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What You Need to Know About Non-Healing Wounds

Chronic wounds are wounds that do not heal in a normal amount of time. This delay in healing can be due to a number of factors. Read on to learn about the case of a 63-year-old female patient with a large chronic wound on her lower, left extremity that was resistant to healing.Lena was a 63-year-old, White female who had developed a large, non-healing wound on her lower, right leg. She could not remember what had caused the lesion other than having dropped a heavy mirror on her right shin several weeks earlier. Lena had a past medical history of high blood pressure, diabetes, heart failure, liver failure, and blood clots in her legs. She had been a cigarette smoker for the last 50 years.Lena’s physical examination showed a large, deep, non-healing wound on her right shin. Surgical treatment and debridement, along with antibiotic treatment, had failed to result in significant treatment. After 8 weeks of adjunctive application with deoxyhemoglobin vasodilator D’OXYVA[1], the chronic wound improved without any further complications.
Main Reasons Chronic Wounds Do Not Heal
Chronic wounds normally do not heal for a number of reasons, including[2]:
  • Increased age of the patient leading to slower healing time
  • Decreased functioning of the immune system due to illnesses or chronic disease processes
  • Decreased circulation due to diabetes affecting the peripheral vascular system
  • Decreased circulation due to peripheral vascular disease
  • Peripheral neuropathy leading to loss of sensation and the inability to feel wound and ulcer formation
  • Insufficiency of the venous system leading to pooling of blood in the extremities and resultant poor perfusion
  • Poor nutrition leading to decreased ability to heal wounds normally
  • Impaired mobility leading to impaired limb perfusion
  • Increased general stress levels leading to decreased wound healing
  • Decreased general health causing general debilitation and loss of normal healing ability
Variations of Chronic Wounds

There are several different variations of chronic wounds, including pressure ulcers, arterial and venous ulcers, and diabetic ulcers.

Pressure ulcers[3], such as “bed sores,” occur when an area of the skin is under constant pressure, often when a patient is confined to a bed or wheelchair.

This causes the skin to break down in areas such as the coccyx, heel, ankles, and dorsum of the foot.

Arterial ulcers[4] form when there is a blockage in an artery causing reduction in blood flow to the lower extremities and subsequent reduction in the supply of oxygen to the affected area.

Venous ulcers[5] occur when the valves within veins become damaged leading to pooling of blood in the veins and reduced blow flow and oxygenation to the extremities.

Diabetic ulcers occur when high blood sugar levels cause damage to the nerves, especially in the lower extremities.

This leads to numbness, causing the patient to ignore cuts or ulcers until they enlarge, often becoming infected.

Diabetes also depresses the immune system, leading to slowed healing.

Treatments for Chronic Non-Healing Wounds

There are a number of treatments for non-healing wounds [7]. These include:

  • Antibiotics to treat bacterial infections
  • Antifungals to treat fungal infections
  • Hyperbaric oxygen treatments to improve chronic wound healing
  • Surgical debridement to remove necrotic tissue
  • Specialty wrapping of chronic wounds
  • Skin grafting to close chronic wounds
  • D’OXYVA[8]skin delivery deoxyhemoglobin vasodilator as a wound solution to improve blood flow and oxygenation to chronic wound areas

HOW D’OXYVA CAN HELP?

D’OXYVA® (deoxyhemoglobin vasodilator) provides advanced, painless, complete and fast wound care solution. It has demonstrated speeding up diabetic wound improvement to an average of 5 weeks**.

In addition, D’OXYVA  improved quality of life such as sleep, appetite and mood in just a week in 100% of subjects. No adverse events of any kind were reported during, and years after the studies.

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16 Signs You’re at Risk for Diabetes

Diabetes is a serious, chronic illness that can result in the loss of limbs or life if left untreated. There are many signs that you are at risk for developing the disease, and it’s important to know what they are. If you experience any or all of the following and can’t find a suitable explanation, make an appointment with your doctor.

