Posted on Leave a comment

Depression and cerebral blood flow

Depression and cerebral blood flow

Maybe a benefit will arise from the current debate about the usefulness of antidepressants in depression, if it draws attention to the published studies concerning reduced regional cerebral blood flow in depression which have failed to influence clinical opinion. Perhaps the relevance of such information can be appreciated by reference to the study by Lucey et al. (1) They showed that in patients with panic disorder with agoraphobia, obsessive compulsive disorder and post traumatic stress disorder, there were regional reductions in cerebral blood flow, but in each disorder in different regions of the brain.

It is proposed that depression is the dysfunctional state arising from inadequate rates of blood flow to deliver the necessary oxygen and nutrient substrates to sustain normal tissue function in specific regions of the brain. This means that the condition would be reversible when there were adequate rates of blood flow.

In 1990, Sackheim et al (2) critically examined what had been written about regional cerebral blood flow in mood disorders. An important contribution was made by Bench et al (3) who reported their findings in a study in which previously scanned patients were rescanned on remission. They concluded, “Thus, recovery from depression is associated with increases in regional cerebral blood flow in the same area in which focal decreases in regional cerebral blood flow are described in the depressed state, in comparison with normal subjects.” Similar findings were reported in another paper (4) which reported that the reduced rate of blood flow in the left frontal region which had been observed during depression, returned to normal during remission. The lack of attention given to such findings probably reflects the current antipathy to reports which imply a role for the flow properties of blood (blood rheology).

It is possible to interpret such changes in blood flow in terms of the effects of poorly deformable red cells, which reflect change in their environment by a reduction in fluidity of the the cell membrane. Normalisation of the cell environment restores normal levels of deformability. So it is not surprising that depression is a frequent problem in chronic disorders which are known to have altered blood rheology manifested as increased blood viscosity and poorly deformable red cells, such as in diabetes for example.

Kamada et al (5) in 1986 reported that sardine oil so increased the fluidity of the membranes of diabetic red cells that they were unable to distinguish such cells from those of non-diabetics. Ten years later Maes et al (6) noted that, ” Major depressed subjects had significantly lower C18-3 omega-3 in cholesteryl esters than normal controls. Major depressed subjects showed significantly lower total omega-3 polyunsaturated fatty acids… than minor depressed subjects and healthy controls.” A later study of the omega-3 fatty acid content in the diet and in red cell membranes of depressed patients (7) noted that, “Lower red blood cell membrane n-3 polyunsaturated fatty acids are associated with the severity of depression,” and concluded, “The findings raise the possibility that depressive symptoms may be relieved by n-3 polyunsaturated fatty acid supplementation.”

Ten years later there is no indication that the significance of such findings have been recognised and therapy for depression has been based upon antidepressants rather that omega-3 rich fish oil which might correct the primary problem. Possibly, if the current debate leads to a more public recognition of the problems of cerebral blood flow in depression, then maybe those who suffer from depression will explore the potential benefits of taking 2 x 1000mg capsules of fish oil, three times daily. Many studies have used 10 capsules daily, and one study reported that the maximal tolerable dose was twenty grams daily. Because of the need for the enzyme delta-6-desaturase to be functional in order to utilise the plant derived alphalinolenic acid, it is safer to use fish oil as a source of omega-3 fatty acids. An alternative would be to increase the dietary intake of omega-3 fatty acids by including sardines or oily fish in meals on a daily basis.

In addition, because regular light exercise has been shown to reduce blood viscosity, an activity such as walking or dancing should be part of the daily programme. A good example was an Australian study involving “pram pushing” which was shown to be beneficial for women with post-partum depression.

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been clinically tested to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

Posted on Leave a comment

D’OXYVA on cellulite and fat reduction

Cellulite is a symptom of abnormal fat cell growth and an inflammatory response under the skin’s dermis layer. The skin’s dermis layer is known as the living skin, and it is composed of nerves, elastin, fats, blood vessels, and collagen fibers, which provide elasticity. With age, our skin produces less collagen, causing the skin to look wrinkled and saggy. Also, fat cell growth or expansion within the well-delimited hypodermis skin layers compromise effective O2 supply from the vasculature (microcirculation) and push the outer skin layers up while the fibrous septa pull it down. This physical action, which is due to fat cell overgrowth, causes the skin to have an orange-peel and cottage-cheese appearance.

Our body’s physiological response to hypoxia is well known. Hypoxia provokes an inflammatory response associated with the overproduction of adipokines, interleukins, macrophages recruitment, and increased glucose sensitivity (GLUT-1 expression). In other words, when cellulite appears in our skin, we have two major problems: disruption of the dermis skin layer architecture due to abnormal fat cell growth and an inflammation response caused by hypoxia. Substantial evidence suggests that hypoxia (low SpO2 ) is a protagonist in adipose physiology and in adverse bodily responses associated with obesity.

