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Disorders of Microcirculation – Prevention and Treatment

D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.

Microcirculation[1] involves the smallest branching blood vessels in the body, which are the arterioles, the venules and the capillaries. These tiny blood vessels provide essential perfusion to the tissues of the body and supply oxygen while carrying away toxic metabolic waste products. Disorders of microcirculation can affect all end organs of the body, such as through the cardiovascular system, the central nervous system, peripheral circulation to the lower extremities and blood flow to the eyes and to the kidneys. The following case study involves a patient with multiple disorders of microcirculation that were all improved by application with D’OXYVA[2]

Arnie F was a 64-year-old white male with a long history of uncontrolled type 2 diabetes mellitus for the last 13 years, hypertension, depression, cardiovascular disease and kidney disease.

Due to his uncontrolled diabetes mellitus, Arnie had developed peripheral neuropathy and 2 large non healing ulcers[3] over the malleolar areas on both feet and over the soles of both feet.

These ulcers had never completely healed over a 9-year period.

Arnie also reported severe pain in his legs and calves most nights, with a self-reported score of 7 out of a possible 10 on the visual pain scale.

On physical exam, Arnie had a blood pressure of 140/95 and a body mass index of 26.

He also had diminished pedal pulses on both feet along with 2+ edema of both lower extremities.

After application with D’OXYVA, which is a deoxyhemoglobin transdermal vasodilator, for 5 minutes twice a day for 25 days, Arnie’s previously non-healing foot ulcers were nearly completely healed and he avoided the need for amputation.

In addition, Arnie’s leg and foot pain was eliminated after 4 weeks of D’OXYVA, and his depression lifted without additional medications.

Finally, Arnie’s exertional chest pain, which was due to his cardiovascular disease,[4] was also relieved and he was now able to walk 2 blocks without shortness of breath or chest pain.

Common Conditions Caused by Impaired Microcirculation

There are a number of common conditions caused by defects in microcirculation. These include the following:

  • Non-healing diabetic foot ulcers
  • Depression
  • Chronic pain from diabetic neuropathy
  • Chronic pain from fibromyalgia
  • Chronic pain from chronic wounds
  • Chronic pain from degenerative arthritis
  • Chronic pain from rheumatoid arthritis
  • Chronic pain from osteoporosis
  • Chronic pain from migraine headaches
  • Chronic lower back pain
  • Cardiovascular diseases such as ischemic heart disease and hypertension
  • Obesity
  • Insulin resistance
  • Type 2 diabetes mellitus
  • Chronic renal failure
  • Peripheral vascular disease
  • Venous insufficiency

Disorders of microcirculation[5] affect many different organs and systems of the body including the cardiovascular system, the peripheral vascular system and the central nervous system. D’OXYVA has been shown to be an effective application in  many conditions such as nonhealing wounds of the lower extremities and depression and in increasing strength and endurance in patients with cardiovascular diseases.


D’OXYVA is the only fully noninvasive, completely painless over-the-skin microcirculatory solution that has been validated to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

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Why Good Blood Circulation Is Important for Overall Health

D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.

Proper blood circulation is the most important function of the human body, and it can play a very big role in one’s overall health. One of the vital components of the body, which is involved in this function, is the heart.

People often underestimate the important role of lifestyle choices on blood circulation, which can be significantly hindered by those choices. The following can negatively affect blood circulation:

  • Smoking
  • Not doing regular physical exercise
  • Leaving blood clots untreated
  • Having certain illnesses like heart diseases or diabetes

Patients suffering from poor blood circulation issues must consult Circularity Healthcare for advice and treatment.

The following are ways that blood circulation can impact a person’s health:

Benefits of good blood circulation

The following are a few benefits of good blood circulation:

  1. The body can maintain healthy oxygen and blood flow, which will allow the heart, lungs and muscles to function properly and efficiently.
  2. The body can avoid and fight diseases and sicknesses. In addition, white blood cells in the immune system can be transported around the body as needed.
  3. The organs will remain in proper working order and help remove waste from the body.