If you get plenty of sleep every night but still go through bouts of fatigue throughout the day, it may be a sign you’re pre-diabetic.
Having to pee often or a lot (and even wetting the bed at night) is a classic sign you’re at risk for diabetes. If you begin to suspect you’re outside the norm, make a note every time you go to the bathroom and take the information to your doctor, who will let you know whether you need further testing.
Excessive thirst (when you’re not also doing a lot of sweating) is also somewhat suspicious. Track water intake for a few days while you wait to see your doctor. It could be an early symptom of type 2 diabetes, which has subtle signs, like thirst and frequent trips to the bathroom. Don’t ignore them.
It can be hard to separate “eating when you’re hungry” from “emotional eating.” But if you find yourself having actual hunger pangs often and beyond mealtimes, it may mean you’re at risk for diabetes.Bring it up with your doctor and track any other symptoms of risk, so she can determine whether more testing is advised.
A big risk for type 2 diabetes is if you have a terrible diet, one that is high in sugar, carbohydrates, and lots of processed foods. If you know you don’t eat well and especially if you show any other signs that you’re at risk for diabetes, talk to your doctor about it. Yes, you will be advised to make better choices. But you should know whether you’re headed to diabetes territory — or worse, that you’re already there.
Blurry vision is often one of the first signs of diabetes. If you can’t explain away fuzzy letters, or have the sudden inability to read texts and signs that had been readable before, flag this with your doctor.Interestingly, insulin treatments for diabetes also can blur vision. Know that your eyes are a window into your health. See the signs.
There can be several causes for a lack of saliva in your mouth (also known as “dry mouth”), and high levels of glucose is one of them. This puts you at risk for (or is a symptom of) diabetes.There are some pharmaceutical treatments for dry mouth. But before treating it, be sure to talk to your doctor about what you’re experiencing so that you can be tested for diabetes.In any case, dry mouth can lead to cavities and an increase in yeast infections in your mouth, so do not ignore it.
If you find that your clothes are getting tighter and tighter, particularly around the waist, you might be increasing your risk for developing diabetes. Talk to your doctor about it and take their advice, especially if changes in your eating and exercise routine are in order.
Headaches alone aren’t serious, but if you get them often enough it might be a sign that your blood sugar is out of whack — which may be a sign of diabetes. If you suspect this might be the case, or if you find the headaches are becoming regular and aren’t due to sleep issues or dehydration, bring it up with your doctor.
Mood swings have long been an early symptom of a hyperglycemia attack and type 2 diabetes. The mood swings might also be a consequence of suffering from other symptoms of the disease. Either way, don’t ignore them: Moodiness and depression might be your body telling you something really isn’t right.
People with diabetes often take much longer to heal from scrapes and cuts. They are also at risk for frequent infections.If you experience any of these symptoms, it could mean something else is going on. See your doctor to rule out or diagnose diabetes.
A sedentary lifestyle puts you at risk for lots of health ailments, including diabetes. Without regular exercise and movement, you’re at risk for a not well-regulated metabolic system, which, in turn, holds on to fatty deposits. That puts you in the higher risk category for developing type 2 diabetes.Do what you can to prevent it.
There are a number of specific skin problems related to diabetes. One particularly visible one is the darkening and thickening of skin, especially in the skin folds. Called acanthosis nigricans, it appears mostly in people who are very overweight.Sometimes, the skin becomes slightly raised and appears velvety. Other times, it looks like small warts on the side or back of the neck, armpits or in the breast and groin area.
If you’ve experienced sudden (and unintentional) weight loss, you might be at risk for diabetes. The lowered weight, in these cases, is due to high blood sugar, dehydration, muscle breakdown and thyroid problems — all of which are serious and should be understood and treated by a doctor.So, while your jeans might start fitting better, this sudden and dramatic weight loss is nothing to get excited about.
High blood sugar can cause diabetic neuropathy, which damages the nerve pathways that send signals to the hands and feet. Hands and/or feet that feel tingly might be showing early signs of this damage and may certainly be a symptom of diabetes.Don’t ignore the discomfort or blame your shoes. Make an appointment with your doctor and get tested.
High blood sugar changes the balance in our bloodstreams and bodies, and makes us less effective in fighting off infections. Consequently, people with diabetes often experience urinary tract infections and yeast infections.If you haven’t been diagnosed with diabetes but you’re battling both often enough, let your doctor know. These conditions might be a sign that you’re at risk for developing full-blown type 2.

      BUY D’OXYVA

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless over-the-skin microcirculatory solution that has been validated to significantly improve microcirculation.

The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

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Healthy Choices and Technology Equals Better Diabetes Management

By Justin Bennet

According to the American Diabetes Association, 1.5 million people are diagnosed with diabetes every year, 84.1 million Americans are considered prediabetic, and diabetes is in the top 10 causes of death in the US. These are alarming statistics, which can be unsettling if you have diabetes. However, living with a chronic condition in the 21st century means that you have access to technology and information that wasn’t available even as recently as the 1990s.

Smart Tech for Diabetics

Technology has done so much for medicine. There are now robots that can assist with surgery and devices you can wear to monitor everything from your heart rate to how much you sleep at night. Apple’s Series 4 smartwatch, for example, can output an ECG directly on the screen. It will also let you call for help via an emergency SOS function if you get into a bad situation.

Perhaps more importantly, this and other fitness trackers, such as the Fitbit, can help you keep tabs on your exercise routine by counting your steps and calculating your average active time each day. Knowing how much movement you get is paramount to keeping your body fit and healthy. Exercise, according to EndocrineNet, can help you manage your blood glucose levels.

Technology can go one step further by allowing you to take your exercise routines with you no matter where you are. Apps such as MyFitnessPal and 8Fit can encourage you to make healthy exercise choices, and they can also help you monitor what you eat, which is another crucial element related to diabetes management.

Your Actions Matter

While technology can give you the tools to take control of your health, ultimately, it is your actions that direct the path of your well-being.

