Peripheral edema is the result/manifestation of many diseases, inflammation processes, and loss of body compensatory mechanism of chronic conditions, but the first pathophysiology disturbance is at the capillary level (microcirculation). D’OXYVA® transdermal CO2 application has demonstrated to be beneficial to improve blood flow by decreasing microcirculation blood resistance and improving venous insufficiency. CO2 is one of the few local humoral mediators with the potential to modulate blood flow in capillary beds. CO2 enhances the following capillary bed functions:
– Arteriole elastic retractions and vasomotion that allows constant blood flow through the capillary bed.
– Reconstruct the role of adjacent closed capillaries.
– Promote vasodilation of the arterio-venous anastomosis without increased venous return.
Also, CO2 is a natural anti-inflammatory agent that helps one’s circulatory system to perform better. CO2 especially helps one’s circulatory system by increasing venous blood return to the heart and systolic output by passive peripheral vasodilation, without increasing mean arterial blood pressure.
It is important that any patient who has edema needs to be followed/supervised by a physician because there is the need to assess critical organ functions and etiology of the disease, like BP, venous obstruction, low plasma protein concentration, or lymphatic obstruction among others.
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