considered an invasive procedure. Certain procedures may be considered minimally invasive if they do not penetrate deeply into the body or only require a small incision.

Non-invasive procedures include massage and gas delivery systems such as D’OXYVA.

By nature, an invasive procedure can be hazardous. Even under a doctor’s care, for example, minimally invasive surgical procedures carry risks (Mayo Clinic). Patients can experience unforeseen complications related to anesthesia, infections, or bleeding. While these risks are mitigated with less serious regular treatments, any invasive procedure carries the potential for infections or bleeding complications.

While you should always trust your medical professional’s advice, many non-invasive treatments can be safer. Most doctors will attempt to find the least invasive, most effective treatment.

Although the human body contains many different cells and functional systems, most of them share the same basic processes. For example, every cell in the body depends on a healthy circulation system to receive nutrients and oxygen. Therefore, when a person has circulation problems, it can manifest as a number of issues. Your doctor may be able to recommend one product like D’OXYVA for multiple circulation-related issues.

Examples of Circulation Related Issues

  • Slow-healing wounds, especially those related to diabetes or other cardiovascular issues
  • Septic shock related to a severe infection or a compromised immune system
  • Many forms of chronic pain
  • Varicose veins and other blemishes

 

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless over-the-skin microcirculatory and nerve stimulant solution that has been validated to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

If you suffer from symptoms related to poor circulation, you may not need to suffer in silence.

        BUY D’OXYVA

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Disorders of Microcirculation – Prevention and Treatment

D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.

Microcirculation[1] involves the smallest branching blood vessels in the body, which are the arterioles, the venules and the capillaries. These tiny blood vessels provide essential perfusion to the tissues of the body and supply oxygen while carrying away toxic metabolic waste products. Disorders of microcirculation can affect all end organs of the body, such as through the cardiovascular system, the central nervous system, peripheral circulation to the lower extremities and blood flow to the eyes and to the kidneys. The following case study involves a patient with multiple disorders of microcirculation that were all improved by application with D’OXYVA[2]

Arnie F was a 64-year-old white male with a long history of uncontrolled type 2 diabetes mellitus for the last 13 years, hypertension, depression, cardiovascular disease and kidney disease.

Due to his uncontrolled diabetes mellitus, Arnie had developed peripheral neuropathy and 2 large non healing ulcers[3] over the malleolar areas on both feet and over the soles of both feet.

These ulcers had never completely healed over a 9-year period.

Arnie also reported severe pain in his legs and calves most nights, with a self-reported score of 7 out of a possible 10 on the visual pain scale.

On physical exam, Arnie had a blood pressure of 140/95 and a body mass index of 26.

He also had diminished pedal pulses on both feet along with 2+ edema of both lower extremities.

After application with D’OXYVA, which is a deoxyhemoglobin transdermal vasodilator, for 5 minutes twice a day for 25 days, Arnie’s previously non-healing foot ulcers were nearly completely healed and he avoided the need for amputation.

In addition, Arnie’s leg and foot pain was eliminated after 4 weeks of D’OXYVA, and his depression lifted without additional medications.

Finally, Arnie’s exertional chest pain, which was due to his cardiovascular disease,[4] was also relieved and he was now able to walk 2 blocks without shortness of breath or chest pain.

Common Conditions Caused by Impaired Microcirculation

There are a number of common conditions caused by defects in microcirculation. These include the following:

  • Non-healing diabetic foot ulcers
  • Depression
  • Chronic pain from diabetic neuropathy
  • Chronic pain from fibromyalgia
  • Chronic pain from chronic wounds
  • Chronic pain from degenerative arthritis
  • Chronic pain from rheumatoid arthritis
  • Chronic pain from osteoporosis
  • Chronic pain from migraine headaches
  • Chronic lower back pain
  • Cardiovascular diseases such as ischemic heart disease and hypertension
  • Obesity
  • Insulin resistance
  • Type 2 diabetes mellitus
  • Chronic renal failure
  • Peripheral vascular disease
  • Venous insufficiency
Conclusion

Disorders of microcirculation[5] affect many different organs and systems of the body including the cardiovascular system, the peripheral vascular system and the central nervous system. D’OXYVA has been shown to be an effective application in  many conditions such as nonhealing wounds of the lower extremities and depression and in increasing strength and endurance in patients with cardiovascular diseases.