A few things you can do to stay healthy are:

  • Maintain a relationship with your doctor. Your primary care provider will likely be the one to diagnose you with diabetes. Once the condition is established, they will refer you to an endocrinologist, who may work at an independent office, the hospital, or at a diabetes care center. Make sure to keep your appointments with both, and don’t be afraid to ask questions about caring for yourself. If you have yet to find an endocrinologist, sites like HealthGrades can help you make an informed decision.
  • Exercise and eat right. We’ve already mentioned how technology can help you exercise and eat right, but both of these deserve special emphasis. When you have diabetes, it is not enough to simply eat the right foods; you also have to avoid the wrong ones. Things like white bread, French fries, and sports drinks might seem innocent enough, but they can send your blood sugar skyrocketing while expanding your waistline. You’ll also want to enhance your diet with diabetes-safe supplements to help you manage your weight and keep it within an acceptable range. Nutrition is what gives your body the energy to function, and adding polyphenols and other lesser-known nutrients to your daily intake is an important step in managing your condition.
  • Take your medicine on time. If your doctor has put you on a prescription for your diabetes, it’s important to take it at the same time every day. This is another area where technology can enhance your self-care efforts via medication reminder apps. Pharmacist Christina Tarantola lists several of her favorites and also cautions that around half of all prescriptions are taken incorrectly.

When it comes to diabetes management, technology can get you halfway there. However, what you choose to do with it and the lifestyle decisions you make mean the difference between living with your condition and letting your condition rule your life.

      BUY D’OXYVA

HOW D’OXYVA CAN HELP?

Do you own a wearable fitness tracker? Is it really a fitness technology or just more of a fad? If your wearable records heart rate, blood pressure, blood sugar, blood flow (perfusion index), blood oxygen (SpO2), blood pH, we challenge you to prove that you have the best wearable by testing its efficiency with D’OXYVA.

D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been validated to significantly improve microcirculation.

Results of improved blood flow (perfusion index) is visible in just after 5 minutes of D’OXYVA therapy and on its highest just after 30 minutes!

Are you up for the challenge? Register below to get further details! Amazing prizes await!

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Prevention of Amputations in Diabetics

Prevention of Amputations in Diabetics

A major risk of having diabetes is the possibility of requiring an amputation. Most frequently, amputations due to diabetes first involve the great toe with worsening gangrene, which leads to amputation of the foot, amputation of the leg below the knee, and then amputation of the leg above the knee. The following is a case study of Douglas, who was a diabetic patient who required an amputation of his lower leg beneath the knee in order to survive.

Case of a Sixty-Three-Year-Old Man with an Amputation of the Left Lower Leg from Uncontrolled Diabetes

Douglas was a sixty-three-year-old patient with a past medical history that was significant for Type 2 diabetes mellitus and high blood pressure with an inability to walk more than two blocks without shortness of breath. Because his blood sugars were continually out of control even on insulin, Douglas developed damage to the nerves in his feet (peripheral neuropathy). This led to his inability to feel an ulcer forming on the tip of his left great toe. In addition, since his diabetes led to damage to the microcirculation (smallest blood vessels) in his feet, his ability to rapidly improve  from the ulcer was significantly delayed. Within forty-five days of the first occurrence of the blister, it became infected, which led to gangrene and sepsis and admission into the intensive care unit. The gangrene kept spreading, requiring first the amputation of his left great toe, then the amputation of his left foot, and finally the amputation of his entire left leg below the left knee. This case demonstrates how the extreme and potentially deadly risk of leg amputations in diabetics can be reduced through early diagnosis of the problem and aggressive preventative care, including the use of D’OXYVA[1].

D’OXYVA is a peripheral and noninvasive deoxyhemoglobin vasodilator that dilates the microcirculation (D’OXYVA delivers pharmaceutical grade CO2 and water vapor transdermally (through the skin), dilating the smallest veins, arteries, and capillaries while increasing peripheral blood flow to the lower extremities. D’OXYVA is a pain reliever that is given for fast pain relief treatments, which are known to reduce pain and chronic conditions.

Risk Factors for Amputations in Diabetics

In a study published in the Journal of Developing Countries in 2008, it was found that, of 146 diabetic patients studied who had amputations of the foot, 74% had had diabetes for two to forty years.

In addition, forty-seven percent of the patients who were studied had ischemia (reduced blood flow), and forty-four percent had neuropathy (reduced nerve function) of the foot involved.[2]

How to Decrease the Risk of an Amputation Due to Diabetes?

Steps you can take to decrease the risk of an amputation if you are diabetic [3] include:

  • Keep your blood sugars well under control to decrease the risk of peripheral neuropathy and peripheral vascular disease.
  • Check blood sugars as directed by your physician.
  • Check your feet and toes for changes in temperature or feeling every day.
  • Examine your feet daily for cracks, blisters, cuts, redness, white areas, thick calluses, and different changes in color.
  • Stop smoking.
  • Stay on a Diabetic diet.
  • Increase daily exercise levels.
  • Continue to take all prescribed medications.

HOW D’OXYVA CAN HELP?

In an ongoing multi-year, multi-country, multi-center, randomized clinical trial on patients with diabetic foot ulcers, D’OXYVA has demonstrated speeding up diabetic wound improve and ultimately wound closure to an average of 5 weeks**.

In addition, D’OXYVA eliminated pain and improved quality of life such as sleep, appetite and mood in just a week in 100% of subjects. No adverse events of any kind were reported during, and years after the studies.