Risks of poor blood circulation

The following are a few effects of having poor blood circulation:

  1. One may feel a lack of energy, inability to concentrate and excessive tiredness.
  2. Limited oxygen flow to the brain can cause memory glitches.
  3. Women may suffer from hair loss or alopecia.
  4. Men may suffer from erectile dysfunction.
  5. Sores and cuts may take much longer to heal.
  6. Poor blood circulation may cause amputation of the affected limb.


How can one improve circulation?

To improve blood circulation, a person needs to make a few lifestyle changes. The following tips can help:

  1. Doing yoga involves the stretching and bending of the body to different postures for a certain duration. In the beginning, it may be little difficult, but soon with regular practice, one can achieve the desired results.
  2. Massages can be another great way of relaxing and unwinding. This can also help in bonding well with a partner.
  3. Engaging in certain cardiovascular exercises can help one maintain a healthy weight and can improve blood circulation.
  4. It is also important to keep the body well hydrated by drinking enough liquids, including water, to flush out all the toxins present in the blood.
  5. Many people are not aware that eating seafood can also improve blood circulation because of the omega-3 fatty acids it contains. A few of the healthiest choices are salmon, tuna, mackerel and sardines.

People suffering from poor blood circulation always risk getting blood clots and must contact a physician or healthcare professional for proper advice on improving blood circulation.



D’OXYVA (deoxyhemoglobin vasodilator) is the first of its kind biotech solution. D’OXYVA has been clinically validated for a variety of significant and rare health, athletic, and cosmetic benefits with record time and cost savings. The FDA-cleared medical CO2 and gentle vapor dissolves in a molecular form in the skin to improve skin perfusion pressure or blood circulation.

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Did you know when used in a regimen, D`OXYVA users have reported a number of health and beauty benefits?

doxyva benefits


D’OXYVA® (deoxyhemoglobin vasodilator) in various clinical trials has validated leading independent research results and demonstrated above-average results in improving a host of physiological functions at the same time.

People using D’OXYVA® have recorded significant improvements in cardiovascular activity leading to much improved physical activity. As part of a healthy lifestyle, D’OXYVA may help significantly reduce the risk of high blood pressure, hypertension, cholesterol, and diabetes in just two or three months, with an average use of 5 minutes a day and 5 times a week.

Poor circulation is a gateway for a litany of ailments: slow healing, depression, poor complexion, sores, slow metabolism, and more.

D’OXYVA significantly improves sustained oxygen-rich microcirculatory blood flow locally and throughout the body. Its patented method of fully non-invasive, painless, and harmless transdermal delivery is unique only to D’OXYVA.

When used daily, D’OXYVA users have reported a number of health and beauty benefits, including but not limited to:

  • Relief from symptoms of microvascular complications
  • Significantly increased cardiac function, physical fitness, endurance and strength, muscle size, body tone, faster recovery from sports injuries and surgical trauma
  • Improved self-esteem via promoting healthy and radiant skin, complexion, dry skin relief, and acne reduction
  • Significant reduction in downtime from other skin treatments and cosmetic procedures when used in combination, reduction in the appearance of scars, cellulite, fat, spider veins and stretch marks
  • Promoting and maintaining a healthy weight, improving general mobility, deeper, more restful sleep
  • Significant improvement of mental acuity; concentration, problem solving, multitasking, eye-hand coordination, heightened stamina, energy, and focus while managing stress
  • Improved vitals across the board during checkups with zero adverse event reports after years of regular use by people with various health, demographic, and ethnic backgrounds


D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been clinically tested to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

Reduce unwanted doctor visits, recommended and ranked top by experts!

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Can Oxygen Therapy Improve Brain Blood Vessel Function in COPD Patients?

D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.

By Allison Inserro

Breathing in additional oxygen improves the function of blood vessels in the brains of people with chronic obstructive pulmonary disease (COPD), according to research published in Experimental Physiology.

The study revealed that patients with COPD are at higher risk of dementia, possibly because of lower brain oxygen levels as a result of problems with blood supply from brain blood vessels. According to other research cited in the study, giving patients with COPD additional oxygen reduced their risk of developing dementia, but the mechanisms underlying this effect had not been explored.

