Read expert reviews below or click here for user reviews. Our company has been receiving and recording many benefits related to a wide variety of medical conditions. We only share some of them publicly for regulatory reasons.

Our products are the subject of various ongoing human clinical trials seeking clearance by the U.S. Food and Drug Administration (FDA) and other health authorities around the world for a variety of chronic and acute health conditions.

Please chat or call or email us and share your experience and results. We are excited to inform people about the great benefits of using D’OXYVA®.

Dr. Geoffrey Watson
Watson Wellness Center, Oakland, CA
Bachelor of Science in Health Care Administration from the University of California
Specialist in the art of internal medicine
President of the Sinkler Miller Medical Association, 1996–1997

“We at Watson Wellness Center in Oakland, CA, are thrilled to announce the launch of a new clinical trial aimed at treating the main underlying medical conditions related to the most severe COVID-19 cases, in partnership with Circularity Healthcare, the makers of D’OXYVA.

This groundbreaking clinical trial will feature the administration of Circularity’s latest patented and patent-pending, noninvasive and painless, ultra-portable, transdermal (over the skin) drug-delivery device D’OXYVA® (deoxyhemoglobin vasodilator). D’OXYVA has consistently demonstrated success over eight years of involvement in dozens of human studies and has received user feedback from thousands of people in dozens of countries when other drugs and treatment options have failed. D’OXYVA directly addresses the issue of low-oxygen blood flow, which is especially important for at-risk COVID-19 patients.”

Dr. Michael McGlamry
Forsyth Foot & Ankle Associates, Cumming, GA
Bachelor of Science in Engineering from the University of Florida
Doctorate of Podiatric Medicine from Pennsylvania College of Podiatric Medicine/Temple University

“Diabetic patients, particularly those with more longstanding and poorly controlled disease, suffer from diminished oxygen-rich blood in their microcirculation. D’OXYVA has shown significant promise for severe cases of diabetic foot ulcers. Its therapeutic effects have circulatory and neurological benefits as well.

Over two dozen studies have demonstrated convincing results at clinics and at home, with no adverse events. D’OXYVA has recorded significant results, delivering major outcomes for well over 90% of users. Studies with D’OXYVA have shown unmatched results in noninvasive wound care – particularly when all other approaches have failed. D’OXYVA provides an adjunct to accelerate comprehensive wound care programs and infection protection as a painless, affordable non-prescription solution available in a clinical setting, or in the comfort and privacy of your own home.”

Dr. Felix Sigal D'OXYVA | Cardiovascular, Diabetes, Wound Care, Pain Relief
Dr. Felix Sigal
Foot and Ankle Clinic
Diabetic Limb Salvage Specialist

“Disseminated intravascular coagulation (DIC) is one of the severe complications related to COVID-19. This is a serious disorder in which the proteins that control blood clotting become overactive, which can result in symmetrical peripheral gangrene. The Circularity OTC device is a novel transdermal delivery system that can deliver carbon dioxide directly to body tissues low in oxygen. Further studies are needed, but this device has the potential to prevent symmetrical peripheral gangrene, a limb-threatening complication of COVID-19.

D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.
Keshen Mathura
CMO - MicroVision Medical, Amsterdam, Netherlands

“The results were pretty astonishing, there was a 6% increase in capillary length (meaning more blood-filled capillaries) and a 14% increase in capillary diameter measuring results with MicroScan after just a few minutes of a single 5-minute (16g CO2) application. The results are more pronounced when considering small vessels (< 20 microns), which include the capillaries. Our early tests suggest D’OXYVA significantly improves blood circulation in the tiniest vessels and more profoundly in people with imbalances in their body than young healthy people.

We are proposing a clinical trial for rheumatoid arthritis patients where we expect significant pain reduction coupled with equally significant circulation improvements in just a month.” 