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Why Good Blood Circulation Is Important for Overall Health

Proper blood circulation is the most important function of the human body, and it can play a very big role in one’s overall health. One of the vital components of the body, which is involved in this function, is the heart.

People often underestimate the important role of lifestyle choices on blood circulation, which can be significantly hindered by those choices. The following can negatively affect blood circulation:

  • Smoking
  • Not doing regular physical exercise
  • Leaving blood clots untreated
  • Having certain illnesses like heart diseases or diabetes

Patients suffering from poor blood circulation issues must consult Circularity Healthcare for advice and treatment.

The following are ways that blood circulation can impact a person’s health:

Benefits of good blood circulation

The following are a few benefits of good blood circulation:

  1. The body can maintain healthy oxygen and blood flow, which will allow the heart, lungs and muscles to function properly and efficiently.
  2. The body can avoid and fight diseases and sicknesses. In addition, white blood cells in the immune system can be transported around the body as needed.
  3. The organs will remain in proper working order and help remove waste from the body.

Risks of poor blood circulation

The following are a few effects of having poor blood circulation:

  1. One may feel a lack of energy, inability to concentrate and excessive tiredness.
  2. Limited oxygen flow to the brain can cause memory glitches.
  3. Women may suffer from hair loss or alopecia.
  4. Men may suffer from erectile dysfunction.
  5. Sores and cuts may take much longer to heal.
  6. Poor blood circulation may cause amputation of the affected limb.

 

How can one improve circulation?

To improve blood circulation, a person needs to make a few lifestyle changes. The following tips can help:

  1. Doing yoga involves the stretching and bending of the body to different postures for a certain duration. In the beginning, it may be little difficult, but soon with regular practice, one can achieve the desired results.
  2. Massages can be another great way of relaxing and unwinding. This can also help in bonding well with a partner.
  3. Engaging in certain cardiovascular exercises can help one maintain a healthy weight and can improve blood circulation.
  4. It is also important to keep the body well hydrated by drinking enough liquids, including water, to flush out all the toxins present in the blood.
  5. Many people are not aware that eating seafood can also improve blood circulation because of the omega-3 fatty acids it contains. A few of the healthiest choices are salmon, tuna, mackerel and sardines.

People suffering from poor blood circulation always risk getting blood clots and must contact a physician or healthcare professional for proper advice on improving blood circulation.

      BUY D’OXYVA

HOW D’OXYVA CAN HELP?

D’OXYVA (deoxyhemoglobin vasodilator) is the first of its kind biotech solution. D’OXYVA has been clinically validated for a variety of significant and rare health, athletic, and cosmetic benefits with record time and cost savings. The FDA-cleared medical CO2 and gentle vapor dissolves in a molecular form in the skin to improve skin perfusion pressure or blood circulation.

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Wearable technology named top health and fitness trend for 2020

health and fitness trend for 2020

More Americans are using wearable fitness trackers than ever to monitor their health, a trend the American College of Sports Medicine says is the top fitness trend for 2020, according to a recent survey.

ACSM’s “Worldwide Survey of Fitness Trends for 2020” interviewed over 3,000 health and fitness professionals, all of which said that wearable technology will be the top trend in fitness next year, with millions of Americans already using such technology to monitor their exercises, heart rate, calorie consumption, sleep quality and step count.

“Wearable tech has become ingrained in today’s culture, and the industry shows no signs of slowing down,” said Walter R. Thompson, Ph.D., ACSM Past President and lead author of the survey and associate dean in the College of Education and Human Development at Georgia State University in Atlanta. “Tech advances have made it easier than ever for users to collect important health metrics and work with fitness professionals and health care providers to improve exercise efficiency, develop healthy lifestyles, manage chronic diseases and, ultimately, increase quality of life.”

This year, ACSM published a new article alongside the survey, “Regional Comparisons: The Worldwide Survey of Fitness Trends,” which compared the top 20 fitness and health-related trends in North America, South America, Europe and China in an effort to gain a better understanding of global developments throughout different regions worldwide. The same methodology was used by ACSM’s “Worldwide Survey of Fitness Trends” in tracking these global trends.

“Through the regional comparison we hope to enhance the scope, reach and relevance of the ACSM fitness trends survey to truly make it an international collaboration,” said Vanessa M. Kercher, Ph.D., M.Ed., co-author of the regional comparison article and a clinical assistant professor in the school of public health at Indiana University. “We plan to continue developing our international partnerships with the goal of improving and expanding the implementation and methodology of the ACSM fitness trends survey. By doing so, we aim to identify fitness trends specific to different international regions so we can explore and communicate regional similarities and differences to readers.”

Wearable fitness devices are expected to evolve quite a bit in the coming years, with Apple patenting  “smart clothes” technology last year that can measure heart rate, blood sugar levels, blood pressure, electrocardiograms, blood oxygen levels and respiration rates all through sensors woven into clothing fabric.

HOW D’OXYVA CAN HELP?

Is your wearable really fitness technology or just more of a fad? If your wearable records heart rate, blood pressure, blood sugar, blood flow (perfusion index), blood oxygen (SpO2), blood pH, we challenge you to prove that you have the best wearable by testing its efficiency with D’OXYVA.