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless over-the-skin microcirculatory solution that has been validated to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

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Detecting Sepsis Early

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Estimates suggest that more than 30 million people worldwide are affected by sepsis each year, with up to six million of these dying from the condition. While vulnerable populations such as the very young, elderly, pregnant women and immunocompromised people are most at risk, sepsis can strike anyone suffering from an infection. Rapid and accurate detection of sepsis is critical to help limit the extent of tissue and organ dysfunction and damage that sepsis can cause.

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We recently spoke to Elena Sukhacheva, Director Medical and Scientific Affairs at Beckman Coulter, to learn about some of the challenges of diagnosing sepsis early, and how measuring Monocyte Distribution Width can be used as a sepsis biomarker to aid the process.

Anna MacDonald (AM): Why is early detection of sepsis so critical?

Elena Sukhacheva (ES): Sepsis is one of the most deadly and costly medical conditions physicians and hospitals must face. In fact, statistics show that sepsis is the third leading cause of death in the U.S.1. Mortality rates for sepsis is extremely high – approximately 25-30%—with more individuals dying of sepsis than prostate cancer, breast cancer, and HIV combined 2,3. Hospitalizations due to sepsis cost the healthcare system more than any other condition in the U.S.,4 with a total annual cost greater than 24 billion dollars5.

According to data from the Healthcare Cost and Utilisation Project (HCUP), there was an increase both in the number of cases of sepsis, and the costs associated with sepsis between 2000 and 20097. With sepsis as their primary diagnosis, the mean length of a patient’s hospital stay was close to nine days in 2009, with an average cost per entire stay at $18,500 7.

Early detection of sepsis is critical, as a delay in antibiotic treatment has been documented to result in increased mortality, with a 7.6% increase in death for patients with severe sepsis and septic shock every hour antibiotic administration is delayed8. Therefore, the earlier sepsis is recognized and the earlier the treatment starts, the better the outcome for the patient and the lower the cost that can be expected to be borne by the healthcare system.

AM: What are some of the challenges of rapidly diagnosing sepsis?

ES: The main challenge of timely diagnosis is that sepsis may manifest in dramatically different ways. Sepsis may affect anyone. For example, a young patient acquiring an infection from an appendectomy, for whom a dysregulated immune response leads to organ failure and death, or a patient undergoing aggressive cancer treatments, whose immune system is unable to fight infection due to immunosuppression. In both cases, the diagnosis would be “sepsis”, but symptoms in these two patients might look very different.

It is also important to mention that most (two-thirds) of patients diagnosed with sepsis enter the healthcare system through A&E9. Therefore, it is very important to ensure that efficient sepsis detection practices are used at this entry point. Symptoms are not always clear, so in practice, clinicians only order a test for sepsis when symptoms become clearer in the patient and they are more obviously septic. This delay in the diagnosis and treatment for patients with ambiguous presentation often results in a worse outcome10.

AM: How is sepsis currently diagnosed? What are the limitations of these methods and markers? 


ES: 
Before we talk about diagnosing sepsis, let’s define what sepsis is. As you may know, for many years we had the so-called sepsis-2 definition, which was introduced in 199214. That definition of sepsis was based on the presence of at least 2 SIRS criteria (systemic inflammatory response syndrome) and either a clinically suspected or proven infection. In 2016, a new definition was established for sepsis, and today, sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection15. Deaths from sepsis result, not from the infection itself, but from dysregulated immunity and organ dysfunction, which makes it impossible to efficiently fight against the infection.

Practically speaking, clinicians may use SIRS criteria (if they are still using sepsis-2) or the SOFA score (sequential organ failure assessment, if they use the sepsis-3 definition) to diagnose sepsis. Additionally, laboratory tests are used to test for infection and help confirm a suspicion of sepsis; for example by measuring the patient’s WBC (white blood cell) count, Procalcitonin, C-Reactive Protein, Interleukin-6 or presepsin levels, or culturing body fluids such as blood or urine for infectious organisms. While positive cultures may be diagnostic of infection, none of these tests can definitively confirm a diagnosis of sepsis, so clinicians must rely on all the clinical and laboratory information available together to diagnose sepsis.