D’OXYVA gentle, super-saturated CO2 vapor causes instant artery microcirculation and venule dilation, thereby improving blood flow. By improving the skin layer’s blood flow, it allows our body to stimulate circulation, detoxify, balance, and increase O2 delivery. D’OXYVA® allows our body to self-heal, particularly by adjusting the fat cell microenvironment. As a result, fat cells decrease their growth rates through a reduction in glucose sensitivity and the promotion of catabolism. After D’OXYVA® administration, the inflammatory response decreases due to the elimination of the hypoxia state.

After adhering to a D’OXYVA® treatment plan, cellulite patients will find significant improvement in their skin’s appearance and feeling.

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been clinically tested to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

Posted on Leave a comment

Did you know that it is impossible to have a good health without a good blood?

Did you know that it is impossible to have a good health without a good blood?

It is impossible to have good health without a good blood and it is a good distribution of all organs, systems and cells of the body. The blood carries silicon to the nails, hair, skin and other places “far away” where it is required, and transport to the bone calcium, vitamins, minerals and oxygen to various body parts as well as many important functions within it.

The heart is the force responsible for pumping blood so that it can spread its reach and nutrients. It collects waste materials from different parts of the body too. The blood travels through the body at a speed of 9 mm per second, and during the journey it cleans, nourishes, sterilizes, distributes chemical compounds from food, toxins and helps to purify cells.

Arteries and veins

The veins and arteries are the roads where the blood cells travel inside. The veins carry blood loaded with debris and clean blood in arteries. If any of these avenues is blocked for any reason, you can up of high blood pressure, a result that warns that heart is “pushing” with more force and pressure so that blood can flow through the capillaries and as fast as it should.

If blood cannot flow at a certain speed, then begin to generate a series of severe adverse consequences for the body indicating that there is venous congestion, such as leg pain, swelling, cramps, anemia, or in severe cases, increases the propensity for an attack of paralysis. If the blood does not run optimally, but we eat very well, we can begin to have health problems, this is also noticeable in the appearance of hair and skin, reflecting weakness and opacity due to poor oxygenation and distribution of nutrients to the body.

Knowing the importance of a good circulation, it is necessary to keep not only a diet of good quality but very healthy habits so that your blood and all its components can be shared with vigor and stimulate action in cleansing the blood.

Natural remedies for improve your circulation

Here are some tips for you to improve your circulation:

Look after your heart

There are many ways to keep your heart healthy and strong throughout life, no matter how old you are, you can make your heart pump strongly and full of life. For this, it is advisable to walk and do exercises such as swimming or climbing. The heights are great for the heart, a greater height, greater uptake of oxygen, but you should be aware of your fitness to climb a mountain, it might not react favorably if you’re not used to extreme heights, and you could feel dizzy, with headaches or even vomiting. This only means that your body is not accustomed to it.

Diet

To strengthen the heart’s nothing better than chlorophyll liquid foods containing vitamin E, like avocado and olive oil, and pollen and yeast.

Veins clean

Besides a good routine of exercise, it is necessary to avoid in your diet, saturated fats, fried things, animals sausages, meats, milk cows, and so on. This type of fat congests veins, reducing the space through which circulates the blood and causing the heart to put more pressure on the pump. For fragile veins, it is best to eat buckwheat and consumption of foods containingvitamin Csuch as orange, lemon, and so on. Consuming vitamin E is recommended for the muscles, and veins also contain muscle. Oats, raw garlic, celery, avocado and vegetable broths are excellent.

Breathing

There are many types of breathing that promote good circulation. The rapid inhalations and slow exhalations are recommended. There are practices such as yoga and meditation activities that promote different types of breathing very effective movement.

Enthusiasm

Believe it or not, having a good mood and being happy with what you do in your life, not only promotes good movement but a movement for quality, full of strength. It is as if some form of heart be given the message “I like to live” and this is justified with such energy. Therefore, it encourages thinking of yearning and attempts to follow it, no matter how young or old you feel, when your mind is full of energy and enthusiasm, your life will be too.

Baths and massages

And finally, bathrooms and massages are very suitable for putting the blood in a very good way. Hot water brings blood to the surface and the cold cut. This remedy is ideal for those people that for any reason are unable to perform physical activity.

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been clinically tested to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

Posted on Leave a comment

Did you know that poor microcirculation can lead to chronic venous insufficiency?

Chronic venous insufficiency is a widespread disease of great socio-economic relevance. It is characterized by accompanying venous hypertension due to valvular dysfunction or valvular insufficiency. The high pressure in the calf veins is transmitted to small venules and skin capillaries. Characteristic symptoms are skin edema, trophic skin changes, lipodermatosclerosis, and finally venous ulcers.

These in essence microcirculation phenomena have attracted the interest of the researchers in the field of basic and clinical microcirculation. Functional and morphological changes in the microvasculature,microymphatics and the venous draining systems have been described, whose conjugated action might explain the development of chornic venous insufficiency, i.e. venous ulcers. Chronic venous insuffieciency has been particularly resistant to treatments. To counteract the high venous pressure, compression therapy has been used for many years. New develpoment includes vaso-active drugs with a preferential effect on the tone of veneous vessels and microvascular permeability. It appears that some of these drugs can restore the microvasculas and diminish leukocyte/endothelium interaction as well as micromolecular leakage.

Read whole book, here

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been clinically tested to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.