D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been clinically tested to significantly improve microcirculation.

Results of improved blood flow (perfusion index) is visible in just after 5 minutes of D’OXYVA therapy and on its highest just after 30 minutes!

Are you up for the challenge? Register below to get further details! Amazing prizes await!

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The Many Options for Non-Invasive Treatments in Pain Management You Didn’t Know

Many patients suffer from chronic pain, with little or no relief from opioids, physical therapy or even surgical treatments. For example, Ritchie was an athletic 35-year-old man who had been diagnosed with a condition called Osgood-Schlatter’s[1] Disease at the age of 15. This condition, which is a result of rapid lower extremity bone growth in adolescents, resulted in Ritchie’s suffering with bilateral knee pain and swelling below his kneecaps. At the age of 17, Ritchie underwent arthroscopic surgery on his right knee to remove damaged cartilage. Despite this treatment, he remained in chronic pain that was unrelieved by pain medication, anti-inflammatories or physical therapy. After his physician prescribed a 7-week course of daily D’OXYVA[2] treatment, Ritchie became pain free and was able to resume all of his former sports activities, including tennis and golf.

How Common is Chronic Pain?

According to the National Center for Complementary and Integrative Health[3]chronic pain (pain lasting more than 3 months) is extremely common, affecting more than 25 million American adults every day.

In addition, at least 40 million American adults suffer from non-daily but severe chronic pain.

Patients with severe chronic pain were found to generally suffer from more chronic health problems and more disability than patients with less severe pain.

What Causes Chronic Pain?

Chronic pain can result from an injury or from a disease or condition, such as one of the following:

  • Osteoarthritis
  • Rheumatoid Arthritis
  • Fibromyalgia
  • Migraine Headaches
  • Cancer
  • Diabetic Neuropathy
  • Carpal Tunnel Syndrome
  • Post-Surgical Pain

 

Non-Invasive Treatment Options for Chronic Pain

The following have been found to be useful in the treatment of chronic pain:

  • Acupuncture
  • Massage Therapy
  • Comfrey
  • Mindfulness-based Stress Reduction
  • Progressive Relaxation
  • Spinal Manipulation
  • Yoga
  • Herbal Products, such as cayenne pepper, lavender essential oil, white willow bark and devil’s claw
  • Electromagnetic Therapy
  • Biofeedback
  • Hypnotherapy
  • Meditation
  • Tai Chi

 

The Use of D’OXYVA in the Treatment of Chronic Pain

Microcirculation refers to the blood flow in the smallest blood vessels of the body, which are the venules (smallest veins) and the capillaries (connect venules and arterioles). When the microcirculation is compromised or blocked and blood flow to the nerves is reduced, chronic pain can ensue.

D’OXYVA is a commercially available non-invasive deoxyhemoglobin vasodilator that when applied to the thumb delivers a high level of pharmaceutical grade carbon dioxide (CO2) and water vapor.

The CO2 diffuses through the skin and is delivered through the blood stream, travelling to the smallest blood vessels of the body, where it has a vasodilating effect[4] and acts as a nerve stimulant that helps relieve neurogenic pain.

Diabetic patients with uncontrolled blood sugar have reported neuropathy pain relief within minutes of administration of the D’OXYVA device.

In summary, D’OXYVA is an excellent pain reliever for many different types of chronic pain.

HOW D’OXYVA CAN HELP?

D’OXYVA® (deoxyhemoglobin vasodilator) has achieved over 90%* elimination of all sorts of chronic pain in 100% of subjects either the same day or in a few days, such as from a very high 8 to a very low 1 on the Visual Analog Scale (VAS).

Pain-free life is here. Beyond major clinical outcomes for mild to extremely severe conditions, even when strong opioid-based painkillers were ineffective, new and long-term users of D’OXYVA reported relief of persistent long-term chronic pain in 2 – 7 days associated with: Neuropathy, fibromyalgia, chemo-, and radiation therapy, chronic wounds, arthritis, osteoporosis, migraine headaches, and lower back pain.

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World-Famous Institute in Miami Has Reopened as ReLife Miami Institute Under the New Leadership of Famed Neurosurgeon Dr. Gelbard, Funding Led by Circularity Healthcare

The World-famous Institute in Miami, which specialized in cosmetic and plastic surgery as well as anti-aging and wellness treatments and catered to such famous celebrities as Kim Kardashian, has reopened as ReLife Miami Institute under the new leadership of famed neurosurgeon Dr. Steven Gelbard. ReLife Miami Institute is a private Florida Domestic Profit Corporation located at 1441 Brickell Avenue, Sky Lobby Suite, within the 5-star Four Seasons Hotel in Miami, Florida.

Read article in PRWeb

LOS ANGELES, October 24, 2019

ReLife Miami Institute™, which offers the latest in stem cell therapy and regenerative medicine through its ReLife Stem Cell Institute℠ as well as neurosurgical, orthopedic and pain management services, is now under the leadership of Steven Gelbard, MD a physician licensed in the state of Florida and board certified by the American Board of Hospital Physicians.

