Microcirculation involves the smallest branching blood vessels in the body, which are the arterioles, the venules and the capillaries. These tiny blood vessels provide essential perfusion to the tissues of the body and supply oxygen while carrying away toxic metabolic waste products. Disorders of microcirculation can affect all end organs of the body, such as through the cardiovascular system, the central nervous system, peripheral circulation to the lower extremities and blood flow to the eyes and to the kidneys. The following case study involves a patient with multiple disorders of microcirculation that were all improved by application with D’OXYVA. 
Arnie F was a 64-year-old white male with a long history of uncontrolled type 2 diabetes mellitus for the last 13 years, hypertension, depression, cardiovascular disease and kidney disease.
Due to his uncontrolled diabetes mellitus, Arnie had developed peripheral neuropathy and 2 large non healing ulcers over the malleolar areas on both feet and over the soles of both feet.
These ulcers had never completely healed over a 9-year period.
Arnie also reported severe pain in his legs and calves most nights, with a self-reported score of 7 out of a possible 10 on the visual pain scale.
On physical exam, Arnie had a blood pressure of 140/95 and a body mass index of 26.
He also had diminished pedal pulses on both feet along with 2+ edema of both lower extremities.
After application with D’OXYVA, which is a deoxyhemoglobin transdermal vasodilator, for 5 minutes twice a day for 25 days, Arnie’s previously non-healing foot ulcers were nearly completely healed and he avoided the need for amputation.
In addition, Arnie’s leg and foot pain was eliminated after 4 weeks of D’OXYVA, and his depression lifted without additional medications.
Finally, Arnie’s exertional chest pain, which was due to his cardiovascular disease, was also relieved and he was now able to walk 2 blocks without shortness of breath or chest pain.
Common Conditions Caused by Impaired Microcirculation
There are a number of common conditions caused by defects in microcirculation. These include the following:
- Non-healing diabetic foot ulcers
- Chronic pain from diabetic neuropathy
- Chronic pain from fibromyalgia
- Chronic pain from chronic wounds
- Chronic pain from degenerative arthritis
- Chronic pain from rheumatoid arthritis
- Chronic pain from osteoporosis
- Chronic pain from migraine headaches
- Chronic lower back pain
- Cardiovascular diseases such as ischemic heart disease and hypertension
- Insulin resistance
- Type 2 diabetes mellitus
- Chronic renal failure
- Peripheral vascular disease
- Venous insufficiency
Disorders of microcirculation affect many different organs and systems of the body including the cardiovascular system, the peripheral vascular system and the central nervous system. D’OXYVA has been shown to be an effective application in many conditions such as nonhealing wounds of the lower extremities and depression and in increasing strength and endurance in patients with cardiovascular diseases.
HOW D’OXYVA CAN HELP?
D’OXYVA is the only fully noninvasive, completely painless transdermal (over-the-skin) microcirculatory solution that has been validated to significantly improve microcirculation.
The improvement of microcirculation, i.e., blood flow to the smallest blood vessels, benefits one’s health, immune system and overall sense of well-being in a variety of ways.