D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.
Chairperson, Research Cooperation Affairs at Institute of Tropical Disease, Airlangga University Surabaya
Chairperson, Ministry of Education and Culture, Rep. Indonesia, Board of Higher Education, Research Council
”It works well, proven by the improvement of the perfusion index (PI-Masimo) of the diabetic wounds of Grade Wagner-I and Wagner-2 after a series of 5 applications. We continued the work by measuring TcPO2 (SENTEC) in another group of 15 patients with the same protocol, whereby we can prove that the skin delivery CO2  application of D’OXYVA results in wound solution improvement.”
D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.
Professor of Biomedical Sciences
Education B.S. Rockhurst University, Kansas City, Missouri
Ph.D. University of Missouri
Member at the American Physological Soceity, American Microcirculatory Society, American Heart Association
”Toriyama et al. studied the effect of CO2 bathing in 83 limbs with critical ischemia and achieved limb salvage in 83% without surgery. They concluded that peripheral vasodilation from CO2 bathing resulted from an increased parasympathetic and decreased sympathetic activity. Application of skin delivery CO2 produces a remote vasodilation that may be mediated through release of a circulating humoral agent.Recently, studies have documented that episodes of brief, non-damaging ischemia occurring in a tissue can induce systemic protection against ischemia-reperfusion injury in a remote organ. This phenomenon, termed remote ischemic conditioning, has been demonstrated to confer protection against ischemic events in the myocardium, brain, and kidney. Although shown to be effective in various clinical and pre-clinical models, the mechanism(s) of remote protection have not been clearly identified.Both neural and humoral mechanisms have been proposed to contribute to the protection against ischemic damage afforded by remote ischemic conditioning. Basalay et al. have shown that when remote ischemic conditioning is applied before induction of myocardial ischemia, sensory nerves and recruitment of a parasympathetic neural pathway are involved in reduction of infarct size. Recently, Michelsen and colleagues have demonstrated that dialysate of human plasma from subjects who underwent either ischemic preconditioning or exercise preconditioning reduced infarct size in rabbit hearts, indicating that release of a humoral factor, contributes to the cardioprotective effects of ischemic and exercise preconditioning; however, these circulating substance(s) remain to be identified.Future investigations will need to monitor heart rate, heart rate variability, and sympathetic nerve activity in order to more fully assess the role of the autonomic nervous system in mediating the sustained increases in SPP and systolic blood pressure reported in this initial study and focus on assessment of plasma samples during and following skin delivery CO2 application. The D’OXYVA device is safe and can be administered at home. There are a lot of possibilities here and we are really excited about conducting future studies to determine what D’OXYVA may be able to provide to people with microvascular disease.”
D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.
Holistic Practitioner (20 years)
Reflexologist, Master Herbalist, Iridologist
Clinics: Pensacola, FL and Jackson, MS
”I have been using the D’OXYVA for past 4 years. After I started using the D’OXYVA, I felt a major improvement in my breathing because my sinus issues had cleared up. Second, I stopped snoring. After about 4 months, I realized that my muscles felt better and I was gaining my muscle mass back.Then, I realized the varicose veins in my ankles had been reduced to less than 1/3 of it was. I have had a major reduction in pain and inflammation throughout my body. Now 4 years later, I feel physically stronger than I did 20 years ago. I am still increasing my muscle mass just by daily stretching, deep breathing and doing a D’OXYVA application three times weekly. I know that the D’OXYVA applications have caused my body to feel good again.I have clients that have had similar and various results. One client has reported a major improvement in their eyesight. Six different clients have reported a reduction of varicose veins. A lot of clients have reported reduced amounts of inflammation and pain. Some clients have reported an increase in energy and endurance.The fact is that the D’OXYVA increases the effectiveness of the Microcirculatory System. The body will feel better because of Microcirculatory System will improve the blood flow throughout the body. Increasing the blood flow will help the body improve itself.I can highly recommend everyone should be doing D’OXYVA applications on a regular basis. You will be able to feel the difference.”
D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.
German Board Certified Dermatologist, GMC Registered Doctor
Awarded the title of Specialist in Dermatology and Venereology by the Hamburg Medical Council
Awarded the British Leverhulme and the French Rene Touraine
Author and co-author of 100 scientific articles, book chapters and abstracts

”At European Dermatology London we use the D’OXYVA device after non-surgical aesthetic procedures to help reduce the down-time for patients; and as part of our Medical-grade Pedicures for diabetic patients, who often suffer with impairments in their feet’s microcirculation.”