Dr. Gelbard is a leading neurosurgeon who has been practicing medicine in South Florida for over 20 years. He specializes in treating disorders of the brain, including bleeding in the brain, head and spinal trauma, neurological tumors, spinal disorders, and infections of the brain.

“We conduct a 360-degree patient-centric evaluation and create a treatment plan with a dream team comprised of medical, nutritional, and wellness experts.” -Dr. Steven Gelbard ReLife Miami Institute, CEO

“I perform a number of procedures, including microsurgery, laser surgery, lumbar laminectomy, cervical laminectomy, evaluation and treatment of injuries to the brain and spine surgery for trauma to the brain and spine, reconstructive spinal surgery … as well as many other surgical procedures. We conduct a 360-degree patient-centric evaluation and create a treatment plan with a dream team comprised of medical, nutritional, and wellness experts.” —said Dr. Gelbard.

He received his medical degree from Tufts University School of Medicine in Boston and completed a surgical internship at New York University. Dr. Gelbard then graduated from the University of Vermont Neurosurgical Residency Program. Subsequently, he received additional training in neurosurgery and neurology at Brown University and Harvard University.

Dr. Gelbard has been granted several US patents for surgical instruments and has authored many publications in medical journals, including the Journal of Neurosurgery. Since 1991, Dr. Gelbard has operated a very successful private practice in a neurosurgery surgical center.

Circularity Healthcare, LLC, provides unique and advanced products and services for both small and large medical clinics and hospitals, helping them to structure financial transactions and obtain financing at very competitive terms in collaboration with its financing partners.

“We believe people should have access to a single medical device that solves a majority of their short- and long-term health issues quickly and without pain. D’OXYVA does that and much more when combined with stem cells and many other modalities. I am honored Dr. Gelbard’s ReLife selected our company, Circularity to manage and grow the new Miami Institute with industry-leading solutions that significantly improve chances of funding at terms that are difficult to beat by other market players.” —commented Norbert Kiss, President and CEO of Circularity.

“Circularity’s mission is giving people opportunities to interact with our brand, which definitely impacts customer acquisition rates positively. We care and that shows. As a registered nurse myself, my team’s first goal is to help patients.” —Jennifer Boadilla-Pelaez, Circularity’s Senior Sales and Marketing Manager and Creative Director supporting Relife’s marketing and public relations campaigns.

About ReLife Miami Institute

ReLife Miami Institute, LLC™ offers the latest in stem cell therapy and regenerative medicine through its ReLife Stem Cell Institute℠. It continues the long and successful history of the world-famous institute in Miami, offering plastic and reconstructive surgery, cosmetic products, IV therapy, dental surgery, sexual wellness, hair restoration, hormone replacement, anti-aging treatments and wellness counseling. ReLife Miami Institute is located inside the 5-star Four Seasons Miami hotel in Miami, Florida.

About Circularity Healthcare, LLC

Circularity Healthcare, LLC, located in Los Angeles, CA is a private biotech and medtech products and services company that designs, makes, markets, sells, distributes and licenses its own patented and patent pending technologies, such as its flagship non-invasive deoxyhemoglobin vasodilator product line, D’OXYVA®. One of the main mechanisms underlying D’OXYVA’s science received the Nobel Prize for Medicine in 2019. Circularity enters into exclusive agreements with manufacturers to launch products and with large and small clinics and hospitals in order to help them enhance their profits and credit profiles with a wide variety of advanced products and services. In addition, Circularity Healthcare assists in the financing of equipment, working capital and also patient financing at industry-leading terms and speed.

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Science underlying D’OXYVA receives the Nobel Prize in Physiology for Medicine in 2019

The Nobel Assembly at Karolinska Institutet has today decided to award the 2019 Nobel Prize in Physiology for Medicine jointly to William G. Kaelin Jr., Sir Peter J. Ratcliffe and Gregg L. Semenza for their discoveries of how cells sense and adapt to oxygen availability.

SUMMARY


Animals need oxygen for the conversion of food into useful energy. The fundamental importance of oxygen has been understood for centuries, but how cells adapt to changes in levels of oxygen has long been unknown.

William G. Kaelin Jr., Sir Peter J. Ratcliffe and Gregg L. Semenza discovered how cells can sense and adapt to changing oxygen availability. They identified molecular machinery that regulates the activity of genes in response to varying levels of oxygen.

The seminal discoveries by this year’s Nobel Laureates revealed the mechanism for one of life’s most essential adaptive processes. They established the basis for our understanding of how oxygen levels affect cellular metabolism and physiological function. Their discoveries have also paved the way for promising new strategies to fight anemia, cancer and many other diseases.

Oxygen at center stage


Oxygen, with the formula O2, makes up about one fifth of Earth’s atmosphere. Oxygen is essential for animal life: it is used by the mitochondria present in virtually all animal cells in order to convert food into useful energy. Otto Warburg, the recipient of the 1931 Nobel Prize in Physiology or Medicine, revealed that this conversion is an enzymatic process.