The latest research aimed to establish the effect of supplying additional oxygen in blood flow to the brain and blood vessel function in patients with COPD. Fourteen hypoxemia patients were included in the study, which tracked cerebral blood flow (CBF), oxygen delivery (CDO2), and neurovascular coupling (NVC), which is the relationship between local neuron activity and changes in CBF.

The researchers used ultrasound to view and measure blood flow in the brain in these patients at rest as well as before and during delivery of the additional oxygen. Ultrasound was used to measure the extent to which brain blood flow increased.

Participants began this test with their eyes shut, then opened them and read a piece of text. This test was designed to increase activity in the brain, and brain blood flow was expected to increase to provide an adequate oxygen supply.

Pairing these ultrasound measures with a measurement of blood oxygen levels allowed authors to estimate how much oxygen delivery to the brain increased during the eyes-open reading test.

Measurements were assessed, and the authors found that blood flow and oxygen delivery to the brain significantly increased during reading because blood vessels in the brain dilated in response to the greater oxygen demand when the brain was active.

Specifically, peripheral oxyhemoglobin saturation increased from 91 ± 3.3 to 97.4 ± 3% (P <.01). CBF was unaltered (593.0 ± 162.8 vs 590.1 ± 138.5 mL min−1; P = .91) with supplemental O2.

However, CDO22 (98.1 ± 25.7 versus 108.7 ± 28.4 ml dl−1; P = 0.02) and NVC improved.

The posterior cerebral artery cerebrovascular conductance increased after O2 normalization (+40%, from 20.4 ± 9.9 to 28 ± 10.4% increase in conductance; P = .04). The posterior cerebral artery cerebrovascular resistance decreased to a greater extent during O2 normalization (+22%, from −16.7 ± 7.3 to −21.4 ± 6.6% decrease in resistance; P = .04).

The cerebral vasculature of patients with COPD appears insensitive to oxygen because CBF was unaltered in response to O2 supplementation, leading to improved CDO2.

Providing extra oxygen to patients with COPD improved the function of blood vessels in the brain by increasing blood supply to meet the demands of the brain’s activity during this short test.

Other research is needed to see how long-term oxygen use would impact the function of brain blood vessels.

These improvements might provide a physiological link between oxygen therapy and a reduced risk of cerebrovascular diseases such as stroke, mild cognitive impairment, and dementia.


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Being mindful of symptoms

D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.

LEWISTOWN–Dr. Maya Lichtenstein, neurologist at Geisinger-Lewistown Hospital, said that there are a myriad of potential symptoms that could be signs of a stroke. “Any sudden changes,” said Lichtenstein, “go the E.R.”

A stroke, according to Liechtenstein, is either the result of not enough blood flow to the brain, plaque in the blood vessels or heart, each resulting in a clot, or a hemorrhagic bleed, resulting in a burst blood vessel in the brain. Classic symptoms of a stroke include numbness, tingling, weakness on one side of the body and changes in speech, but other sudden changes in in understanding language, vision, vertigo or clumsiness can also be symptomatic.

“It depends on what part of the brain is damaged,” said Lichtenstein.

Treatment options for a stroke vary, depending on the type of stroke.

“If you get seen fast enough,” said Lichtenstein, for a clot, a “clot-busting medication, a form of blood thinner” can be administered via I.V. A thrombectomy, a procedure, not an operation, said Lichtenstein, is another treatment option, similar to a cardiac catheterization. A bleeding stroke often leads to lowering the patient’s blood pressure and surgically relieving pressure on the brain. Taking aspirin can also treat a stroke.

Post-stroke, Liechtenstein said that rehabilitation is important, including physical, occupational, speech, and cognitive therapies. “Aggressive therapy can continue to improve people’s symptoms,” said Lichtenstein. “Everyone thinks they’re better if they can move their arms and legs.” Lichtenstein also encourages stroke patients to be aware of their mood and possible depression, encouraging them to accept all the help available.