Additionally, it is important to note that not all tests are routinely performed for all patients, but only ordered when a clinician suspects infection or sepsis. Therefore, diagnosing sepsis early is very challenging, because symptoms may not be obvious and clear at the time at which the patient presents at the hospital.

AM: Can you tell us more about the Early Sepsis Indicator?

ES: The Early Sepsis Indicator is the only FDA-cleared hematologic biomarker that is available to be automatically reported as part of a complete blood count (CBC) with differential test for adults entering through the A&E or emergency department. The new sepsis biomarker is available exclusively on the Beckman Coulter hematology analyzer, DxH 900. The parameter, Monocyte Distribution Width (MDW), is based on morphological changes in monocytes in response to infection. Since the Early Sepsis Indicator is included as part of a CBC-Diff analysis, it does not require additional blood to be drawn or a special order, and it is automatically reported for all adult patients.

Two scientific papers have already demonstrated the analytical performance of the Early Sepsis Indicator. The first results about early sepsis detection in ED with Monocyte Distribution Width were published in the journal, Chest in 201719. This study, which was conducted by Ohio State University, demonstrated that an elevated MDW value was able to discriminate sepsis from non-sepsis (according to sepsis-2 criteria) with a Receiver-Operator Curve Area Under the Curve (AUC) of 0.79, 77% sensitivity and 73% specificity. The study also analyzed the performance of the WBC count and the combination of WBC and MDW. When MDW and WBC values were combined, they produced an AUC of 0.89, which was significantly higher than the AUC for each individual parameter [WBC AUC was 0.74].

Another study published in Critical Care Medicine included more than 2,100 consecutive adult emergency-department patients, and was conducted in three U.S. University Hospitals. This clinical trial confirmed the discriminatory capacity of MDW alone, and MDW with WBC20.

AM: What role do monocytes play in the development of sepsis? What are the benefits of using Monocyte Distribution Width as a sepsis biomarker?

ES: Monocytes are cells of the innate immune system. They are closely involved in two key events in sepsis pathogenesis, the cytokine storm and sepsis-induced immunosuppression.

Three main cytokines that contribute to a cytokine storm are Tumor Necrosis Factor-alpha, Interleukin 1-beta and Interleukin-6. They are produced mainly by monocytes and macrophages. Interestingly, one monocyte subtype, the so-called “classic” monocytes, are able to further differentiate into macrophages in response to infection and contribute to cytokine production. IL-1 beta is the main initiator of the cascade of cytokines, TNF-a and IL-6 induce production of acute phase proteins and activate other immune cells. Production of these inflammatory cytokines and mediators by monocytes/macrophages contribute to the efficient growth control and dissemination of invading pathogens. However, excessive and uncontrolled production of these inflammatory cytokines and mediators may lead to serious systemic complications including microcirculatory dysfunction, liver and kidney damage, and septic shock with high mortality rates.

The second main factor contributing to the high mortality rate of patients diagnosed with sepsis is sepsis-induced immunosuppression. Immunosuppression of innate immunity in sepsis will manifest as chronic inflammation, decreased pro-inflammatory cytokine production, increased anti-inflammatory cytokine production, reduced phagocytosis, and contracted antigen presentation.

If we look at monocytes, these cells in septic patients can be very heterogeneous. Recent research has demonstrated that monocytes in the course of sepsis can be polarised from a pro-inflammatory state to an immunosuppressive state21. We hypothesize that this increased functional heterogeneity of monocytes in sepsis probably results in increased morphological variability, which is measured as MDW. An MDW value above the FDA-cleared cut off indicates an increased probability that the patient has sepsis or will develop sepsis within 12 hours of the ED encounter.

The benefits of using the Early Sepsis Indicator include that it is reported automatically with a CBC-Diff analysis, results of which are very quickly returned to the physician; The test takes less than a minute, it requires no extra blood to be drawn, and there is no need to order the test, making it a powerful and convenient tool that clinicians can use to alert them that a patient may have sepsis or develop sepsis within 12 hours of presentation at A&E. Taken together with the WBC count, which is also part of a CBC-Diff analysis, along with other laboratory findings and clinical information, the Early Sepsis Indicator provides a qualitative assessment of sepsis risk from a single whole-blood venous sample22.