During evolution, mechanisms developed to ensure a sufficient supply of oxygen to tissues and cells. The carotid body, adjacent to large blood vessels on both sides of the neck, contains specialized cells that sense the blood’s oxygen levels. The 1938 Nobel Prize in Physiology or Medicine to Corneille Heymans awarded discoveries showing how blood oxygen sensing via the carotid body controls our respiratory rate by communicating directly with the brain.

 

HIF enters the scene


In addition to the carotid body-controlled rapid adaptation to low oxygen levels (hypoxia), there are other fundamental physiological adaptations. A key physiological response to hypoxia is the rise in levels of the hormone erythropoietin (EPO), which leads to increased production of red blood cells (erythropoiesis). The importance of hormonal control of erythropoiesis was already known at the beginning of the 20th century, but how this process was itself controlled by O2 remained a mystery.

Gregg Semenza studied the EPO gene and how it is regulated by varying oxygen levels. By using gene-modified mice, specific DNA segments located next to the EPO gene were shown to mediate the response to hypoxia. Sir Peter Ratcliffe also studied O2-dependent regulation of the EPO gene, and both research groups found that the oxygen sensing mechanism was present in virtually all tissues, not only in the kidney cells where EPO is normally produced. These were important findings showing that the mechanism was general and functional in many different cell types.

Semenza wished to identify the cellular components mediating this response. In cultured liver cells he discovered a protein complex that binds to the identified DNA segment in an oxygen-dependent manner. He called this complex the hypoxia-inducible factor (HIF) . Extensive efforts to purify the HIF complex began, and in 1995, Semenza was able to publish some of his key findings, including identification of the genes encoding HIF. HIF was found to consist of two different DNA-binding proteins, so called transcription factors, now named HIF-1α and ARNT. Now the researchers could begin solving the puzzle, allowing them to understand which additional components were involved and how the machinery works.

Figure 1. When oxygen levels are low (hypoxia), HIF-1α is protected from degradation and accumulates in the nucleus, where it associates with ARNT and binds to specific DNA sequences (HRE) in hypoxia-regulated genes (1). At normal oxygen levels, HIF-1α is rapidly degraded by the proteasome (2). Oxygen regulates the degradation process by the addition of hydroxyl groups (OH) to HIF-1α (3). The VHL protein can then recognize and form a complex with HIF-1α leading to its degradation in an oxygen-dependent manner (4).

​VHL: an unexpected partner


When oxygen levels are high, cells contain very little HIF-1α. However, when oxygen levels are low, the amount of HIF-1α increases so that it can bind to and thus regulate the EPO gene as well as other genes with HIF-binding DNA segments (Figure 1). Several research groups showed that HIF-1α, which is normally rapidly degraded, is protected from degradation in hypoxia. At normal oxygen levels, a cellular machine called the proteasome, recognized by the 2004 Nobel Prize in Chemistry to Aaron Ciechanover, Avram Hershko and Irwin Rose, degrades HIF-1α. Under such conditions a small peptide, ubiquitin, is added to the HIF-1α protein. Ubiquitin functions as a tag for proteins destined for degradation in the proteasome. How ubiquitin binds to HIF-1α in an oxygen-dependent manner remained a central question.

The answer came from an unexpected direction. At about the same time as Semenza and Ratcliffe were exploring the regulation of the EPO gene, cancer researcher William Kaelin, Jr. was researching an inherited syndrome, von Hippel-Lindau’s disease (VHL disease). This genetic disease leads to dramatically increased risk of certain cancers in families with inherited VHL mutations. Kaelin showed that the VHL gene encodes a protein that prevents the onset of cancer. Kaelin also showed that cancer cells lacking a functional VHL gene express abnormally high levels of hypoxia-regulated genes; but that when the VHL gene was reintroduced into cancer cells, normal levels were restored. This was an important clue showing that VHL was somehow involved in controlling responses to hypoxia. Additional clues came from several research groups showing that VHL is part of a complex that labels proteins with ubiquitin, marking them for degradation in the proteasome. Ratcliffe and his research group then made a key discovery: demonstrating that VHL can physically interact with HIF-1α and is required for its degradation at normal oxygen levels. This conclusively linked VHL to HIF-1α.

Oxygen sHIFts the balance


Many pieces had fallen into place, but what was still lacking was an understanding of how O2 levels regulate the interaction between VHL and HIF-1α. The search focused on a specific portion of the HIF-1α protein known to be important for VHL-dependent degradation, and both Kaelin and Ratcliffe suspected that the key to O2-sensing resided somewhere in this protein domain. In 2001, in two simultaneously published articles they showed that under normal oxygen levels, hydroxyl groups are added at two specific positions in HIF-1α (Figure 1). This protein modification, called prolyl hydroxylation, allows VHL to recognize and bind to HIF-1α and thus explained how normal oxygen levels control rapid HIF-1α degradation with the help of oxygen-sensitive enzymes (so-called prolyl hydroxylases). Further research by Ratcliffe and others identified the responsible prolyl hydroxylases. It was also shown that the gene activating function of HIF-1α was regulated by oxygen-dependent hydroxylation. The Nobel Laureates had now elucidated the oxygen sensing mechanism and had shown how it works.