To avoid a stroke, Liechtenstein said patients should see their doctors regularly for preventive care and that leading a healthy lifestyle is the key, including regular exercise to keep up the heart rate and eating a diet rich in fresh fruit and vegetables, lean proteins and whole grains. Lichtenstein also encourages patients to keep control of their vascular issues, such as high blood pressure and diabetes, as well as to quit smoking, if they smoke.

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Looking into the eye of patients with chronic obstructive pulmonary disease

D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.

Chronic obstructive pulmonary disease (COPD) is a complex disease with many patients suffering from cardiovascular comorbidity. However, cardiovascular diseases remain often undiagnosed in COPD.

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Assessment of the retinal microvasculature can provide value in cardiovascular profiling of these patients. Retinal microvascular assessment carried out via a noninvasive eye exam represents an easy to use tool when examining patients with COPD. The purpose of this review was to provide an overview of studies assessing structural and functional changes in the retinal microvasculature of patients with COPD. Findings demonstrated that structural and functional microvascular changes were more common and severe in COPD patients as compared to non‐COPD controls, although few retinal investigations have been performed in patients with COPD. As cardiovascular comorbidities are highly prevalent in COPD, we advocate more research to investigate the value of an eye exam for microvascular phenotyping of COPD patients.

D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.
Noninvasive retinal analysis for cardiovascular profiling of patients with chronic obstructive pulmonary disease.

In addition, assessment of dynamic changes in retinal vessel diameter during flicker light stimulation can provide important functional information, as it is a measure of the vascular reactivity and reflects the endothelial function of the microcirculation (Heitmar & Summers 2012). Dysfunction of the endothelium, represented by a reduced flicker light‐induced vasodilatation, precedes the development of vascular changes, which can eventually result in cardiovascular events (Flammer et al. 2013). An impaired flicker light‐induced vasodilatation has already been demonstrated in patients with increased cardiovascular risk, such as diabetes, hypertension, obesity and dyslipidemia (Heitmar & Summers 2012; Lim et al. 2013). Furthermore, dynamic assessment of the orbital vessels, using colour Doppler ultrasonography, has demonstrated that changes in blood flow velocity and resistive index (RI), are associated with various vascular disorders, and have clinical importance for the prediction of coronary artery disease (Tranquart et al. 2003; Maruyoshi et al. 2010).

Structural and functional assessment of the vasculature of the eye is used in many epidemiological and clinical research settings and the aim of this paper is to bring together the information that is available on patients with COPD.


Structural and functional assessment of the vasculature of the eye has provided useful information in a myriad of epidemiological and clinical research settings, with the ability to provide value for cardiovascular risk prediction. Cardiovascular risk factors (e.g. hypertension, obesity, diabetes) are usually preceded by changes in the microvasculature. A substantial number of patients suffering from COPD have microvascular complications and are at risk for diabetes and cardiovascular diseases. Considering the utility of retinal imaging in other clinical domains, we suggest to also consider retinal imaging for better phenotyping COPD patients (Figure 1). However, our systematic analysis suggests that this field is largely unexplored, and longitudinal studies assessing the association between microvascular changes in the eye and enhanced cardiovascular risk in COPD are lacking.

We identified four different methods for structural and functional assessment of the vasculature of the eye: OCT, retinal fundus imaging, retinal oximetry or colour Doppler ultrasonography. Available data suggest the presence of structural and functional microvascular changes in eyes of patients with COPD, including increased retinal venular caliber, lower retinal arterial oxygen saturation, impaired hemodynamics and increased RI of the orbital vessels. Results on choroidal thickness are contradictory. Authors speculated that the changes in microvasculature are related to systemic inflammation and hypoxia in COPD. Indeed, both systemic inflammation and hypoxia play a role in the pathogenesis of cardiovascular diseases. We advocate studies focusing on the characterization of the retinal microvasculature in patients with COPD, including validation using echocardiography and electrocardiogram and repeated assessments to establish stability over time. Moreover, assessment during COPD exacerbations resulting in hospitalizations is of interest as these exacerbations are associated with an increased cardiovascular mortality. Considering the high prevalence and incidence of cardiovascular comorbidity in COPD patients, and the fact that cardiovascular comorbidities are often undiagnosed, retinal imaging techniques might be valuables tools for further cardiovascular phenotyping of patients with COPD, which may lead to better patient stratification and more individualized treatments.