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless over-the-skin microcirculatory solution that has been clinically tested to significantly improve microcirculation.

D’OXYVA works to prevent sepsis, and resulting septic shock, using life-restoring molecule carbon dioxide (CO₂) and gentle vapor dissolved across the skin in a fast, painless, handheld  5-minute application — performed either in a clinical setting or in the comfort and privacy of your own home.

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Why Good Blood Circulation Is Important for Overall Health

D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.

Proper blood circulation is the most important function of the human body, and it can play a very big role in one’s overall health. One of the vital components of the body, which is involved in this function, is the heart.

People often underestimate the important role of lifestyle choices on blood circulation, which can be significantly hindered by those choices. The following can negatively affect blood circulation:

  • Smoking
  • Not doing regular physical exercise
  • Leaving blood clots untreated
  • Having certain illnesses like heart diseases or diabetes

Patients suffering from poor blood circulation issues must consult Circularity Healthcare for advice and treatment.

The following are ways that blood circulation can impact a person’s health:

Benefits of good blood circulation

The following are a few benefits of good blood circulation:

  1. The body can maintain healthy oxygen and blood flow, which will allow the heart, lungs and muscles to function properly and efficiently.
  2. The body can avoid and fight diseases and sicknesses. In addition, white blood cells in the immune system can be transported around the body as needed.
  3. The organs will remain in proper working order and help remove waste from the body.

Risks of poor blood circulation

The following are a few effects of having poor blood circulation:

  1. One may feel a lack of energy, inability to concentrate and excessive tiredness.
  2. Limited oxygen flow to the brain can cause memory glitches.
  3. Women may suffer from hair loss or alopecia.
  4. Men may suffer from erectile dysfunction.
  5. Sores and cuts may take much longer to heal.
  6. Poor blood circulation may cause amputation of the affected limb.

 

How can one improve circulation?

To improve blood circulation, a person needs to make a few lifestyle changes. The following tips can help:

  1. Doing yoga involves the stretching and bending of the body to different postures for a certain duration. In the beginning, it may be little difficult, but soon with regular practice, one can achieve the desired results.
  2. Massages can be another great way of relaxing and unwinding. This can also help in bonding well with a partner.
  3. Engaging in certain cardiovascular exercises can help one maintain a healthy weight and can improve blood circulation.
  4. It is also important to keep the body well hydrated by drinking enough liquids, including water, to flush out all the toxins present in the blood.
  5. Many people are not aware that eating seafood can also improve blood circulation because of the omega-3 fatty acids it contains. A few of the healthiest choices are salmon, tuna, mackerel and sardines.

People suffering from poor blood circulation always risk getting blood clots and must contact a physician or healthcare professional for proper advice on improving blood circulation.

      BUY D’OXYVA

HOW D’OXYVA CAN HELP?

D’OXYVA (deoxyhemoglobin vasodilator) is the first of its kind biotech solution. D’OXYVA has been clinically validated for a variety of significant and rare health, athletic, and cosmetic benefits with record time and cost savings. The FDA-cleared medical CO2 and gentle vapor dissolves in a molecular form in the skin to improve skin perfusion pressure or blood circulation.

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Cause of sepsis-induced lung injury

D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.

A KAIST research team succeeded in visualizing pulmonary microcirculation and circulating cells in vivo with a custom-built 3D intravital lung microscopic imaging system. They found a type of leukocyte called neutrophils aggregate inside the capillaries during sepsis-induced acute lung injury (ALI), leading to disturbances and dead space in blood microcirculation. According to the researchers, this phenomenon is responsible for tissue hypoxia causing lung damage in the sepsis model, and mitigating neutrophils improves microcirculation as well as hypoxia.

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According to the researchers, this phenomenon is responsible for tissue hypoxia causing lung damage in the sepsis model, and mitigating neutrophils improves microcirculation as well as hypoxia.