Figure 2. The awarded mechanism for oxygen sensing has fundamental importance in physiology, for example for our metabolism, immune response and ability to adapt to exercise. Many pathological processes are also affected. Intensive efforts are ongoing to develop new drugs that can either inhibit or activate the oxygen-regulated machinery for treatment of anemia, cancer and other diseases.

Oxygen shapes physiology and pathology

Thanks to the groundbreaking work of these Nobel Laureates, we know much more about how different oxygen levels regulate fundamental physiological processes. Oxygen sensing allows cells to adapt their metabolism to low oxygen levels: for example, in our muscles during intense exercise. Other examples of adaptive processes controlled by oxygen sensing include the generation of new blood vessels and the production of red blood cells. Our immune system and many other physiological functions are also fine-tuned by the O2-sensing machinery. Oxygen sensing has even been shown to be essential during fetal development for controlling normal blood vessel formation and placenta development.

Oxygen sensing is central to a large number of diseases (Figure 2). For example, patients with chronic renal failure often suffer from severe anemia due to decreased EPO expression. EPO is produced by cells in the kidney and is essential for controlling the formation of red blood cells, as explained above. Moreover, the oxygen-regulated machinery has an important role in cancer. In tumors, the oxygen-regulated machinery is utilized to stimulate blood vessel formation and reshape metabolism for effective proliferation of cancer cells. Intense ongoing efforts in academic laboratories and pharmaceutical companies are now focused on developing drugs that can interfere with different disease states by either activating, or blocking, the oxygen-sensing machinery.

HOW D’OXYVA CAN HELP?

D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) oxygen-balanced microcirculatory solution that has been clinically tested to significantly improve microcirculation.

The improvement of oxygen-balanced microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.

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Defects in Microcirculation and the Effect on Wound Healing: New Non-Invasive Treatments

The effects of defects in and poor functioning of the microcirculation on wound healing, especially in diabetic patients, can be devastating and life changing. As one particular example, Joseph L was a 63-year-old White male with a 24-year history of diabetes mellitus, hypertension, elevated cholesterol and arthritis. Joseph had been taking insulin for the past 12 years but his blood sugar levels were still poorly controlled.

On physical exam, Joseph had several very large, oozing and foul smelling deep ulcers located on the dorsum (top) of the left foot. After 8 weeks of intensive therapy utilizing the non-invasive D’OXYVA transdermal deoxyhemoglobin vasodilator, Joseph’s ulcers healed entirely and he avoided amputation of his left foot. Read on to learn more about this new non-invasive wound treatment that helps in wound healing.

 

What is the microcirculation?

The microcirculation refers to the smallest blood vessels in the body that supply oxygen to the tissues and remove waste products. This includes the arterioles, the venules and the capillaries. When the vessels of the microcirculation become damaged, it leads to decreased blood flow with lower oxygen blood levels and resultant damage to the skin resulting in a wound or ulcer.

Risk Factors for the Creation of Chronic Wounds

Patients with the following risk factors are at greater risk for non-healing wounds or ulcers (ulcers are the most common type of chronic wounds):

  • A history of decreased blood flow to a specific area (ischemia)
  • A history of uncontrolled diabetes (which leads to poor circulation, nerve damage and breakage of the skin)
  • A history of uncontrolled hypertension (high blood pressure)
  • A history of high cholesterol and atherosclerosis (cholesterol plaques in the arteries)
  • A history of blood clots (thrombosis)

 

Diabetic Foot Ulcers

Diabetic foot ulcers are a common complication of uncontrolled diabetes mellitus.1 Chronically elevated blood sugar levels damage the microcirculation of the lower extremities, which leads to ischemia and neuropathy (damage to the nerves). Diabetic patients often lose feeling in the feet and so are not aware of friction and pressure, which leads to breaks in the skin. This subsequently leads to open wounds that often do not heal over a 30 day period. These wounds can then become infected, leading to gangrene and eventual amputation.

 

An Example of a New Non-Invasive Treatment to Enhance Wound Healing

D’OXYVA is a non-invasive transdermal deoxyhemoglobin vasodilator that delivers FDA-approved ultra-purified CO2 molecules which diffuse through the skin leading to increased skin perfusion. In studies of the treatment of diabetic foot ulcers with D’OXYVA, increased diabetic wound healing was observed with wound closure often observed within 5 weeks.

 

Conclusion

Chronic conditions like uncontrolled diabetes and hypertension can cause damage to the microcirculation, which leads to delayed wound healing. New treatment methods like D’OXYVA deliver transdermal CO2-enhanced oxygen and nutrients to wound areas through the microcirculation. This speeds up wound healing and wound closure and helps avoid devastating complications such as amputations.

HOW D’OXYVA CAN HELP?

In an ongoing multi-year, multi-country, multi-center, randomized clinical trial on patients with diabetic foot ulcers, D’OXYVA has demonstrated speeding up diabetic wound healing and ultimately wound closure to an average of 5 weeks**.

In addition, D’OXYVA eliminated pain and improved quality of life such as sleep, appetite and mood in just a week in 100% of subjects. No adverse events of any kind were reported during, and years after the studies.