D’OXYVA is the only fully noninvasive, completely painless over-the-skin microcirculatory solution that has been validated to significantly improve microcirculation.

D’OXYVA’s versatile, over-the-skin, non-toxic CO₂ and soothing vapor delivery system has the potential to dramatically improve microcirculation and the comprehensive function of developing lungs.

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8 Warning Signs of Poor Blood Circulation

D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.

Poor blood circulation is the start of numerous other ailments.

What causes poor blood circulation?

Low blood circulation is caused by different underlying conditions. The most common ones are atherosclerosis (“hardening of the arteries) and peripheral artery disease (PAD).

If you experience symptoms of blood circulation problems, consult your physician right away. Poor circulation can lead to heart attack, stroke and even death.

What are the signs of poor blood circulation?

Symptoms of poor blood circulation mostly occur in the hands, feet, arms, and legs. Here are 8 signs to look out for…

  1. Leg Pain While Walking

A common symptom of poor blood circulation is pain or cramping of your leg or hip muscles. This is felt while walking, climbing stairs or another similar physical activity. This is a condition called intermittent claudication, which is a sign of PAD.

  1. Numbness and Weakness

Your arms or legs may feel weak or numb. This can happen while you are moving, or even sitting still.

If these symptoms in your arms and legs come about suddenly and are accompanied by impaired or slurred speech and drooping facial muscles, you may have low blood circulation to your brain due to atherosclerosis.

Poor circulation in the arteries which supply blood to the brain can cause a stroke.

  1. Coldness and Swelling

If your feet, hands or lower legs feel cold all the time for no apparent reason – it is a sign of poor blood circulation.

Low blood circulation due to PAD or atherosclerosis tends to produce coldness in one foot, hand or leg more than the other. You could also notice swelling in your extremities due to poor circulation, particularly in your legs and feet.

  1. Non-healing Sores

Sores on your feet or legs that don’t seem to heal are a common sign. You may also notice that ulcers or infections in your legs and feet heal very slowly.

You may also notice that you’re losing hair on your legs and feet or that your hair is growing slower than normal. Your toenails may grow slowly as well.

  1. Changes in Skin Colour

Poor circulation can cause your skin in your arms, hands, legs and feet to change colour. You may notice that your skin looks “shiny”.

Your legs and feet may turn pale or bluish in colour, due to the poor blood and oxygen delivery to your extremities.

  1. Weak Pulse in Your Legs

Poor blood circulation due to atherosclerosis or PAD can cause your pulse to become weak in your feet or legs.

When the pulse in your limbs is weak or absent, this means that there is little or no blood circulation to these areas.

The most common method that doctors use to determine blood flow problems is to check your pulse in the leg and groin areas.

  1. Chest Pain

Chest pain or angina, and other symptoms of a heart attack are signs of poor blood circulation in the arteries to your heart.

This may be a sign of atherosclerosis in these arteries. If you have chest pain, you should see your doctor right away to prevent a potentially life-threatening medical problem.

  1. Erectile Dysfunction

If you’re a man, experiencing erectile dysfunction can be a sign of low blood circulation.

Erectile problems can indicate poor blood flow to your groin and lower extremities due to one or more blocked, clogged, or narrowed arteries.

D’OXYVA (deoxyhemoglobin vasodilator) delivers the highest possible concentration of CO2 and has been clinically studied to SIGNIFICANTLY INCREASE BLOOD FLOW volume in the microcirculatory system.

In short, based on current leading neurology, immunology, microvascular, and cellular oxygenation science, D’OXYVA is leading the field by quickly targeting to:

Significantly lower the risk of diabetes and cardiovascular complications

Provide complete healing of difficult wounds together with major pain relief and improved quality of life:

  • Detoxify the skin and body
  • Improve sleep
  • Stamina and skin health
  • Reduce inflammation
  • And much more for all kinds of people
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Impaired Hemorheology in Exacerbations of COPD

D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.

Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation. Cardiovascular-related comorbidities are established to contribute to morbidity and mortality especially during exacerbations. The aim of the current study was to determine alterations in hemorheology (erythrocyte aggregation, deformability) in newly diagnosed COPD patients and their response to medical treatment and to compare with values of COPD patients with exacerbations.

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Chronic obstructive pulmonary disease (COPD) is a common, preventable, and manageable disease process that is characterized by progressive persistent airflow restrictions and related to increased chronic inflammatory reaction of the airways and lungs against harmful gases and particles [1]. Exacerbations of COPD are defined as the worsening of symptoms such as increment of dyspnea, phlegm volume, and phlegm purulence, usually accompanied by hypoxia and hypercapnia [23]. The most common causes of COPD exacerbations are infections. Inflammation is an important component of the disease [4]. Macrophages and neutrophils play an important role in the inflammatory process [5]. On the other hand, RBC were proposed as biosensors for the stadium of COPD [6]. Nowadays, COPD treatment options include quitting smoking, pharmacological treatment (short-acting anticholinergic, short-acting beta2-agonist, long-acting anticholinergic, long-acting beta2-agonist, and inhaled corticosteroids), and nonpharmacological treatment (pulmonary rehabilitation) [79]. Aim of pharmacological treatment is to improve the quality of life and exercise tolerance beside achieving the reduction of symptoms and attacks [78]. Inhaled corticosteroids specifically reduce the number of COPD exacerbations [10]. In COPD exacerbation first of all, it is important to identify the etiology. Viral and bacterial infections, air pollution, and environmental factors can initiate COPD exacerbation. Thus, antibiotics and oral steroids are choices of treatment [11].

Hemorheology is a branch of biorheology that focuses on blood and its interactions in both macro- and microcirculation under the influence of the applied constraints [12]. Erythrocyte deformability, red blood cell (RBC) aggregation, hematocrit (Hct), and blood viscosity are well-known components of hemorheology [1214]. The flow properties of blood play significant roles in tissue perfusion. These properties are influenced by pathophysiological processes, including a variety of pulmonary diseases, thereby increasing the clinical relevance of blood rheology information [131517]. In COPD patients, RBC were shown to alter morphologically, like cytoskeleton changes, ultrastructural modifications, and reductions of glycophorin A, band 3, and RBC thiols [71819]. Rheological blood properties were demonstrated to progressively deteriorate as pulmonary insufficiency increases in patients with chronic bronchitis [18]. There are limited number of studies exploring hemorheological alterations in COPD [162022]. The results of these studies were obtained either from COPD patients at different stages of the illness and age [182022] or from patients receiving different types of therapy (medication, exercise) [162023]. Additionally, different types of measurement techniques, some being rather old, were used in a variety of the studies mentioned above, which makes it difficult to compare the results [202124]. Thus, we aimed to determine the possible alterations in RBC deformability and aggregation in newly diagnosed COPD patients and their response to medical treatment and to compare these parameters with values of COPD patients with exacerbations for the first time in the literature. The results of the current study are expected to contribute to the formation of alternative treatment options for COPD.

Statistical Analyses

Continuous variables were expressed as mean ± standard deviation (SD), median (minimum–maximum values), and categorical variables as number and percent. Shapiro-Wilk tests were used for testing normality. If parametric test conditions were satisfied, Analysis of Variance (ANOVA) was used for comparisons among groups. The post hoc Tukey test was used when the ANOVA determined a significant difference. If parametric test conditions were not satisfied, the Kruskal-Wallis Variance Analysis was used for comparisons among groups. The post hoc Mann–Whitney  Test with Bonferroni Correction was used when the Kruskal-Wallis Variance Analysis determined a significant difference. For pairwise comparisons, if parametric test conditions were satisfied, Paired Samples -test was used and if parametric test conditions were not satisfied, Wilcoxon signed rank test was used. All statistical analyses were done by SPSS 21.0. Power of the study was found to be over 95% with 95% confidence ( = 0.05).