The lungs are responsible for exchanging oxygen with carbon dioxide gases during the breathing process, providing an essential function for sustaining life. This gas exchange occurs in the alveoli, each surrounded by many capillaries containing the circulating red blood cells.

Researchers have been making efforts to observe microcirculation in alveoli, but it has been technically challenging to capture high-resolution images of capillaries and red blood cells inside the lungs that are in constant breathing motion.

Professor Pilhan Kim from the Graduate School of Medical Science and Engineering and his team developed an ultra-fast laser scanning confocal microscope and an imaging chamber that could minimize the movement of a lung while preserving its respiratory state. They used this technology to successfully capture red blood cell circulation inside the capillaries of animal models with sepsis.

During the process, they found that hypoxia was induced by the increase of dead space inside the lungs of a sepsis model, a space where red blood cells do not circulate. This phenomenon is due to the neutrophils aggregating and trapping inside the capillaries and the arterioles. It was also shown that trapped neutrophils damage the lung tissue in the sepsis model by inhibiting microcirculation as well as releasing reactive oxygen species.

Further studies showed that the aggregated neutrophils inside pulmonary vessels exhibit a higher expression of the Mac-1 receptor (CD11b/CD18), which is a receptor involved in intercellular adhesion, compared to the neutrophils that normally circulate. Additionally, they confirmed that Mac-1 inhibitors can improve inhibited microcirculation, ameliorate hypoxia, while reducing pulmonary edema in the sepsis model.

Their high-resolution 3D intravital microscope technology allows the real-time imaging of living cells inside the lungs. This work is expected to be used in research on various lung diseases, including sepsis.

The research team’s pulmonary circulation imaging and precise analytical techniques will be used as the base technology for developing new diagnostic technologies, evaluating new therapeutic agents for various diseases related to microcirculation.

Professor Kim said, “In the ALI model, the inhibition of pulmonary microcirculation occurs due to neutrophils. By controlling this effect and improving microcirculation, it is possible to eliminate hypoxia and pulmonary edema — a new, effective strategy for treating patients with sepsis.”

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless over-the-skin microcirculatory solution that has been clinically tested to significantly improve microcirculation.

D’OXYVA works to prevent sepsis, and resulting septic shock, using life-restoring molecule carbon dioxide (CO₂) and gentle vapor dissolved across the skin in a fast, painless, handheld  5-minute application — performed either in a clinical setting or in the comfort and privacy of your own home.

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7 Subtle Signs That Prove You’re Not As Healthy As You Think You Are

D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.

When you say healthy, it often brings to mind an image of person that exercises all the time and only eats nutritious food while avoiding junk like candy and fast food. However, it actually demands so much more than that. Truth is, being truly healthy means that one should have a sense of “physical, mental, and social wellbeing, and the resources to live a full life.”

Of course, we don’t always think of it that way. In fact, in most cases, eating healthy and pairing it with consistent exercise is more than enough. However, while being classified as “overweight” or “underweight” is an obvious sign of being unhealthy, there are also other not-so-obvious signs — ones that you may be ignoring. And ones that may mean you’re not as healthy as you believe you are. Below are some of them.

  1. Snoring – You may think it’s just an embarrassing act, but it can also indicate that you’re not that healthy. In fact, snoring is linked to a variety of health conditions, including sleep apnea, heart disease, and even stroke.
  2. Constant skin breakouts – Skin breakouts are also a sign of general unhealthiness, and unfortunately, there’s no single cause. However, thanks to face mapping, we can now easily adjust our lifestyle based on where we get breakouts. Chin acne for example, means we have to eat healthier, while forehead acne means we need better sleep and hygiene.
  3. The white of your eyes aren’t as white – This one is more subtle, but basically, if your eyes are a tad yellowish, it indicates that you may have complications in your bile ducts, gall bladder, liver or pancreas. There’s also red eyes, which come from lack of sleep and exhaustion.
  4. Your nails have an odd color and texture – A yellowish color in your nails is believed to be caused by fluid build-up and inadequate circulation in the body.
  5. Being gassy – Excessive gas can be signs of an irritable bowel syndrome, lactose intolerance, and celiac disease.
  6. Constant exhaustion – This one is obvious, but continuous exhaustion means that you may have iron deficiency, too little exercise, and even dehydration.
  7. Your urine doesn’t have a pale color – The color, smell, and density of urine can reveal what’s going on in our body. And in this case, having urine that has a darker color or has a strong scent means that you should probably get yourself checked by a doctor ASAP.