D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.
Integrative Health Centers Practice Developer and Physician
Health and Wellness of Carmel Practice Physician American Health Network Independent Primary Care Physician
Author and co-author of dozens of healthcare articles, book chapters and abstracts
”Circularity has a novel, affordable solution for patients. The D’OXYVA delivery system can be purchased by the patient and they have it in their homes for the rest of their lives. They can then treat pets and family members with a 7 minute solution per day for about the same daily cost as a Starbucks coffee. The cumulative benefits of using D’OXYVA daily are immeasurable in so many health conditions.My experience with patients in my Functional medicine practice was that 7/10 patients felt an immediate calming effect after one solution. We documented most patients had a five point drop in blood pressure and pulse decrease within five minutes of one solution. I am intrigued with the new data physicians will be presented with the clinics’ diagnostic platform. However, most doctors will have few solution options to suggest other than diet and exercise and nutraceuticals.Physicians who adopt D’OXYVA will be able to offer their patients with a novel, effective, affordable way to address these imbalances. And they can be delivered in the comfort of their own home. This is the perfect storm!”
D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.
Head of Central Operation Room and Sterilization Unit
Vice Chairman Trauma Department at University of Szeged Albert Szent-Gyorgyi Clinical Center
Professor of Trauma Surgery Founder and Board Member ATLS European Commitee
Author and co-author of hundreds of scientific articles, book chapters and abstracts

”In every 30 seconds a diabetic lower limb is lost somewhere in the world. For this reason diabetes and wounds is a dangerous combination; therefore, the management can be difficult. The standard solution of a diabetic wound includes accurate surgical debridement and controlling the diabetic metabolism, as well as eliminating the infection by means of antibiotic solution. In our presented case an insulin-dependent diabetic patient was treated for trimalleolar ankle fracture combined with very serious soft tissue destruction.

After admission to our department the possible solution options were amputation or a long-term combined surgical solution. The patient underwent a very drastic surgical debridement, the necrotised skin was removed. Infection was diagnosed with the identified pathogens being Enterobacter cloacae and ludwigii, Acinetobacter sp., Proteus mirabilis and Escherichia coli. After microbiological consultation an adequate antibiotic solution was introduced. Every two days we repeated the surgical debridement and we applied jet lavage. After ten days there were no further necrotised tissue so we continued with a VAC solution for two weeks. With the assistance of a plastic surgeon we applied Integra® and after a few days a split-thickness skin graft. Patient’s compliance dropped off and needed psychological support. During episodes of confusion he removed the dressings and surprisingly after two weeks fly larvae (Diptera: Sarcophagidae) were found in the skin grafted area.

Then wound improve was accelerated by Bioptron®  light solution and D’OXYVA® (deoxyhemoglobin vasodilator) solution was applied twice a day for 25 days. His wound nearly completely healed and closed after 25 days and he could walk with crutches. He was discharged home after three months of solution.

CONCLUSION: Even a serious soft tissue damage can improve after applying adequate solution, but in diabetic patients the decision is difficult. It is important to note that in order to avoid amputation, multidisciplinary approach is mandatory. The patient’s general condition, life expectancy, and compliance basically influence our decisions and during the solution period we have to reassess the results and taking these factors into account, thus we can choose the best solution option.”

reinhard bergel
University of Cologne M.S. Diplom Sportlehrer (exercise science-physical education & physical rehabilitation)
University of California at Los Angeles M.S. Kinesiology
University of California at Berkeley PhD (Education & Exercise Science)
Co-author The Spa Encyclopedia and dozens of scientific articles, book chapters and abstracts

My wife and I definitely noticed a significant increase in vascular aerobic abilities and general vitality. In addition, we exercise aerobically every morning for 50 minutes in our hills and swim 30 minutes. We use this age-old method now available in a powerful advanced small device in the evening before going to bed and it’s a fantastic boost.

D'OXYVA | Cardiovascular, Diabetes Care, Pain Reliever in CA.
Wound Care and Cardiothoracic Surgical Unit, Hospital Raja Perempuan Zainab II, Malaysia
Department of Community Medicine, School of Medical Sciences, Universiti Sains Malaysia, Malaysia

”After four weeks, the patient clinically improved from heart failure symptoms. Objectively, his LVEF was increased from 37.17% to 46.99% and the PaO2 increased from 84.5mmHg to 104.7mmHg.

With no obvious cofounder observed, the deoxyhaemoglobin vasodilator works to improve the LVEF and attenuated the heart failure symptoms. It increased perfusion thus bolstering microcirculation of the heart muscle after the CO2 saturation was increased and induced the vasodilation through Bohr effect.

This great preliminary finding suggested for further studies to be conducted with larger sample size and more objective cardiac function assessment such as through Cardiovascular Magnetic Resonance Imaging (MRI)”


Blog Posts

Reduce unwanted doctor visits, recommended and ranked top by experts!