In overview, the results of the current study indicate that exacerbations of COPD are characterized by significant hemorheological abnormalities known to adversely affect blood flow. The decrement observed in RBC deformability and the increment shown in erythrocyte aggregation during exacerbations might complement other pathophysiologic mechanisms, leading to worsening of oxygenation and thus clinical symptoms. The mechanisms of the hemorheological alterations could not be clarified. Oxidative stress and inflammation may be involved. Therapeutic approaches including antioxidants for normalizing hemorheological parameters during exacerbations of COPD may also be recommended. However, whether therapies to decrease RBC aggregation and enhance deformability directly and specifically can be developed and whether such therapies will relieve the patient’s symptoms remain an area of active investigation. Further research with a larger number of patients to explain the mechanisms of hemorheological alterations may be necessary.


D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been clinically tested to significantly improve microcirculation.

D’OXYVA’s versatile, over-the-skin, non-toxic CO₂ and soothing vapor delivery system has the potential to dramatically improve microcirculation and the comprehensive function of developing lungs.

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D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.

Pollutants are dangerous compounds for living beings.

Like water, CO2 is vital for life on Earth; thus, CO2 is not a pollutant or contaminant.

The specific heat of CO2 is 850 J/Kg K, which means carbon dioxide is able to absorb, store and emit heat. However, we cannot take this property into account when considering if CO2 is a pollutant because Water has a specific heat of 1,996 J/kg K, which means it is more efficient than CO2 at absorbing, emitting and storing heat. Water, like CO2, is vital for living beings.

CO2 densities have increased to more than 4000 ppmv in some geological eras, for example, during the Ordovician Period (Scotesse; 2002. Avildsen et al1998). When CO2 in the terrestrial atmosphere has reached densities this high in the past, life flourished abundantly. Consequently, we cannot consider such a high concentration of atmospheric CO2 as “pollution”.

CO2 is the basic nutrient for plants and other photosynthetic organisms. Plants form the base of every food chain. Thus, the greater the density of CO2 in a given environment, the greater will be the production of food for plants and of the animals that feed on them.

In recent times it has become fashionable to relate CO2 to global warming, but water in its liquid or gaseous phase absorbs, stores and emits heat 4 times (400%) more efficiently than CO2. If, therefore, by this property water is not considered a pollutant, CO2 then cannot be considered a pollutant either.

Carbon Dioxide cannot intoxicate because it is a non-poisonous non-toxic substance. The data for CO2 related to human health are next:

  • The density of CO2 in the atmosphere is 0.000747 Kg per cubic meter of air.

Normal CO2 Levels. The effects of an increased level of CO2 on an adult person in good health can be summarized as:

  • Normal outside levels: 350 – 600 ppmv.
  • Acceptable levels: up to 600 ppmv.
  • Stiffness and odors: 600 – 1000 ppmv.

Data provided by the Occupational Safety and Health Administration (OSHA):

  • Standards: 1000 ppmv.
  • Stupor: 1000 – 2500 ppm.
  • Maximum allowed concentration in an 8 hour working period: 5,000 ppmv.

Extreme and Dangerous CO2 Levels:

  • Nausea and increase of the cardiac and respiratory frequencies (from oxygen deficiency): 30,000 ppmv.
  • The above plus headaches and sight impairment: 50,000 ppmv.
  • Unconsciousness and death: 100,000 ppmv (OSHA).

As you can see, Carbon Dioxide does not intoxicate — it suffocates. All of the effects listed above correspond to asphyxia, not to poisoning; however, water and sand also asphyxiate and they are not considered pollutants either. Consequently, CO2 cannot be considered a pollutant merely because it asphyxiates.

Many have tried to tag CO2 as a pollutant simply because it is a product of fossil fuel combustion. However, CO2 is also a product of respiration, fermentation and putrefaction. In any case, the CO2 released by combustion of fossil fuels had previously been taken from the atmosphere by photosynthetic organisms and converted into organic compounds to be used in their metabolic functions as structures for reproduction, etc. When those photosynthetic organisms later died, their remains were subjected to strong geological processes that convert organic matter into oil, coal and methane. (Reccommended reading: The Holocene CO2 Rise: Anthropogenic or Natural?)