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been clinically tested to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

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Did you know when used in a regimen, D`OXYVA users have reported a number of health and beauty benefits?

doxyva benefits

OPTIMIZE BLOOD CIRCULATION FOR A WIDE VARIETY OF SIGNIFICANT OUTCOMES

D’OXYVA® (deoxyhemoglobin vasodilator) in various clinical trials has validated leading independent research results and demonstrated above-average results in improving a host of physiological functions at the same time.

People using D’OXYVA® have recorded significant improvements in cardiovascular activity leading to much improved physical activity. As part of a healthy lifestyle, D’OXYVA may help significantly reduce the risk of high blood pressure, hypertension, cholesterol, and diabetes in just two or three months, with an average use of 5 minutes a day and 5 times a week.

Poor circulation is a gateway for a litany of ailments: slow healing, depression, poor complexion, sores, slow metabolism, and more.

D’OXYVA significantly improves sustained oxygen-rich microcirculatory blood flow locally and throughout the body. Its patented method of fully non-invasive, painless, and harmless transdermal delivery is unique only to D’OXYVA.

When used daily, D’OXYVA users have reported a number of health and beauty benefits, including but not limited to:

  • Relief from symptoms of microvascular complications
  • Significantly increased cardiac function, physical fitness, endurance and strength, muscle size, body tone, faster recovery from sports injuries and surgical trauma
  • Improved self-esteem via promoting healthy and radiant skin, complexion, dry skin relief, and acne reduction
  • Significant reduction in downtime from other skin treatments and cosmetic procedures when used in combination, reduction in the appearance of scars, cellulite, fat, spider veins and stretch marks
  • Promoting and maintaining a healthy weight, improving general mobility, deeper, more restful sleep
  • Significant improvement of mental acuity; concentration, problem solving, multitasking, eye-hand coordination, heightened stamina, energy, and focus while managing stress
  • Improved vitals across the board during checkups with zero adverse event reports after years of regular use by people with various health, demographic, and ethnic backgrounds

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been clinically tested to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

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The Microcirculation in Sepsis

Deterioration of the Microcirculation in Diabetes

Sepsis is a leading cause of mortality in critically ill patients. The pathophysiology of sepsis involves a highly complex and integrated response, including the activation of various cell types, inflammatory mediators, and the haemostatic system.

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Recent evidence suggests an emerging role of the microcirculation in sepsis, necessitating a shift in our locus away Irom the macrohaemodynamics to ill icrohaemodynanmics in a septic patient. This review article provides a brief overview of the microcirculation, its assessment techniques, and specific therapies to resuscitate the microhaemodynamics.

Introduction

Sepsis and its progression to severe sepsis, septic shock and multiple organ dysfunction syndrome is a major cause of ICU admissions and mortality. Severe sepsis and septic shock may be characterized by a derangement in global cardiac indices typically leading to low peripheral resistance, which the body tries to compensate for by increasing the cardiac output. However, despite this increase in cardiac output, the tissues are unable to utilize oxygen as evidenced by the high lactate levels, deranged acid-base balance, and increased gastric carbon dioxide level. The presence of tissue hypoxia despite adequate systemic oxygen transport has been blamed on altered microhaemodynamics as well as in mitochondrial dysfunction during sepsis. However, the relative contributions of disturbed microcirculation and impaired mitochondrial function for sepsis related tissue dysoxia are still debatable. The present review aims to highlight the former cause of tissue hypoxia in sepsis i.e., involvement of the microcirculation. It moves from recapitulating relevant anatomy of microcirculation, to its current role in pathophysiology of sepsis, optimization during sepsis and lastly the modalities for its assessment.

