The Paradigm Shift In

The improvement of microcirculation is widely reported in mainstream medical literature to provide exceptional benefits for health and clinical outcomes.

D’OXYVA’s strong results are pushing the boundaries of today’s science to new frontiers.

You may learn more about the various benefits from independent published papers online and we welcome you to read more in detail. We created the following brief list for your convenience as just a few examples to get you started.
The assessment of microangiopathic disease is a new science with early clinical applications. As new technologies are developed physicians will increasingly be able to extract information about the vascular status of potent ially ischemic areas while providing a greater understanding of the pathophysiology of the diabetic lower extremity. Read More >>
This study underscores the importance of the renal microcirculation in  enovascular disease. Intra-renal administration of VEGF preserved renal MV architecture and function of the stenotic kidney, which in turn preserved renal haemodynamics and function and decreased renal fibrosis. Read More >>
Many aspects of the pathophysiology of venous disease
remain to be clarified, particularly the initial phases of microcirculatory injury which ultimately result in leg ulceration. Leucocyte activation occurs after short periods of venous hypertension, even in control subjects, and may be one of the factors that cause endothelial damage to cutaneous capillaries if it continues over many months or years. Read More >>
The present review of the current literature shows persistent microcirculatory alterations in critically ill adult and pediatric patients. In addition, the literature shows that various therapeutic  approaches are effective in recruiting the microcirculation. Nevertheless, it is unclear whether such a therapeutic approach aimed at recruiting the microcirculation contributes to an improved outcome.
Microcirculatory dysfunction is emerging as a relevant pathogenetic mechanism for ischemic heart disease. It manifests as a paradoxical increase in resistance to flow in response to reduced perfusion pressure, and contributes to the  precipitation of ischemic attacks in both stable angina and acute coronary syndromes. Read More >>
The research reviewed in this article suggests that impaired tissue perfusion due to abnormality of the microvascular
system is common among the conventional cardiovascular risk factors, including hypertension, diabetes, obesity, and
dyslipidemia. Microvascular changes are hallmarks of the long-term complications of hypertension and diabetes; however, it is now clear that microvascular changes occur very early in these conditions and may be important in their pathogenesis and progression. Read More>>
Abnormalities of microvessel structure and microvascular network density often accompany, and may be an important cause of, primary hypertension.  Microcirculatory abnormalities are also likely to be central to many forms of hypertensive end-organ damage, including those involving the kidneys, heart, and brain. Optimal antihypertensive therapy should therefore be targeted at both large and small vessels. 
Recent experimental, clinical and epidemiological investigations have delivered completely new insights into obesity, both on its origins and its relations to diabetes and cardiovascular diseases. To a large extent these new data challenge classical concepts about a “simple” relation of overweight with these diseases, allowing to predict that in a hopefully near future obesity will be considered in practic every differently from today.
The role of microcirculation in skeletal muscle is to provide the supply of oxygen and various nutrients and to remove waste products of muscle metabolism. As skeletal muscles are composed of different fibre types, this review tries to elucidate the question of capillary supply and flow with respect to these. Read More >>
Obesity is an important risk factor for insulin resistance and hypertension and plays a central role in the metabolic syndrome. Insight into the pathophysiology of this syndrome may lead to new treatments. This paper has reviewed the evidence for an important role for the microcirculation as a possible link between obesity, insulin resistance and hypertension. Read More >>

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