Those products are the fossil fuels that we use today to power our industries and vehicles; therefore, we are only returning CO2 to the place it once occupied during the Carboniferous Period. CO2 cannot then be considered a pollutant just because it is released back into the atmosphere by combustion of organic fuels and from many other natural processes unrelated with life.


D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been clinically tested to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

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Did you know that it is impossible to have a good health without a good blood?

Did you know that it is impossible to have a good health without a good blood?

It is impossible to have good health without a good blood and it is a good distribution of all organs, systems and cells of the body. The blood carries silicon to the nails, hair, skin and other places “far away” where it is required, and transport to the bone calcium, vitamins, minerals and oxygen to various body parts as well as many important functions within it.

The heart is the force responsible for pumping blood so that it can spread its reach and nutrients. It collects waste materials from different parts of the body too. The blood travels through the body at a speed of 9 mm per second, and during the journey it cleans, nourishes, sterilizes, distributes chemical compounds from food, toxins and helps to purify cells.

Arteries and veins

The veins and arteries are the roads where the blood cells travel inside. The veins carry blood loaded with debris and clean blood in arteries. If any of these avenues is blocked for any reason, you can up of high blood pressure, a result that warns that heart is “pushing” with more force and pressure so that blood can flow through the capillaries and as fast as it should.

If blood cannot flow at a certain speed, then begin to generate a series of severe adverse consequences for the body indicating that there is venous congestion, such as leg pain, swelling, cramps, anemia, or in severe cases, increases the propensity for an attack of paralysis. If the blood does not run optimally, but we eat very well, we can begin to have health problems, this is also noticeable in the appearance of hair and skin, reflecting weakness and opacity due to poor oxygenation and distribution of nutrients to the body.

Knowing the importance of a good circulation, it is necessary to keep not only a diet of good quality but very healthy habits so that your blood and all its components can be shared with vigor and stimulate action in cleansing the blood.

Natural remedies for improve your circulation

Here are some tips for you to improve your circulation:

Look after your heart

There are many ways to keep your heart healthy and strong throughout life, no matter how old you are, you can make your heart pump strongly and full of life. For this, it is advisable to walk and do exercises such as swimming or climbing. The heights are great for the heart, a greater height, greater uptake of oxygen, but you should be aware of your fitness to climb a mountain, it might not react favorably if you’re not used to extreme heights, and you could feel dizzy, with headaches or even vomiting. This only means that your body is not accustomed to it.


To strengthen the heart’s nothing better than chlorophyll liquid foods containing vitamin E, like avocado and olive oil, and pollen and yeast.

Veins clean

Besides a good routine of exercise, it is necessary to avoid in your diet, saturated fats, fried things, animals sausages, meats, milk cows, and so on. This type of fat congests veins, reducing the space through which circulates the blood and causing the heart to put more pressure on the pump. For fragile veins, it is best to eat buckwheat and consumption of foods containing vitamin Csuch as orange, lemon, and so on. Consuming vitamin E is recommended for the muscles, and veins also contain muscle. Oats, raw garlic, celery, avocado and vegetable broths are excellent.


There are many types of breathing that promote good circulation. The rapid inhalations and slow exhalations are recommended. There are practices such as yoga and meditation activities that promote different types of breathing very effective movement.


Believe it or not, having a good mood and being happy with what you do in your life, not only promotes good movement but a movement for quality, full of strength. It is as if some form of heart be given the message “I like to live” and this is justified with such energy. Therefore, it encourages thinking of yearning and attempts to follow it, no matter how young or old you feel, when your mind is full of energy and enthusiasm, your life will be too.

Baths and massages

And finally, bathrooms and massages are very suitable for putting the blood in a very good way. Hot water brings blood to the surface and the cold cut. This remedy is ideal for those people that for any reason are unable to perform physical activity.


D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been clinically tested to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.