Microcirculatory perfusion as an endpoint

Much of the research pertaining to resuscitation during sepsis has focused on restoring the macrodynamics of circulation such as blood pressure, oxygen delivery and oxygen extraction ratio. The pathologic shunting occurring in the microcirculation is not depicted by systemic haemodynamic derived and oxygen derived variables. The difference between macrocirculation and microcirculation was recognized very early on when it was pointed that changes in total peripheral resistance could not provide information regarding local vascular resistance changes since “dilation in one vascular bed may be accompanied by constriction elsewhere”. Also, the cause of alterations in the macrohaemodynamics lies in the microcirculation e.g., the decrease in systemic vascular resistance and hypotension result from arteriolar vasodilatation and hypovolemia from capillary leak. Thus, it needs to be answered whether resuscitating the microcirculation rather than the macrocirculation will finally answer the quest for improving survival in sepsis.

There is previous evidence that resuscitating the macrohaemodynamics is not always associated with improved microhaemodynamics, organ function, or survival. A study by LeDoux and colleagues observed the effect of norepinephrine on global haemodynamic parameters and measures of tissue oxygenation during septic shock. While the mean blood pressure increased from 65 to 85 mmHg along with expected increase in heart rate and cardiac index (p<0.05), there was no improvement in organ function or tissue oxygenation as evidenced by decrease in urine output, no change in capillary red blood cell velocity, fall in capillary blood flow and increase in gastric pCO2. The authors thus concluded that resuscitation of mean blood pressure or cardiac output alone in septic shock is inadequate. Microcirculatory independence from arterial blood pressure in septic shock has also been proven using direct imaging of microcirculation,. DeBacker et al reported a significant decrease in vessel density and proportion of small perfused vessels in septic patients, the alterations being more severe in non-survivors and were not related to the mean arterial pressure. Sakr and colleagues further explored these findings by studying the microcirculation in 49 septic patients. The small vessel perfusion was seen to improve rapidly in survivors as compared to non-survivors, with no difference in the global haemodynamic variables. Together with the evidence showing that organ function improves and mortality decreases when resuscitation boosts microcirculatory flow, the microcirculation does appear to be a new target for resuscitation during sepsis.

Assessment of microcirculation

Till date, there is no single objective gold standard to assess the microcirculation. In clinical practice, microcirculatory perfusion has been traditionally judged by the color, capillary refill and temperature of the distal parts of the body (i.e., finger, toes, earlobes and nose). Amongst the investigational modalities available to assess microcirculation, both indirect indicators as well as direct techniques exist, even though any single objective reliable method is still not recognized. Indirect techniques involve measurement of ‘downstream’ global derivatives of microcirculatory dysfunction such as lactate, carbon dioxide, and oxygen saturation. The direct imaging of microcirculatory perfusion seems a superior approach to assessment of microcirculation. Invention of microscope is perhaps the single most important advancement in technology linked to discovering the microcirculation, since experimental investigation of the microcirculation began soon after its advent. Studies of human microcirculation began at the end of 19th century, with Hueter using a microscope with reflected light to investigate vessels on inner border of lower lip.

Future aspects

With several clinical and laboratory indicators of identifying hypoperfusion due to the microcirculation dysfunction being available, it is perhaps time to recognize shock in sepsis keeping tissue hypoperfusion as distinct from hypotension. A perfusion based scoring system has been proposed by Spronk et al. It emphasizes the need of extending recognition of shock severity to include microcirculatory parameters, besides global haemodynamic and oxygen-derived parameters.

Therapy in shock should be aimed at optimizing cardiac function, arterial hemoglobin saturation, and tissue perfusion. This not only includes correction of hypovolemia, but the restoration of an evenly distributed microcirculatory flow and adequate oxygen transport as well. The role of vasodilators in recruiting the microcirculation will need to be looked into further.

Direct monitoring of sublingual microcirculation monitoring appears to be a promising endpoint for resuscitating the microcirculation. An integrative approach incorporating both macrocirculatory and microcirculatory haemodynamic data may indeed hold the answer to resuscitation in sepsis.

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless over-the-skin microcirculatory solution that has been validated to significantly improve microcirculation.

D’OXYVA works to prevent sepsis, and resulting septic shock, using life-restoring molecule carbon dioxide (CO₂) and gentle vapor dissolved across the skin in a fast, painless, handheld  5-minute application — performed either in a clinical setting or in the comfort and privacy of your own home.